THE EFFECT OF FEVER ON ACETYLATION RATIO AND SULFADIAZINE ELEMINATION KINETICS OF LOCAL SHEEP (Ovis aries)

https://doi.org/10.22146/jsv.8621

Ida Tjahajati(1*), Subronto Prodjoharjono(2), Budiono Santoso(3)

(1) Bagian Interna Fakultas Kedokteran Hewan UGM Yogyakarta
(2) Bagian Interna Fakultas Kedokteran Hewan UGM Yogyakarta
(3) Fakultas Kedokteran UGM Yogyakarta
(*) Corresponding Author

Abstract


A Study has been conducted to identify effect of fever towards acetylafion ratio and eleminatkm kinetics of sulfadiazine in sheep. The siudy consist 10 healthy sheep using cross­over design. Each animal was treated twice with 40 days interval. In the first treatment the sheep were given 2 gram of sulfadiazine and 0.4 gram pyrimethamine. In the second treatment the animals were treated fever induction prior to treatment using 2 gram of sulfadiazin and 0.4 gram pyrimethamine. Blood samples were taken From jugular vein in hour of 0, 0.08.0.25, 0.5, 1,2,4,6,9.12, 18, and 24. Plasma sulfadiazine levels were analyzed using Bratton-Marshall Methode. Sulfadiazin parameter was calculated using Stripe program. Theresults of the study revealed that fever did not significantly (P>0,05) increased the aceiylation ratio and inhibited elemination of sulfadiazine.


Keywords


fever, acetylation ratio, elemi nation kinetics, sulfadiazine, sheep.




DOI: https://doi.org/10.22146/jsv.8621

Article Metrics

Abstract views : 181

Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 Jurnal Sain Veteriner

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Sain Veteriner Indexed by

  CrossrefROADCOREDimensions  JournalTOCs   


Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).

Fakultas Kedokteran Hewan, Universitas Gadjah Mada

Jl. Fauna No.2, Karangmalang, Yogyakarta

Phone: 0274-560862

Fax: 0274-560861

Email: jsv_fkh@ugm.ac.id

Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

free
web stats View My Stats