Diagnosis of Feline Panleukopenia Based on Clinical Signs and Polymerase Chain Reaction in Various Ages of Cats


Mungky Ema Ramadhani(1), Soedarmanto Indarjulianto(2*), Yanuartono Yanuartono(3), Slamet Raharjo(4), Hary Purnamaningsih(5), Sitarina Widyarini(6), Yunita Apriana Milla(7)

(1) Universitas Gadjah Mada Fakultas Kedoktean Hewan
(2) Universitas Gadjah Mada
(3) Universitas Gadjah Mada Fakultas Kedoktean Hewan
(4) Universitas Gadjah Mada Fakultas Kedoktean Hewan
(5) Universitas Gadjah Mada Fakultas Kedoktean Hewan
(6) Universitas Gadjah Mada Fakultas Kedoktean Hewan
(7) Universitas Gadjah Mada Fakultas Kedoktean Hewan
(*) Corresponding Author


Feline panleukopenia (FPL) is a viral infectious disease caused by the feline panleukopenia virus (FPV) that affects cats of all ages. Clinical symptoms that appear in each individual cat vary greatly, depending on age, immune status, and the presence or absence of secondary infection. The aim of this research was to diagnose the FPL based on clinical signs and polymerase chain reaction (PCR) in cat with various ages. This study used 15 cats that showed one of clinical symptoms including lethargy, anorexia, fever, diarrhea, and vomiting. All cats were examined physically and by PCR of blood, then analyzed descriptively. The results showed that 10/15 (66.7%) cats were <7 months, 4/15 (26.7%) were 7-12 months, and 1/15 (6.6%) was >1 year old. Identification by PCR showed that 100% of the samples positive, so that all of cats diagnosed FPL. Clinical signs that commonly appeared in this study included anorexia (80%), fever (80%), vomiting (73.3%), lethargy (66.7%), and diarrhea (40%). Young cats <7 months commonly showed anorexia, fever, vomiting, and lethargy, cats aged 7-12 months commonly showed anorexia, fever, vomiting, and diarrhea, cat aged >12 months experienced anorexia and vomiting. Concluded that the predominant clinical symptoms of FPL in young cats were anorexia, fever, vomiting and lethargy, whereas in adult cats anorexia, fever, vomiting, and diarrhea. Clinical symptoms can be used for initial screening of FPL, but the causative diagnosis needs to be determined by polymerase chain reaction.


Age; clinical signs; feline panleukopenia virus; PCR

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Abd-Eldaim, M., Beall, M. J., and Kennedy, M. A. (2009). Detection of feline panleukopenia virus using a commercial ELISA for canine parvovirus. Vet Ther. 10 (4): E1-6. Arslan, M., Tezcan, E., Camci, H., dan Avci, M. K. (2021). Effect of DNA Concentration on Band Intensity and Resolution in Agarose Gel Electrophoresis. Van Sağlık Bilimleri Dergisi. 14 (3): 326-333. Awad, R. A., Khalil, W. K., dan Attallah, A. G. (2018). Epidemiology and diagnosis of feline panleukopenia virus in Egypt: Clinical and molecular diagnosis in cats. Veterinary World. 11 (5): 578. Awad, R. A., Hassan, S. A., dan Martens, B. (2019). Treatment of Feline panleukopenia virus infection in naturally infected cats and its assessment. Journal of Biological Sciences. 19 (2): 155-160. Batchelor, D. J., Devauchelle, P., Elliott, J., Elwood, C. M., Freiche, V., Gualtieri, M., Hall, E. J., Hertog, E. D., Neiger, R., Peeters, D., Roura, X., Savary-Bataille, K., dan German, A. J. (2013). Mechanisms, causes, investigation and management of vomiting disorders in cats: a literature review. Journal of feline medicine and surgery. 15 (4): 237-265. Decaro, N., Desario, C., Lucente, M. S., Amorisco, F., Campolo, M., Elia, G., Cavalli, A., Martella, V., and Buonavoglia, C. (2008). Specific identification of feline panleukopenia virus and its rapid differentiation from canine parvoviruses using minor groove binder probes. Journal of Virological Methods. 147 (1): 67-71. Graneto J. W. 2010. Pediatrics, fever medicine specialities, emergency medicine, paediatric, www.emedicine.medscape.com/specialities cit Ogoina, D. (2011). Fever, fever patterns and diseases called ‘fever’–a review. Journal of infection and public health. 4 (3): 108-124. Jacobson, L. S., Janke, K. J., Giacinti, J., dan Weese, J. S. (2021). Diagnostic testing for feline panleukopenia in a shelter setting: a prospective, observational study. Journal of Feline Medicine and Surgery, https://doi.org/10.1177/1098612X211005301. Jakel, V., Cussler, K., Hanschmann, K. M., Truyen, U., König, M., Kamphuis, E., dan Duchow, K. (2012). Vaccination against feline panleukopenia: implications from a field study in kittens. BMC Veterinary Research. 8 (1): 1-8. Kruse, B. D., Unterer, S., Horlacher, K., Sauter‐Louis, C., dan Hartmann, K. (2010). Prognostic factors in cats with feline panleukopenia. Journal of veterinary internal medicine. 24 (6): 1271-1276. Larry, P. T., dan Francis, W. K. S. (2011). Blackwell’s Five Minute Veterinary Consult Canine and Feline, 5th Edition. Willey Blackwell. pp. 475-476. Levy, J. K., Nutt, K. R., dan Tucker, S. J. (2015). Reference interval for rectal temperature in healthy confined adult cats. Journal of feline medicine and surgery. 17 (11): 950-952. Litster, A., dan Benjanirut, C. (2014). Case series of feline panleukopenia virus in an animal shelter. Journal of feline medicine and surgery. 16 (4): 346-353. Mahendra, Y. N., Yuliani, M. G. A., Widodo, A., Diyantoro, D., dan Sofyan, M. S. (2020). A Case Study of Feline Panleukopenia in Cats at The Educational Animal Hospital of Universitas Airlangga. Journal of Applied Veterinary Science And Technology. 1 (1): 6-11. Mende, K., Stuetzer, B., Truyen, U., dan Hartmann, K. (2014). Evaluation of an in-house dot enzyme-linked immunosorbent assay to detect antibodies against feline panleukopenia virus. Journal of feline medicine and surgery. 16 (10): 805-811. Miller, L., Janeczko, S., dan Hurley, K. F. (Eds.). (2021). Infectious disease management in animal shelters, 2nd edition. Ames, Iowa: Wiley-Blackwell. pp. 337-366. Mosallanejad, B., Avizeh, R., and Ghorbanpoor Najafabadi, M. (2009). Antigenic detection of Feline Panleukopenia virus (FPV) in diarrhoeic companion cats in Ahvaz area. Iranian Journal of Veterinary Research. 10 (3): 289-293. Pfankuche, V. M., Jo, W. K., van der Vries, E., Jungwirth, N., Lorenzen, S., Osterhaus, A.D.M.E., Baumgartner, W., dan Puff, C. (2017). Neuronal vacuolization in feline panleukopenia virus infection. Veterinary pathology. 55 (2): 294-297. Purnamaningsih, H., Indarjulianto, S., Yanuartono, Y., Nururrozi, A., Widiyono, I., dan Hayati, R. (2020). Gambaran Leukosit Kucing Penderita Feline Panleukopenia. Jurnal Sain Veteriner. 38 (2): 121-125. Raj, V. P., dan Haryanto, A. (2020). Clinical Study and Rapid Detection of Feline Parvovirus in Suspected Cats by Polymerase Chain Reaction Method. Indonesian Journal of Veterinary Sciences. 1 (1): 15-23. Riya, B., Rathish, R. L., Deepa, P. M., John, L., Janus, A., dan Vijaykumar, K. (2020). Clinical manifestations in cats with feline panleukopenia. Journal of Veterinary and Animal Sciences. Stuetzer, B., dan Hartmann, K. (2014). Feline parvovirus infection and associated diseases. The Veterinary Journal. 201 (2): 150-155. Sykes, J. E. (2014). Canine and feline infectious diseases. Elsevier Health Sciences. pp. 187-194. Walter-Weingärtner, J., Bergmann, M., Weber, K., Truyen, U., Muresan, C., dan Hartmann, K. (2021). Comparison of eight commercially available Faecal point-of-care tests for detection of Canine parvovirus antigen. Viruses. 13 (10): 2080. Zenad, M. M., dan Radhy, A. M. (2020). Clinical, serological and antigenic study of feline panleukopenia virus in cats in Baghdad, Iraq. Iraqi Journal of Veterinary Sciences. 34 (2): 435-439. Zhang, Q., Niu, J., Yi, S., Dong, G., Yu, D., Guo, Y., Huang, H., dan Hu, G. (2019). Development and application of a multiplex PCR method for the simultaneous detection and differentiation of feline panleukopenia virus, feline bocavirus, and feline astrovirus. Archives of virology. 164 (11): 2761-2768.

DOI: https://doi.org/10.22146/jsv.79590

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