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Studi Penggunaan Obat dan Assessment Pengobatan pada Kasus Acute Kidney Injury dan Chronic Kidney Disease di Rumah Sakit Area Makassar
https://doi.org/10.22146/farmaseutik.v21i3.106951 Andi Nur'ainun Reskia Pawallangi(1*), Wahyu Hendrarti(2), Ni Wayan Oktaviany(3), Melty Rante(4), Pinkan Fabiola Rotinsulu(5), Hasmira Hasmira(6)
(1) Departemen Farmakologi dan Farmasi Klinik, Universitas Almarisah Madani, Makassar
(2) Jurusan Farmakologi dan Farmasi Klinik, Universitas Almarisah Madani, Makassar
(3) Mahasiswa S1, Universitas Almarisah Madani, Makassar
(4) Mahasiswa S1, Universitas Almarisah Madani, Makassar
(5) Mahasiswa S1, Universitas Almarisah Madani, Makassar
(6) Mahasiswa S1, Universitas Almarisah Madani, Makassar
(*) Corresponding Author
Abstract
Acute Kidney Injury (AKI) dan Gagal ginjal akut (GGK) merupakan kondisi dengan morbiditas dan mortalitas tinggi, yang membutuhkan evaluasi terapi yang tepat akibat perubahan farmakokinetik dan farmakodinamik pada pasien. Penelitian ini bertujuan mengevaluasi penggunaan dan kesesuaian pengobatan pasien AKI dan GGK di rumah sakit wilayah Makassar, dengan desain studi observasional deskriptif retrospektif menggunakan data rekam medis Januari–Desember 2022. Sebanyak 179 pasien diteliti, terdiri dari 37 pasien GGA dan 142 pasien AKI. Terapi AKI banyak melibatkan pemberian cairan (NaCl 0,9%, Ringer Laktat), diuretik, dan nutrisi seperti Nephrosteril. Sebanyak 17 pasien AKI menunjukkan perbaikan fungsi ginjal berdasarkan kadar kreatinin dan BUN. Pada pasien GGK, 90,84% menggunakan antihipertensi, terutama golongan calcium channel blocker, loop diuretik, dan ARB. Sebanyak 66 pasien mencapai target tekanan darah (<140/90 mmHg), sementara 43 lainnya tidak tercapai, kemungkinan karena faktor usia, obesitas, konsumsi alkohol, ketidakpatuhan minum obat, dan penurunan eGFR. Secara umum, terapi sudah sesuai dengan pedoman KDIGO dan JNC 8, namun evaluasi berkala dan pendekatan individual tetap dibutuhkan untuk hasil pengobatan yang optimal.
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Chang, P.-Y., Chien, L.-N., Lin, Y.-F., Wu, M.-S., Chiu, W.-T., & Chiou, H.-Y. (2016). Risk factors of gender for renal progression in patients with early chronic kidney disease. Medicine, 95(30), e4203. https://doi.org/10.1097/MD.0000000000004203
Georgianos, P. I., & Agarwal, R. (2023). Hypertension in chronic kidney disease—Treatment standard 2023. Nephrology Dialysis Transplantation, 38(12), 2694–2703.
https://doi.org/10.1093/ndt/gfad118
Hain, D., Bednarski, D., Cahill, M., Dix, A., Foote, B., Haras, M. S., Pace, R., & Gutiérrez, O. M. (2023). Iron-Deficiency Anemia in CKD: A Narrative Review for the Kidney Care Team. Kidney Medicine, 5(8). https://doi.org/10.1016/j.xkme.2023.100677
Hustrini, N. M., Susalit, E., Lydia, A., Marbun, M. B. H., Syafiq, M., Yassir, Sarwono, J., Wardoyo, E. Y., Jonny, Suhardjono, Pradwipa, R. Y., Nugraheni, A., van Diepen, M., & Rotmans, J. I. (2023). The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta. Annals of Global Health, 89(1), 36. https://doi.org/10.5334/aogh.4071
Hustrini, N. M., Susalit, E., & Rotmans, J. I. (2022). Prevalence and risk factors for chronic kidney disease in Indonesia: An analysis of the National Basic Health Survey 2018. Journal of Global Health, 12, 04074. https://doi.org/10.7189/jogh.12.04074
Jiang, W., Shi, K., Shao, J., Song, L., Shi, Y., Wang, H., Zhou, L., Li, L., Feng, Y., Yu, J., & Zheng, R. (2025). Protective effect of intravenous amino acid on kidney function: A systematic review and meta-analysis of randomized controlled trials. Journal of Critical Care, 85, 154937. https://doi.org/10.1016/j.jcrc.2024.154937
Jonny, J., Hasyim, M., Angelia, V., Jahya, A. N., Hilman, L. P., Kusumaningrum, V. F., & Srisawat, N. (2020). Incidence of acute kidney injury and use of renal replacement therapy in intensive care unit patients in Indonesia. BMC Nephrology, 21(1), 191. https://doi.org/10.1186/s12882-020-01849-y
Kamaliah, N. I. A. (2021). Gambaran Karakteristik Pasien Gagal Ginjal Kronik Yang Menggunakan Suplemen Kalsium di Poliklinik Sub Spesialis Ginjal Hipertensi Rawat Jalan RSUD Ulin Banjarmasin. ResearchGate. https://doi.org/10.20527/jps.v8i1.8599
Katz-Greenberg, G., & Shah, S. (2022). Sex and Gender Differences in Kidney Transplantation. Seminars in nephrology, 42(2), 219–229. https://doi.org/10.1016/j.semnephrol.2022.04.011
KDIGO Clinical Practice Guideline for Acute Kidney Injury, 2012. (2012). Kidney International Supplements, 2(1), 1. https://doi.org/10.1038/kisup.2012.1
KMK No. HK.01.07-MENKES-1634-2023 ttg Pedoman Nasional Pelayanan Kedokteran Tata Laksana Ginjal Kronik-signed.pdf. (2022). Diambil 26 Februari 2025, dari https://p2ptm.kemkes.go.id/uploads/cEdQdm1WVXZuRXhad3FtVXduOW1WUT09/2024/03/KMK%20No.%20HK.01.07-MENKES-16342023%20ttg%20Pedoman%20Nasional%20Pelayanan%20Kedokteran%20Tata%20Laksana%20Ginjal%20Kronik-signed.pdf
Ku, E., Vecchio, L. D., Eckardt, K.-U., Haase, V. H., Johansen, K. L., Nangaku, M., Tangri, N., Waikar, S. S., Więcek, A., Cheung, M., Jadoul, M., Winkelmayer, W. C., Wheeler, D. C., Afsar, B., Akizawa, T., Anker, S. D., Arici, M., Babitt, J. L., Barratt, J., … Wong, M. G. (2023). Novel anemia therapies in chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney International, 104(4), 655–680. https://doi.org/10.1016/j.kint.2023.05.009
Lee, K., Ryu, D., Kim, H., Park, S., Lee, S., Park, C., Kim, G., Kim, S., & Lee, N. (2023). Selection of appropriate reference creatinine estimate for acute kidney injury diagnosis in patients with severe trauma. Acute and Critical Care, 38(1), 95–103. https://doi.org/10.4266/acc.2022.01046
Lees, J. S., & Shlipak, M. G. (2022). Age-adapted eGFR thresholds underestimate the risks beyond kidney failure associated with CKD in older populations. Journal of the American Geriatrics Society, 70(12), 3660–3664. https://doi.org/10.1111/jgs.18046
Mercado, M. G., Smith, D. K., & Guard, E. L. (2019). Acute Kidney Injury:Diagnosis and Management. Acute kidney injury, 100(11).
Kolesar, J. M., Tisdale, J. E., Ragucci, D. P., & Grady, S. E. (Eds.). (2023). Pharmacotherapy: A pathophysiologic approach (12th ed.). McGraw-Hill Education.
Katatwire, Denis., Meremo, Alfred (2023). Prevalence of and factors associated with uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania: A cross-sectional study. (2024). ResearchGate. https://doi.org/10.1136/bmjopen-2023-074441
Ravani, P., Quinn, R., Fiocco, M., Liu, P., Al-Wahsh, H., Lam, N., Hemmelgarn, B. R., Manns, B. J., James, M. T., Joanette, Y., & Tonelli, M. (2020). Association of Age With Risk of Kidney Failure in Adults With Stage IV Chronic Kidney Disease in Canada. JAMA Network Open, 3(9), e2017150. https://doi.org/10.1001/jamanetworkopen.2020.17150
Shi, Y., Duan, H., Liu, J., Shi, X., Zhang, Y., Zhang, Q., Zhao, M., & Zhang, Y. (2024). Blood urea nitrogen to serum albumin ratio is associated with all-cause mortality in patients with AKI: A cohort study. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1353956
Sukmawati, I. K., Melysa, M., Karimah, K., M, D. F. H., Widyastuti, L., Alayubi, D., & Azzahra, F. (2023). Optimalisasi peran tenaga teknis kefarmasian (ttk) dan persatuan ahli farmasi indonesia (pafi) dalam swamedikasi sediaan obat syrup diduga penyebab gangguan ginjal pada anak. Jurnal pengabdian mandiri, 2(1), Article 1. https://bajangjournal.com/index.php/JPM/article/view/4667
Survei Kesehatan Indonesia (SKI) 2023. (t.t.). Badan Kebijakan Pembangunan Kesehatan | BKPK Kemenkes. Diambil 26 Februari 2025, dari https://www.badankebijakan.kemkes.go.id/hasil-ski-2023/
Tamargo, C., Hanouneh, M., & Cervantes, C. E. (2024). Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations. Journal of Clinical Medicine, 13(9), Article 9. https://doi.org/10.3390/jcm13092455
Turgut, F., Awad, A. S., & Abdel-Rahman, E. M. (2023). Acute Kidney Injury: Medical Causes and Pathogenesis. Journal of Clinical Medicine, 12(1), 375. https://doi.org/10.3390/jcm12010375
Zaimi, M., & Grapsa, E. (2024). Current therapeutic approach of chronic kidney disease-mineral and bone disorder. Therapeutic Apheresis and Dialysis, 28(5), 671–689. https://doi.org/10.1111/1744-9987.14177
Zhao, M., Zhang, Z., Pan, Z., Ma, S., Chang, M., Fan, J., Xue, S., Wang, Y., Qu, H., & Zhang, Y. (2023). N-/T-Type vs. L-Type Calcium Channel Blocker in Treating Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Pharmaceuticals, 16(3), Article 3. https://doi.org/10.3390/ph16030338
DOI: https://doi.org/10.22146/farmaseutik.v21i3.106951
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Faculty of Pharmacy
Universitas Gadjah Mada
