STUDI HISTOPATOLOGIS TUMOR PADA HEWAN KESAYANGAN AND WILD ANIMAL

https://doi.org/10.22146/jsv.70506

Sitarina Widyarini(1*), Sugiyono Sultan(2), Yuli Purwandari Kristiangingrum(3), Bambang Sutrisno(4)

(1) Departemen Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada
(2) Departemen Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada
(3) Departemen Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada
(4) Departemen Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Penelitian ini dilakukan untuk mengamati gambaran histomorfologis (berdasarkan pada histogenesis dan sifat pertumbuhan tumor), pada berbagai sampel tumor dari hewan kesayangan (anjing dan kucing) dan wild animals (beruang) koleksi Departemen Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada. Duapuluh satu sampel (22) dari organ yang diduga jaringan tumor yang diperoleh dari Dokter Hewan Praktisi maupun Rumah Sakit Hewan selama tahun 2019 digunakan dalam penelitian ini. Semua sampel tersimpan dalam kontener berisi larutan formalin 10%. Selanjutnya sampel diproses dan diwarnai dengan Hematoxylin-Eosin. Pengamatan terhadap histogenesis dan sifat pertumbuhan tumor dilakulan dengan menggunakan mikroskop cahaya dengam pembesaran 200X dan 400X dan selanjutnya dilakukan dokumentasi dengan pengambilan foto. Analisis dilakukan secara deskriptif dengan membandingan dengan referensi histomofologis tumor pada hewan. Hasil penelitian memperlihatkan bahwa selama tahun 2019, jumlah sampel tumor kulit dilaporkan paling banyak  63.63% (14/22), diikuti dengan jumlah sampel tumor pada kelenjar mammae 22,72% (5/22), liver-duktus biliverus 18.18% (4/22), tulang 4,54% (1/22) dan metastasis paru-paru dan metastasis paru-paru dari jaringan tulang sejumlah 4,54% (1/22). Hewan asal tumor paling banyak ditemukan pada kucing dan anjing masing-masing 59% dan 34%. Hasil pengamatan terhadap gambaran histomorfologis ditemukan adenokarsinoma mammae (tubulopapillary carsinoma, solid adenocarsinoma, lipid-rich adenokarsinoma),  fibroadenomatous hiperplasia mammae, karsinoma sel skuamosa, papiloma, adenoma kelenjar hepatoid, melanositosis, fibrosarkoma, kolangiokarsinoma dan osteosarkoma.

 


Keywords


tumor; histomofologis; hewan kesayangan

Full Text:

PDF


References

Adiyati, S. S., dan Sosrosumiharjo, R. 2014. The Role of Various Laboratory Parameters and Imaging Associated with Obstructive Jaundice in Cholangiocarcinoma. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 15(1): 57-62. Al-Nafussi, A. 2005. Tumor Diagnosis: Practical Approach and Pattern Analysis (Edisi Kedua). New York: Oxford University Press Birbrair, A., Zhang, T., Wang, Z.-M., Messi,M. L., Olson, J. D., Mintz, A., & Delbono, O. (2014). Type-2 pericytes participate in normal and tumoral angiogenesis. American Journal of Physiology-Cell Physiology, 307(1), C25-C38. Bloom F. 1954. Pathology of the dog and cat, the genitourinary system, with clinical considerations pp. 418-424. American Veterinary Publications, Evanston, Illinois. Bonnett, B., Egenvall, A., Hedhammar, Å., & Olson, P. (2005). Mortality in over 350,000 insured Swedish dogs from 1995–2000: I. Breed-, gender-, age-and cause-specific rates. Acta veterinaria scandinavica, 46(3), 105. Brodey, R. S., M. A. Goldschmidt and J. R. Roszel, 1983. Canine mammary gland neoplasms. Journal of the American Animal Hospital Association, 19, 61−90. Browning, HM., Gulland MDF., Hammond JA., Colegrove KM., Hall AJ., (2015). Common cancer in wild animal: the California sea lion (Zalophus californianus) as an emerging model for carcinogenesis. Philosophical Transaction R. Soc. B370:20140228: 1-7 Constable, P. D., Hinchcliff, K. W., Done, S. H., & Grünberg, W. (2016). Veterinary medicine-e-book: a textbook of the diseases of cattle, horses, sheep, pigs and goats: Elsevier Health Sciences. Cronin KA. Lake AJ. Scott S. (2018), Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics. Cancer, 124: 2785-2800. doi:10.1002/cncr.31551 Cunningham, F., Fiebelkorn, S., Johnson, M., & Meredith, C. (2011). A novel application of the Margin of Exposure approach: Segregation of tobacco smoke toxicants. Food and Chemical Toxicology, 49(11), 2921-2933 Delaney, MA., Ward, JM., Walsh, TF, Chinnadurai, SK., Kerns, K., Konsel, MJ., Truting, PM., (2016). Initial case Reports of cancer in naked mole-rats (Heterocephalus glaber). Veterinary Pathology. 53: 691-696 Dietz, O., & Wiesner, E. (1982). Diseases of the horse : a handbook for science and practice Basel ; New York ; Sydney; Karger,: Fischer Elahi, R. K., Doustar, Y., dan Adalat, A. 2006. The First Case Report of Canine Cholangiocarcinoma in Iran. Diakses melalui https://www.vin.com/apputil/content/defaultadv1.aspx?pId=11223&catId=31439&id=3859170&ind=411&objTypeID=17 pada 10 September 2021 Finkelstein, JB., (2005). Sharks do get cancer: few surprises in cartilage research. Journal of National Cancer Institute. 97:1562-1563 Goldschmidt MH., Peña L., Zappulli V. (2017). Tumors of the Mammary Glands. In Tumors in Domestic Animals. 5th Edition Edited By Meuten,DJ. Pondicherry: Wiley-Blackwell. Pp 722-765. Goldschmidt MH., Goldschmidt KH. (2017). Epithelial and Melanocytic Tumors of the Skin. In Tumors in Domestic Animals. 5th Edition Edited By Meuten,DJ. Pondicherry: Wiley-Blackwell. Pp 88-141 Gupta, K., Sood, NK., Uppal, SK., Mohindroo, J., Mahajan, S., Raghunath, M., Kiranjeet Singh, K., (2012). Epidemiological Studies on Canine Mammary Tumour and its Relevance for Breast Cancer Studies. IOSR Journal of Pharmacy, 2(2):322-333 Hargis, A., Thomassen, R., Phemister, R. (1977). Chronic dermatosis and cutaneous squamous cell carcinoma in the beagle dog. Veterinary Pathology, 14(3), 218-228. Hendrick, MJ. (2017). Mesenchymal Tumors of the Skin and Soft Tissues. In Tumors in Domestic Animals. 5th Edition Edited By Meuten,DJ. Pondicherry: Wiley-Blackwell. Pp 142-176 Madsen, T., Arnal, A., Vittecoq, M., Bernex, F., Abadie, J., Labrut, S., Garcia, D., Faugere, D., Lemberger, K., Beckmann, C., Roche, B., Thomas, F., Ujvari, B., (2017). Cancer Prevalence and etiology in wild and captive animals. Ecology and Evolution of Cancer. http://dx.doi.org/10.1016/B978-0-12804310-3.00002-8 Magalhães, G. M., Silveira, A. C. T., Munari, D. P., & Alessi, A. C. (2012). Behavior of CD44 receptors in mammary tumors of dogs. Open Journal of Veterinary Medicine, 2(02), 48. Mathewos,M., Demissie,T., Fesseha, H., Yirgalem,M. (2020). Histological, Cytological Characteristics and Treatment Options on Common Skin Tumors of Domestic Animals: A Review. International Journal of Recent Biotechnology, 8(1): 1-24 McAloose, D., Newton, AL., (2009). Wildlife cancer; a conservation perspective. National Review Cancer. 9:517-526 Merlo, DF., Rossi, L., Pellegrino, C., Ceppi, M., Cardellini, U., Cappuro, C., Ratto, A., Sambucco, PL., Sestiti, V., Tanara, G., Bocchini, V., (2008). Cancer incidence in pet dogs: findings of animals tumour registry of Genia, Italy. Journal of Veterinary Internal Medicine. 22:976-984. Misdorp, W., R. W. Else, E. Hellmen and T. P. Lipscomb, 1999. Histological classification of mammary tumors of the dog and the cat. Armed Forces Institute of Pathology, American Registry of Pathology, vol. 7, Washington DC, 11–15. Moulton, J. E., 1990. Tumors in Domestic Animals, 3rd edn. University of California Press, Berkeley, 518−543; 547–552. Munson, L and Moresco, M., 2007. Comparative Pathology of Mammary Gland Cancers in Domestic and Wild Animals. Breast Disease, 28: 7-21 Naik, S., Balakrishnan, C., & Randelia, H. P. (1969). Epidemiology of horn cancer in Indian Zebu cattle: Breed incidence. British Veterinary Journal, 125(5), 222-230. Priester, W. A. (1980). The occurrence of tumors in domestic animals: US Department of Health and Human Services, Public Health Service, Proschowsky, H. F., Rugbjerg, H., & Ersbøll, A. K. (2003). Mortality of purebred and mixed-breed dogs in Denmark. Preventive veterinary medicine, 58(1- 2), 63-74. Ramadan, R. (1975). Squamous cell carcinoma of the perineum of the goat. British Veterinary Journal, 131(3), 347-350 Rezia A, Tavasoli A, Bahonar A and Mehrazma M. 2009. Grading in canine mammary gland carcinoma. Journal of Biological Sciences 9: 333-38 Rigaill, G., Parrini, M.C., Lucchesi, C. and Bellanger, D., (2010). Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO molecular medicine, 2(6), 211-230. Rutteman GR, 1990: Hormones and mammary tumour disease in the female dog: an update. In Vivo 4, 33–40. Vascellari M. Baioni E. Ru G. (2009). Animal tumour registry of two provinces in northern Italy: incidence of spontaneous tumours in dogs and cats. BMC Veterinary Research, 5:39 https://doi.org/10.1186/1746-6148-5-39 Viale, G. (2012). The current state of breast cancer classification. Annals of Oncology, 23(suppl 10), x207-x210. Villalobos, A. E. (2011). Assessment and treatment of nonpain conditions in life- limiting disease. Veterinary Clinics: Small Animal Practice, 41(3), 551-563 Vuong, D., Simpson, P. T., Green, B., Cummings, M. C., and Lakhani, S. R. (2014). Molecular classification of breast cancer. VirchowsArchiv, 465(1), 1-14.



DOI: https://doi.org/10.22146/jsv.70506

Article Metrics

Abstract views : 1169 | views : 2290

Refbacks

  • There are currently no refbacks.




Copyright (c) 2022 Jurnal Sain Veteriner

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Sain Veteriner Indexed by

    CrossrefROADCOREDimensions  JournalTOCs   


Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).

Fakultas Kedokteran Hewan, Universitas Gadjah Mada

Jl. Fauna No.2, Karangmalang, Yogyakarta

Phone: 0274-560862

Fax: 0274-560861

Email: jsv_fkh@ugm.ac.id

Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

free
web stats View My Stats