Cryotherapy and balloon dilatation for subglottic stenosis in a neonate: a case report
Abstract
Cryotherapy and balloon dilatation are combined treatments for subglottic stenosis (SGS) in newborns. Cryotherapy involves freezing the affected area with extremely low temperatures, which can result in tissue destruction. Balloon dilatation is a technique in which a balloon is inflated in the narrow subglottic area to widen the airway. We reported a case of SGS in a neonate who was treated with a combination of cryotherapy and balloon dilatation to contribute to the growing body of evidence of the therapy and provide information for clinicians in the care of the vulnerable patients. A 22-day-old female baby, who weighed 2,600 gr at birth, was transferred to our hospital from another facility. We conducted cryotherapy on the granulation tissue area until it was released, then inflated the balloon for 5 cycles (30 sec each) with a pressure of 5-6 atm. After cryotherapy and balloon dilatation, the patient was examined using direct laryngoscopy, which revealed subglottic stenosis up to 9.5 cm from the outer border of the mouth. To maintain airway patency for the next 24 hr, the patient was intubated with an endotracheal tube number 3.5. The patient's condition improved after this intervention, and they no longer required oxygen therapy support. The patient was discharged without the need for supported oxygen. In conclusion, to manage the challenges associated with post-intubation subglottic stenosis (PI-SGS), a comprehensive approach that includes a reliable referral system, thorough bronchoscopy training, and a multi-disciplinary team is essential.
References
Gomella TL, Eyal FG, Bany-Mohammed F. MDC. Gomella’s neonatology: management, procedure, on-call problems, diseases, and drugs. 8th ed. McGraw Hill Education, 2020.
Kliegman R, Stanton B, Geme JSt, Schor N. Nelson’s textbook of paediatrics. 20th ed. Philadelphia: Elsevier, 2016.
Abdullah A, Alrabiah A, Habib SS, Aljathlany Y, Aljasser A, Bukhari M, et al. The value of spirometry in subglottic stenosis. Ear Nose Throat J 2019; 98(2):98-101.
https://doi.org/10.1177/0145561318823309
Patel KB, Prajapati O, Chauhan VM, Joshi C, Darji D. Balloon dilation laryngoplasty for acquired subglottic stenosis at a tertiary center in India. Indian J Otolaryngol Head Neck Surg 2021; 73(3):276-81.
https://doi.org/10.1007/s12070-020-02061-y
Avelino M, Maunsell R, Jubé Wastowski I. Predicting outcomes of balloon laryngoplasty in children with subglottic stenosis. Int J Pediatr Otorhinolaryngol 2015; 79(4):532-6.
https://doi.org/10.1016/j.ijporl.2015.01.022
Marston AP, White DR. Subglottic stenosis. Clin Perinatol 2018; 45(4):787-804.
https://doi.org/10.1016/j.clp.2018.07.013
Tesmer P, Wróblewska-Seniuk K, Mazela J, Szydłowski J. Congenital laryngeal stenosis and concomitant birth defects in a term newborn: a case report. Biomed Hub 2020; 5(2):453-9.
https://doi.org/10.1159/000508731
Jefferson ND, Cohen AP, Rutter MJ. Subglottic stenosis. Semin Pediatr Surg 2016; 25(3):138-43.
https://doi.org/10.1053/j.sempedsurg.2016.02.006
Cevizci R, Dilci A, Can IH, Kersin B, Bayazit Y. Flexible CO2 Laser treatment for subglottic stenosis. J Craniofac Surg 2017; 28(4):983-4.
https://doi.org/10.1097/SCS.0000000000003549
Yamamoto K, Kojima F, Tomiyama K, Nakamura T, Hayashino Y. Meta-analysis of therapeutic procedures for acquired subglottic stenosis in adults. Ann Thorac Surg 2011; 91(6):1747-53.
https://doi.org/10.1016/j.athoracsur.2011.02.071
Lawlor CM, Shah RK. A novel and promising addition to the treatment arsenal for post‐intubation subglottic stenosis: Holmium laser ablation and cryotherapy via flexible bronchoscopy. Pediatr Investig 2019; 3(1):17-8.
https://doi.org/10.1002/ped4.12114
Shadmehr MB, Abbasidezfouli A, Farzanegan R, Pejhan S, Kakhaki AD, Sheikhy K, et al. The role of systemic steroids in postintubation tracheal stenosis: a randomized clinical trial. Ann Thorac Surg 2017; 103(1):246-53.
https://doi.org/10.1016/j.athoracsur.2016.05.063
Jiao A, Liu F, Lerner AD, Rao X, Guo Y, Meng C, et al. Effective treatment of post‐intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy. Pediatr Investig 2019; 3(1):9-16.