Profil Angular Cheilitis pada penderita HIV/AIDS di UPIPI RSUD Dr. Soetomo Surabaya 2014

https://doi.org/10.22146/majkedgiind.9032

Alexander Patera Nugraha(1*), Mintarsih Djamhari K(2), Adiastuti Endah P(3), Bagus Soebadi(4), Erwin Asta Triyono(5), Remita Adya Prasetyo(6), Sulistyowati Budi(7)

(1) Universitas Airlangga, Jawa Timur, Indonesia
(2) Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
(3) Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
(4) Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
(5) Departemen Fungsional Penyakit Dalam, Fakultas Kedokteran Universitas Airlangga, Rumah Sakit Umum Daerah Dr. Soetomo, Surabaya, Jawa Timur, Indonesia
(6) Departemen Fungsional Gigi dan Mulut Departemen Ilmu Penyakit Mulut, Rumah Sakit Umum Daerah Dr. Soetomo, Surabaya, Jawa Timur, Indonesia
(7) Departemen Fungsional Gigi dan Mulut Departemen Ilmu Penyakit Mulut, Rumah Sakit Umum Daerah Dr. Soetomo, Surabaya, Jawa Timur, Indonesia
(*) Corresponding Author

Abstract


Profile of Angular Cheilitis in HIV/AIDS Patients at UPIPI RSUD Dr. Soetomo Surabaya 2014. For over twenty years, human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) have become a significant public health concern, and the epidemic continues to challenge humanity. HIV related oral lesions can be used as markers of the immune status. Angular Cheilitis (AC) which is one of the seven oral manifestations which are strongly associated with HIV Infection, has been identified and internationally calibrated. The purpose of this research is to identify the Angular Cheilitis and its association with reduced Cluster of Differentiation 4 (CD4+) count in HIV/AIDS patients at Unit Perawatan Intermediet Penyakit Infeksi (UPIPI) RSUD Dr. Soetomo Surabaya. This was an Analytic observasional research with cross-sectional and total sampling method. The samples consisted of 88 HIV/AIDS patients treated in UPIPI RSUD Dr. Soetomo Surabaya from July to August 2014. The Diagnosis of Angular Cheilitis was based on clinical appearance; the oral cavities of the research subjects were examined by dentists specialized in Oral Medicine. CD4+ counts were obtained from the patient’s medical record. Eighty Eight HIV/AIDS patients were examined and there were 120 cases of oral manifestation. There were 31 cases of Angular Cheilitis (25,83%). Angular Cheilitis was found to be significantly correlated to the decrease in CD4+ cell count below 200 cells/mm3 (P< -,245). Risk Relative anaylsis concludes that HIV/AIDS patients with Candidiasis Oral 7.5 more often suffer from AC. There is a correlation between AC and OC (p<0,357). Angular Cheilitis may be used as an alternative to predict CD4+ count at field-based settings to diagnose the immunocompromised status of HIV-infected individuals.


Keywords


Angular Cheilitis; HIV/AIDS; CD4+

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References

Nasronudin. HIV&AIDS Pendekatan Biologi Molekuler, Klinis dan Sosial. Edisi 1. 2007. Airlangga University Press.Surabaya: Hlm.

-215.

Fanales-Belasio E, Raimondo M, Suligoi B, Butto S, HIV Virology And Pathogenetic Mechanism Of Infection: A Brief Overview. Ann

st Super Sanita. 2010. 46(1): Pp. 5-14.

Join United Nations Programme on HIV/AIDS (UNAIDS). Global Report on the Global AIDS epidemic. Journal of Epidemology. 2013 3: 5-6. From UNAIDS.org Last Update April 2014.

Kementrian Kesehatan RI. Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. Pedoman nasional Tatalaksanana Klinis Infeksi HIV dan Terapi Antiretroviral pada Orang dewasa. 2014. Jakarta: Hlm. 1-2

Unit Perawatan Intermediet Penyakit Infeksi (UPIPI). Laporan Triwulan I 2014 HIV/AIDS. 2014. RSUD Dr. Soetomo Surabaya. Hlm. 1.

Hedge M.N, Hedge N.D, Malhotra A. Prevalence of Oral Lesion in HIV Infected Adult Population of Mangalore, Karnataka-India. 2012. Reserch Article Issue. Karnataka-India 4: Pp.1.

Vaseliu N, Kamiru H, Kabue M. Oral Manifestation of HIV Infection. HIV Curriculum for the Health Professional. J Stomatology. 2011. 7(6) 53-55. Available on hivdent.org Accessed on May 2th 2014.

Patton L.L, McKaigh R, Strauss R., Rogers D, Eron JJ Jr. Changing Prevalence Of Oral Manifestations Of Human Immune-Deficiency Virus In The Era Of Protease Inhibitor Therapy. Oral Surg Oral Med Pathol Oral Radiol Endod. 2005. 89: Pp. 299-304.

Moylett EH. and Shearer W.T. HIV: Clinical manifestations. J Allergy Immunol. 2007. 110: Pp.3-16.

Greenberg MS, Glick M, Ship JA. Burkett’s Oral Medicine. 11th ed. Hamilton: BC Decker Inc; 2008. p. 81, 502.

Park KK, Brodell RT, Helms SE. Angular Cheilitis Part 1: Local Etiologies. Cutis. June 2011; 87: 289-295.

Bodhade AS, Ganvir SM, Hazarey VK. Oral manifestations of HIV infection and their correlation with CD4 count. Journal of Oral

Science, Vol. 53, No. 2, 203-211, 2011 Nagpur, Maharashtra, India. Pp. 203-211.

Davoodi P, Hamian M, Nourbaksh R, Motayamel FA. Oral Manifestations Related to CD4 Lymphocyte Count in HIV-Positive

Patients. Dental Research, Dental Clinics, Dental Prospect. Journal of Oral Med. 2014. 7(1): 3-5. Available from dentistry.tbzmed.

ac.id/joddd. Accessed on May 2th 2014.

Coogan MM, Greenspan J, Challacombe S.J. Oral Lesion in Infection with Human Immunodeficiency Virus. Bulletin of the World Organization. 2005. 83: Pp.700-706.

Park KK, Brodell RT, Helms SE. Angular Cheilitis Part 2: Nutritional, Systemic, and Drug-Related Causes and Treatment. Cutis. July 2011; 88: 27.32.

Alimonti JB, Ball TB, Fowke KR. Mechanism of CD4+ T Lymphocyte cell Death in Human Immunodeficiency Virus Infection and AIDS. Journal of General Virology. 2003. 84: Pp. 1649-1661

Sentosa E. Measurement of CD 4 By Flowcytometry in HIV Infection. Pendidikan Berkesinambungan Patologi Klinik 2005.

Departemen Patologi Klinik FK UI. Penerbit Balai UI. Jakarta: Hlm. 89-96.

Zerhouni B, Nelson J.A, Saha K. Isolation of CD4-Independent Primary Human Immunodeficiency Virus Type 1 Isolates that are Syncytium Inducing and Acutely Cytopathic for CD8+ Lymphocytes. J Virol. 2006 78(3):pp.1243-1255.

Handojo I. Imunoasai untuk penyakit infeksi virus. Imunoasai terapan pada beberapa penyakit infeksi. 2005. Airlangga University

Press. Surabaya: Hlm. 149-162.

Suripatty A, Renowati E, Triyono E.A, Purnomo W. Korelasi antara Kadar TGF-β Plasma dengan Jumlah Limfosit-T CD4+ pada

Penderita Terinfeksi HIV Stadium 1. Karya Akhir SMF Patologi Klinik, FK UNAIR, RSUD. Dr. Soetomo. Surabaya. 2014: Hlm. 50-55.

Nugraha AP, Djamhari M, Endah A, Triyono E, Prasetyo R, Budi S, Prevalensi Manifestasi Oral pada Penderita HIV AIDS di UPIPI RSUD Dr. Soetomo Surabaya 2014. Oral Medicine Dental Journal. Vol 6(1). 2004: Hlm 03.

Kartono AF, Soebadi B, Radithia D. Prevalensi Angular Cheilitis pada Waria Penderita HIV/ AIDS di PERWAKOS. Oral Medicine Dental Journal Vol. 6 No. 2 July-december 2014 ; 40-47

Peters BM, Ovchinnikova ES, Krom BP, Schlecht LM, Zhou H, Hoyer LL, Busscher HJ, Van der mei HC, Jabra-Rizk MA, Shirtliff

ME. Staphylococcus Aureus Adherence to Candida Albicans Hyphae is Mediated By The Hyphal Adhesin ALS3P. Microbiology 2012; 158: 2982-2984

Hartanto B, Hendarti HT, Soebadi B. 2011. Prevalensi Lesi Oral Yang Tekait Erat dengan HIV pada Penderita HIV/AIDS di UPIPI RSUD Dr. Soetomo Surabaya. Oral Medicine Dental Journal. 3(1): Hlm 01.

Komisi Penanggulangan AIDS Indonesia. Situasi HIV & AIDS di Indonesia. KPAI Press. 2010. Jakarta: Hlm. 2.

Nasronudin, Susilawati Y, Atika. Prevalensi Infeksi HIV/AIDS di Surabaya Indonesia. Airlangga Press. 2010 Surabaya: Hlm. 17-18.



DOI: https://doi.org/10.22146/majkedgiind.9032

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