Effects of Tricalcium Phosphate Addition as A Filler on The Properties of Chitosan Based Adhesive
Abstract
Interest in medical bioadhesives, such as wound closing and tissue repair, has increased in recent decades because of its advantages. Chitosan has been investigated in several studies and can become a bioadhesive. In this study, fillers and photoinitiators were added to the chitosan based bioadhesive, and the mechanical properties of the bioadhesive were analyzed. The fillers were added into bioadhesive at concentrations of 0.25, 0.5, and 1 %w/v. The photoinitiator was added into bioadhesive at 0, 0.05, 0.1, and 0.2%w/v concentrations. The results of SEM, FTIR, and DSC were analyzed. The analysis results show that the filler concentration of 1% w/v has mechanical properties near optimal, where the viscosity is 62.54 cP, solid content 12.1%, and tensile strength is 34 kPa. The SEM results show that adding filler will increase the homogeneity and quality of the bioadhesive. The FTIR results show that the bioadhesive has amine and alcohol groups with and without filler in the adhesive. Adding a photoinitiator to the bioadhesive, which was analyzed using DSC, showed that it would slightly speed up the adhesive reaction time and increase the material’s melting point. The increase in filler concentration will also increase the viscosity and solids content of the bioadhesive. The best adhesive combination is the TCP filler concentration 1%w/v and photoinitiator BPO 0.05%w/v. In the future, bioadhesives in medical treatment can be a potential. This research will be a benchmark for applying bioadhesives in medical treatment.
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