Kejadian Rabbit Haemorrhagic Disease (RHD) di Peternakan Kelinci Lokal, Kabupaten Kulon Progo, Provinsi Daerah Istimewa Yogyakarta

https://doi.org/10.22146/jsv.95668

Dyah Hapsari Eka Nugraheni(1), Sri Murtini(2*), I Wayan Teguh Wibawan(3)

(1) IPB University
(2) Divisi Mikrobiologi Medik, Sekolah Kedokteran Hewan dan Biomedis, Institut Pertanian Bogor
(3) Divisi Mikrobiologi Medik, Sekolah Kedokteran Hewan dan Biomedis, Institut Pertanian Bogor
(*) Corresponding Author

Abstract


Rabbit Haemorrhagic Disease (RHD) adalah penyakit hepatitis yang fatal dan sangat menular pada kelinci domestik ataupun kelinci liar. Penyakit ini disebabkan oleh Calicivirus, genus Lagovirus, dan famili Caliciviridae. Keberadaan RHD ini telah dilaporkan sebelumnya di negara tetangga seperti Singapura pada tahun 2020. Kasus seropositif RHD pertama kali dilaporkan di Indonesia tahun 2022 pada peternakan kelinci di daerah Lembang, Bandung, Jawa Barat. Provinsi Daerah Istimewa Yogyakarta (DIY) merupakan salah satu sentra ternak kelinci terbesar ke empat di Pulau Jawa selain Jawa Tengah, Jawa Timur, dan Jawa Barat. Penelitian ini bertujuan mengetahui keberadaan RHD melalui deteksi serologi di sentra peternakan kelinci lokal di Kabupaten Kulon Progo. Sejumlah 59 ekor kelinci dari peternakan kelinci lokal di 6 kecamatan di Kabupaten Kulon Progo diperiksa keberadaan antibodi anti RHD nya. Keenam kecamatan tersebut merupakan sentra peternakan kelinci di Kabupaten Kulon Progo yaitu Kecamatan Pengasih, Nanggulan, Kalibawang, Sentolo, Panjatan, dan Girimulyo. Serum diuji menggunakan metode Indirect Enzyme-Linked Immunosorbent Assay (ELISA) untuk mengetahui titer antibodi terhadap RHD. Berdasarkan hasil pengujian ELISA diperoleh hasil 5 dari 59 sampel serum kelinci menunjukkan hasil seropositif terhadap RHD. Adanya temuan hasil seropositif RHD tersebut menjadi bukti bahwa terdapat infeksi RHD pada kelinci di peternakan kelinci lokal, Kabupaten Kulon Progo yang diindikasikan dari adanya antibodi terhadap RHD.


Keywords


kelinci; Rabbit Haemorrhagic Disease; seropositif; ELISA.

Full Text:

PDF


References

Abrantes, J., Van der Loo, W., Le Pandu, J., and Esteves, P.J. (2012). Rabbit Haemorrhagic Disease (RHD) and Rabbit Haemorrhagic Disease Virus (RHDV): A Review. Vet Res 43(1):12. doi: 10.1186/1297-9716-43-12. PMID: 22325049; PMCID: PMC3331820. Abrantes, J. and Lopes, A.M. (2021). A Review on The Methods Used for The Detection and Diagnosis of Rabbit Hemorrhagic Disease Virus (RHDV). Microorganisms. 9(5):972. doi: 10.3390/microorganisms9050972. PMID: 33946292; PMCID: PMC8146303. Badan Karantina Pertanian. (2020). Data Sistem Automatisasi Perkarantinaan IQFAST Ekspor Kelinci. Jakarta. Capucci, L., Fusi, P., Lavazza, A., Pacciarini, M.L., and Rossi, C. (1996). Detection and Preliminary Characterization of A New Rabbit Calicivirus Related to Rabbit Hemorrhagic Disease Virus but Non Pathogenic. J Virol 70:8614–8623. Cooke, B.D., Robinson, A.J., Merchant, J.C., Nardin, A., and Capucci, L. (2000). Use of ELISAs in Field Studies of Rabbit Haemorrhagic Disease (RHD) in Australia. Epidemiol Infect. 124(3):563-76. doi: 10.1017/s0950268899003994. PMID: 10982081; PMCID: PMC2810943. Cooke, B.D. (2007). A Review Of Rabbit Haemorrhagic Disease In Australia. A report Prepared for Australian Wool Innovation and Meat and Livestock Australia on The Current Status of Rabbit Hemorrhagic Disease and Its Continuing Effectiveness as a Biological Control Agent. This Literature Review Includes Recently Published and Unpublished Information from Both Australia and Overseas to Enable the Future Use of RHD to be Considered in The Widest Possible Context. Retrieved Oktober 14, 2023, from https://pestsmart.org.au/wp-content/uploads/sites/3/2020/06/Review_of_RHD_Epidemiology.pdf. Direktorat Jenderal Peternakan dan Kesehatan Hewan Kementerian Pertanian. (2022). Statistik Peternakan dan Kesehatan Hewan. Retrieved November 20, 2023, from https://satudata.pertanian.go.id/assets/docs/publikasi/Statistik_Peternakan_dan_Kesehatan_Hewan_2022_compressed.pdf. Forrester, N.L., Boag, B., Buckley., A., Moureau G., and Gould EA. (2009). Co-Circulation of Widely Disparate Strains of Rabbit Haemorrhagic Disease Virus Could Explain Localised Epidemicity in The United Kingdom. Virology. 393(1):42-8. doi: 10.1016/j.virol.2009.07.008. PMID: 19692104. Hu, B., Wei, H., Fan, Z., Song, Y., Chen, M., Qiu, R., Zhu, W., Xu, W., Xue, J., and Wang, F.(2021). Emergence of Rabbit Haemorrhagic Disease Virus 2 in China in 2020. Vet Med Sci. 7(1):236-239. doi: 10.1002/vms3.332. PMID: 32743985; PMCID: PMC7840210. Hukowska, S.B., Tokarz, D.B., and Deptuła, W. (2012). Genetic Variation and Phylogenetic Analysis of Rabbit Haemorrhagic Disease virus (RHDV) Strains. Acta Biochim Pol. 59(4):459-65. PMID: 23240105. Laurent, S., Vautherot, J.F., Madelaine, M.F., Le Gall, G., and Rasschaert, D. (1994). Recombinant Rabbit Hemorrhagic Disease Virus Capsid Protein Expressed in Baculovirus Self-Assembles into Virus Like Particles and Induces Protection. J Virol. 68(10):6794-8. doi: 10.1128/JVI.68.10.6794-6798. PMID: 8084017; PMCID: PMC237106. Le Gall, R. G., Zwingelstein, F., Fages, M.P., Bertagnoli, S., Gelfi, J., Aubineau, J., Roobrouck, A., Botti, G., Lavazza, A., and Marchandeau, S. (2011). Characterisation of A Non-Pathogenic and Non-Protective Infectious Rabbit Lagovirus Related to RHDV. Virology. 410(2):395-402. doi: 10.1016/j.virol.2010.12.001. PMID: 21195443. Le Pendu, J., Abrantes, J., Bertagnoli, S., Guitton, J.S., Le Gall-Reculé, G., Lopes, A.M., Marchandeau, S., Alda, F., Almeida, T., Célio, A.P., Bárcena, J., Burmakina, G., Blanco, E., Calvete, C., Cavadini, P., Cooke, B., Dalton, K., Delibes, Mateos, M., Deptula, W., Eden, J.S, Wang, F., Ferreira, C.C., Ferreira, P., Foronda, P., Gonçalves, D., Gavier-Widén, D., Hall, R., Hukowska-Szematowicz, B., Kerr, P., Kovaliski, J., Lavazza, A., Mahar, J., Malogolovkin, A., Marques, R.M., Marques, S., Martin-Alonso, A., Monterroso, P., Moreno, S., Mutze, G., Neimanis, A., Niedzwiedzka-Rystwej, P., Peacock, D., Parra, F., Rocchi, M., Rouco, C., Ruvoën-Clouet, N., Silva, E., Silvério, D., Strive, T., Thompson, G., Tokarz-Deptula, B., and Esteves, P. (2017). Proposal For a Unified Classification System and Nomenclature of Lagoviruses. J Gen Virol. (7):1658-1666. doi: 10.1099/jgv.0.000840. PMID: 28714849. Liu, J., Kerr, P.J., Wright, J.D., and Strive, T. (2012). Serological Assays to Discriminate Rabbit Haemorrhagic Disease Virus from Australian Non-Pathogenic Rabbit Calicivirus. Vet Microbiol. 157(3-4):345-54. doi: 10.1016/j.vetmic.2012.01.018. PMID: 22333288. Magouz, A. F., Elsayed, E.A., and Metwally, A.Y. (2019). Detection and Characterisation of Rabbit Haemorrhagic Disease Virus Strains Circulating in Egypt. Bulgarian Journal of Veterinary Medicine, 22, No 4, 409418. Marchandeau, S., Le Gall, R.G., Bertagnoli, S., Aubineau, J., Botti, G., and Lavazza, A. (2005). Serological Evidence for A Non-Protective RHDV-Like Virus. Veterinary Research, 36 (1), pp.53-62. Nagesha, H.S., Mc Coll, K.A., Collins, B.J., Morrissy, C.J., Wang, L.F., and Westbury, H.A. (2000). The Presence of Cross-Reactive Antibodies to Rabbit Haemorrhagic Disease Virus in Australian Wild Rabbits Prior to The Escape of Virus From Quarantine. Arch Virol. 145(4):749-57. doi: 10.1007/s007050050668. PMID: 10893153. Ohlinger, V.F., Haas, B., Meyers, G., Weiland, F., and Thiel, H.J. (1990). Identification and Characterization of The Virus Causing Rabbit Hemorrhagic Disease. J Virol. 64(7): 3331-6. doi: 10.1128/JVI.64.7.3331-3336.1990. PMID: 2352325; PMCID: PMC249571. Setyaningsih, R., Wibawan, I.W.T., Setiyaningsih, S., Handharyani, E., Murtini, S., and Biharidin, A. (2022). Kejadian Pertama Rabbit Haemorrhagic Disease (RHD) Berdasarkan Studi Seroprevalensi di Provinsi Jawa Barat, Indonesia. pISSN: 1411-8327; eISSN: 2477-5665. doi: 10.19087/jveteriner.2022.23.3.409. Setyaningsih R., Murtini, S., Wibawan, I.W.T., Setiyaningsih, S., and Handharyani, E. (2023). Detection of RHDV Antigen Using DAS ELISA Technique and The Influence of Breed, Sex, Age on The Incidence of RHDV Seroconversion in Asymptomatic Rabbits in West Java, Indonesia. Adv. Anim. Vet. Sci., 11(11):1897-1904. doi: https://dx.doi.org/10.17582/journal.aavs/2023/11.11.1897.1904. ISSN: 2307-8316. Soliman, M. A., Abdel Rahman, M. A. A., Samy, M.M., Mehana, O., and Nasef, S.A. (2016). Molecular, Clinical and Pathological Studies on Viral Rabbit Hemorrhagic Disease. Alexandria Journal of Veterinary Sciences, 48, 20–26. doi: 10.5455/ajvs.207505. ISSN: 1110-2047. Spickler, A.R. (2020). Rabbit Hemorrhagic Disease. Retrieved Desember 5, 2023, from https://www.cfsph.iastate.edu/Factsheets/pdfs/rabbit_hemorrhagic_disease.pdf. Strive, T., Wright, J., Kovaliski, J., Botti, G., and Capucci, L. (2010). The Non-Pathogenic Australian Lagovirus RCV-A1 Causes a Prolonged Infection and Elicits Partial Cross-Protection to Rabbit Haemorrhagic Disease Virus. Virology. 398(1):125-34. doi: 10.1016/j.virol.2009.11.045. PMID: 20034646. Sumiarto, B and Budiharta, S. (2018). Epidemiologi Veteriner Analitik. Yogyakarta: Gadjah Mada University Press. pp 61-62. World Organisation for Animal Health. (2019). Rabbit Haemorrhagic Disease. In : Aetiology Epidemiology Diagnosis Prevention and Control References. Retrieved November 5, 2023, from https://www.woah.org/fileadmin/Home/eng/Animal_Health_in_the_World/docs/pdf/Disease_cards/RHD.pdf. World Organisation for Animal Health. (2022). Chapter 13.2 Rabbit Haemorrhagic Disease (RHD) In: Terrestrial Animal Health Code. Retrieved Januari 9, 2024, from https://www.woah.org/fileadmin/Home/eng/Health_standards/tahc/current/chapitre_rabbit_haemorrhagic_disease.pdf. World Organisation for Animal Health. (2023). Chapter 3.7.2. Rabbit haemorrhagic disease. In: Terrestrial Animal Health Code. Retrieved Januari 5, 2024, from https://www.woah.org/fileadmin/Home/fr/Health_standards/tahm/3.07.02_RHD.pdf. Xu, Z.J and Chen, W.X. (1989). Viral Haemorrhagic Disease in Rabbits: A Review. Vet Res Commun. 13(3):205-12. doi: 10.1007/BF00142046. PMID: 252551093.



DOI: https://doi.org/10.22146/jsv.95668

Article Metrics

Abstract views : 230 | views : 94

Refbacks

  • There are currently no refbacks.




Copyright (c) 2024 Jurnal Sain Veteriner

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Sain Veteriner Indexed by

    CrossrefROADCOREProduct DetailsDESKRIPSI GAMBAR


Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).

Fakultas Kedokteran Hewan, Universitas Gadjah Mada

Jl. Fauna No.2, Karangmalang, Yogyakarta

Phone: 0274-560862

Fax: 0274-560861

Email: jsv_fkh@ugm.ac.id

HP. 0895363078367

Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

free
web stats View My Stats