Efficacy of Albendazole Against Strongylus sp. and Hematology Changes on Equine in Yogyakarta Special Region

https://doi.org/10.22146/jsv.60110

yuriadi yuriadi(1*), Ida Tjahajati(2), Guntari Titik Mulyani(3), Kelviano Muqit(4), Aidah Rahmanita(5)

(1) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada
(2) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada
(3) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada
(4) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(5) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(*) Corresponding Author

Abstract


The infestation of Strongylus sp. in horses can cause losses to horse breeders, including anorexia, anemia, gastrointestinal diseases and can cause death and decrease the horse population in DIY. Albendazole was a Benzimidazole preparation that is often used to treat worms in ruminants. This study also aims to determine the effect of Albendazole on blood images before and after treatment. The material used in this study were 10 horses with male and female sex,  over 3 years old, and infected with Strongylus sp. with an infestation rate of 200 EPG in faeces. Before treatment of drug was carried out, the faeces was examined with Mc Master method. After treatment with Albendazole, the worm eggs were examined three times at intervals of three days. Routine examination of worm eggs and blood was carried out at the Laboratory of the Department of Internal Medicine, Faculty of Veterinary Medicine, Universitas Gadjah Mada. The results showed that the EPG number decreased from the 0th, 3rd, 6th and 9th day of examinations. The average number of EPG on the 0th day was 990 eggs/gram, and the examination on the 9th day showed the number of eggs was 0 eggs/gram. The results of the hematology examination also showed no significant difference except for the high number of eosinophils on the 12th day after drug administration. The conclusion from this research is that Albendazole as a worm medicine can kill Srongylus sp. however, it does not affect the horse's hematology and health status.


Keywords


Horse; Strongylus sp.; Albendazole; hematology status; EPG

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References

Agina, O.A. (2017). Haematology and clinical biochemistry findings associated with equine diseases: A Review. Not.SCI. Biol 9(1) : 1-21. Amin, M.R., Mostofa, M., Awal, M.A., dan Sharmin, M.L. (2008). Comparative efficacy of Barbados lilac, pineapple, and Benazol® against gastrointestinal nematodes in cattle. Progress. Agric. 19(1) : 51-59. Amirullah, Dradjat, A.S, Sriasih, M., Maskur, Depamede, S.N., Kisworo, D., dan Kurniasih. (2018). Pengaruh Fasciolosis pada Sapi Bali Berdasarkan Pemeriksaan Darah, Serum Glutamic Pyruvic Transaminase (SGPT) dan Alkaline Phosphatase (ALP). JSV 36(2) : 247-253. Apriliawati, E., Mufasirin, Wurlina, Hastutiek, P., Suwanti, L.T., Tehupuring, B.C. (2019). Prevalensi dan Tingkat Infeksi Nematoda pada Saluran Gastrointestinal Kuda (Equus caballus) di Bangkalan Madura. Journal of Parasite Science 3(2) : 83-88. Axon, J.E and Palmert, J.E. (2008). Clinical pathology of the Foal. Vet Clin Equine 24 : 357 -385. Barrelet, A and Rickets, S. (2013). Haematology and blood biochemistry in the horse : a guide to interpretation. Retrieved September 20, 2020, from https ://inpractice.bmj.com. Cernea, L.C., Cernea, M., Ognean, L., Nastasa, V., Raileanu, S., Mares, M., Chereji, A. and Carvalho, L.M. (2007). The efficacy of tetrahydropyrimidines and benzimidazoles combination in equine Strongylidosis. Rev. Sc. Parasitol., Vol. 3 (1) : 28-35. Demeler J, Van Zeveren, A.M, Kleinschmidt, N, Vercruysse J, Höglund J, Koopmann R, Cabaret J, Claerebout E, Areskog M dan von Samson- Himmelstjerna G. (2009). Monitoring the efficacy of ivermectin and Albendazole against gastrointestinal nematodes of cattle in Northern Europe. Veterinary Parasitology 160(1) : 109-15. Gokbulut, C., F. Akar, Q. A. dan McKellar. (2005): Plasma disposition and fecal excretion of oxfendazole, fenbendazole and Albendazole following oral administration to donkeys. Vet. J. 172, 166-172. Guzel, S., Tanriverdi, M., dan senlik, B. (2014). Selected biochemical parameters in Strongyle infections of horses and its relationship with the parasite burden. Bulgarian Journal of Agricultural Science, 20 (5) :1233-1236. Egbu, M.I. Florence., O.P. Ubachukwu, C.I. Okoye. (2013). Haematological Changes Due to Bovine Fascioliasis. Afr. J. Biotechnol., 12 (15):1828-1835. Hastutiek, P., Sasmita, R. and Mahasri, G. (2001). Prevalensi Infeksi Cacing Saluran Pencernaan pada Sapi, Kerbau dan Kuda di Kabupaten Bangkalan, Madura. Media Kedokteran Hewan 17 (1) : 67-72. Islam, M., Islam, S., Holader, M, R. dan Lucky, N.S. (2015). Comparative efficacy of Albendazole, Fenbendazole and Levamisole against gastrointestinal nematodiasis in cattle of Bangladesh. International Journal of Biological Research 3(1) : 23-35. Imam, S.M.A., Seri, H.I., Hassan, T., Tigani, T.A., Zolain, H.B. and Abakar, A.D. (2010). Therapeutic efficacy evaluation of anthelmintic activity of Albendazole and ivermectin drench formulations in donkeys in Darfur, Sudan. Vet.Archive 80 (5): 585-595. Khalid, S. M. A., Amin, M. R., Mostofa, M., Choudhury, M. E. and Uddin, B. (2005). Effects of indigenous medicinal plants (neem and pineapple) against gastrointestinal nematodiasis in sheep. Internat. J. Pharma., 1(2): 185-189. Koesdarto, S., S. Subekti., S.M. Sosiawati., H. Puspitawati dan Kusnoto. (2007). Buku Ajar Ilmu Penyakit Nematoda Veteriner. Departemen Pendidikan Nasional Fakultas Kedokteran Hewan Universitas Airlangga. Surabaya. Hal: 1‐5 Kristiyani, F., Aini, N., dan Wiyanati, A.D. (2019). Evaluasi pengobatan Trematodiasis menggunakan Albendazol pada sapi di Kecamatan Pakem, Sleman, Daerah Istimewa Yogyakarta. JSV. 37(1) : 104-111. Kuzmina, T. A., dan Kharcenko, V.O (2008): Anthelmintic resistance in cyathostomins of brood horses in Ukraine and influence of anthelmintic treatments on Strongylid community structure. Vet. Parasitol. 154, 277-288. Louise, L.S. (2013). Practical Guide to Equine Colic. 1th ed. John Willey & Sons, Inc Published, Iowa. Love, S. 2003. Treatment and prevention of intestinal parasite associated disease. Vet. Clin. Equine. 19: 791 ‐ 806. Matthews, J.B. (2014). Anthelmintic resistance in equine nematodes. Vet. Parasitol 4 : 310-315. Nofyan, E., M. Kamal dan I. Rosdiana. (2010). Identitas jenis telur cacing parasit usus pada ternak sapi (Bos sp.) dan kerbau (Bubalus sp.) di rumah potong hewan Palembang. Jurnal Penelitian Sains. (D) 10:06-11. Peregrine, A.S., Molento, M.B., Kaplan, R.M., Nielsen, M.K.. (2014). Anthelmintic resistance in important parasites of horses: does it really matter?. Vet. Parasitol. 201, 1–8. Plumb, D. (2011). Albendazole. Plumb's Veterinary Drug Handbook. 7th ed. Wisconsin; Ames, Iowa. Willey. 19-21 Pradana, F.H.A. 2012. Tingkat Kejadian Helminthiasis Gastrointestinal pada Kuda Pacu di PT. KTS Pohsarang, Kediri. [Tesis] Fakultas Kedokteran Hewan, Universitas Airlangga. Surabaya. Ratnawati, E.W. 2004. Kejadian Infeksi Cacing Parasit Saluran Pencernaan pada Kuda Delman di Kota Bogor. [Skripsi] Fakultas Kedokteran Hewan Institut Pertanian Bogor: Bogor. Rob, S., Mostofa, M., Awal, M. A., Shahiduzzaman, M. and Sardar, S. A. (2014). Comparative efficacy of Albendazole (Endokil®) and neem (Azadirachta indica) leaves extract against haemonchosis in sheep. Prog. Agril., 15(2): 33-39. Saeed, K., Qadir, Z., Khan, S.A., Ashraf, K. dan Nazir, S. (2008). Evaluation of some broad spectrum antiparasitic drugs against natural Strongyl infections in horses. J. Anim. Pl. Sci. 18(2-3): 64-66. Salas-Romero, J., Gomez-Cabrera, K.A., Salas, J.E., Vazquez, R., Arenal, A., dan Nielsen, M.K. (2018). First report of anthelmintic resistance of equine cyathostomins in Cuba. Veterinary Parasitology: Regional Studies and Reports 13 :220–223 Siregar, D.O. 2016. Prevalensi Cacing Nematoda dan Derajat Infeksi Nematodiasis Kuda di Kota Batu. [Tesis] Fakultas Kedokteran Hewan, Universitas Airlangga. Surabaya. Soutello RG, Seno, M.C dan Amarante, A.F. (2009) Anthelmintic resistance in cattle nematodes in northwestern São Paulo State, Brazil. Veterinary Parasitology 148(3-4), 360-364. Subekti, S., S. Mumpuni, S. Soedarto, H. Puspitawati dan Kusnoto. (2010). Buku Ajar Parasitologi Veteriner. Fakultas Kedokteran Hewan Universitas Airlangga. Surabaya. Wiedosari. E., H. Hayakawa, B. Copeman. 2006. Host differences in response to trickle infection with Fasciola gigantica in buffalo, Ongole and Bali calves. Trop. Anim. Health Prod. 38:43-53. Yuriadi. (2007). Data Hematologi Kuda yang dipelihara Di Daerah DIY dan Jawa Tengah. Seminar Nasional dan Kongres PDHI, Jakarta. Zhang,W.Y., M. Moreau,B.Z. Yang, Z. Q.Li, J.C. C. Hope, J. Howard, Y. W.Huang. (2006). Humoral And Cellular Immune Responses To Fasciola Gigantica Experimental Infection In Buffaloes. Research In Vet. Sc. 80: 299-307.



DOI: https://doi.org/10.22146/jsv.60110

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