Fucoidan : Manfaat dalam Industri Peternakan


Yanuartono Yanuartono(1), Alfarisa Nururrozi(2*), Hary Purnamaningsih(3), Soedarmanto Indarjulianto(4), Slamet Raharjo(5)

(1) Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(2) Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(3) Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(4) Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(5) Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author


Research of interest marine algae and seagrasses have been renewed, because they are considered to be promising resources of functional ingredients in the development of novel products. Fucoidans are a class of fucose-rich sulfated carbohydrates found in brown marine algae and echinoderms, and more recently identified in seagrasses. Chemical compositions of most fucoidans are complex, mainly being composed of fucose and sulfate. They also contain other monosaccharides like mannose, galactose, glucose, xylose and uronic acids, even acetyl groups and protein and it’s have potential therapeutic properties, including anti-viral activity. Currently, fucoidans are available for use in therapeutic and dietary supplements for inclusion in pet, livestock and aquaculture feed supplements. This review summarizes experimental evidence indicating that Fucoidan can improve the quality of feed ingredients for livestock, pets and aquaculture to improve health.


Seagrasses; Fucoidan; Therapeutic properties; Dietary supplements

Full Text:



Abdoun, K.A., Okab, A.B., El-Waziry, A.M., Samara, E.M. and Al-Haidary, A.A. (2014) Dietary supplementation of seaweed (Ulva lactuca) to alleviate the impact of heat stress in growing lambs. Pak Vet J., 34 (1): 108-111.

Agatonovic-Kustrin, S. and Morton, D.W. (2013) Cosmeceuticals Derived from Bioactive Substances Found in Marine Algae. Oceanography 1(1): 1-15.

Ale, M.T. and Meyer, A.S. (2013) Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation. RSC Adv., 3 (22): 8131–8141.

Ale, M.T., Mikkelsen, J.D. and Meyer, A.S. (2011) Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds. Mar. Drugs, 9 (10): 2106-2130.

Ale, M.T., Mikkelsen, J.D. and Meyer A.S. (2012) Designed optimization of a single-step extraction of fucose-containing sulfated polysaccharides from Sargassum sp. J. Appl. Phycol. 24 (4):715–723.

Alekseyenko, T. V., Ya Zhanayeva, S., Venediktova, A. A., Zvyagintseva,T. N., Kuznetsova, T. A., Besednova, N. N. and Korolenko, T. A. (2007) Antitumor and Antimetastatic Activity of Fucoidan, a Sulfated Polysaccharide Isolated From the Okhotsk Sea Fucus Evanescens Brown Alga. Bull Exp Biol Med 143 (6): 730-732.

Al-Mabruk, R.M. (2013) Nutritional Part of Sheep and Goat in Libya. Int J Adv Biol Biom Res. 1(2) : 112-133.

Anastyuk, S. D., Shevchenko, N. M., Nazarenko, E. L., Dmitrenok, P. S. and Zvyagintseva, T. N. (2009) Structural analysis of a fucoidan from the brown alga Fucus evanescens by MALDI-TOF and tandem ESI mass spectrometry. Carbohydr. Res. 344 (6) : 779–787.

Atashrazm, F., Lowenthal, R.M., Woods, G.M., Holloway, A.F. and Dickinson, J.L. (2015) Review Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential. Mar. Drugs 13 (4): 2327-2346.

Bendary, M.M., Bassiouni, M.I., Ali, M.F., Gaafar, H.M. and Shamas, A.S. (2013) Effect of premix and seaweed additives on productive performance of lactating Friesian cows. Academia Journal of Agricultural Research 1(4): 052-059.

Berteau, O. and Mulloy, B.( 2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology, 13(6):29R-40R.

Briseño, J.A.A., Suarez, L.C.E., Sassi, J.F., Marie, D.R., Benavides, P.Z., Gamboa, E.M., Padilla, C.R., and Avila, L.M.T. (2015) Sulphated Polysaccharides from Ulva clathrata and Cladosiphon okamuranus Seaweeds both Inhibit Viral Attachment/Entry and Cell-Cell Fusion, in NDV Infection. Mar. Drugs 13(2): 697-712.

Bonos, E., Kargopoulos, A., Nikolakakis, I., Florou-Paneri, P. and Christaki, E. (2016) The Seaweed Ascophyllum nodosum as a Potential Functional Ingredient in Chicken Nutrition. J Oceanogr Mar Res. 4 (1) : 2-5.

Burtin, P. (2003) Nutritional value of seaweeds. Electronic Journal of Environmental, Agricultural and Food Chemistry 2(4) :498-503.

Caipang,,C.M., Lazado, C.C., Berg, I., Brinchmann, M.F. and Kiron, V. (2011) Influence of alginic acid and fucoidan on the immune responses of head kidney leukocytes in cod. Fish Physiol Biochem 37 (3): 603-612.

Chale-Dzul, J., Moo-Puc, R., Robledo, D. and Freile-Pelegrín, Y. (2014) Hepatoprotective effect of the fucoidan from the brown seaweed Turbinaria tricostata. 5th Congress Of The International Society For Applied Phycology. J Appl Phycol. :1-13.

Chaubet, F., Chevolot, L., Jozefonvicz, J., Durand, P. and Boisson-Vidal, C. (2000) Relationships between chemical characteristics and anticoagulant activity of low molecular weight fucans from marine algae. In Bioactive Carbohydrate Polymers; Paulsen, B.S., Ed.; Springer: Heidelberg, Germany. 44: 59–84.

Chen, Y.M., Tsai, Y.H., Tsai, T.Y., Chiu, Y.S., Li Wei, L., Chen, W.C. and Chi-Chang Huang, C.C. (2015) Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice. Nutrients 7 (1): 239-252.

Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. and Colliec- Jouault, S. (2001) A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae. Carbohydrate Research, 330 (4): 529–535.

Choi, J.I., Raghavendran, H.R., Sung, N.Y., Kim, J.H.and Chun, B.S. (2010) Effect of fucoidan on aspirin-induced stomach ulceration in rats. Chem Biol Interact 183 (1): 249-254

Choi, Y.J., Hosseindoust, A., Goel, A., Lee, S., Jha, P.K., Kwon, I.K. and Chae, B.J. (2017) Effects of Ecklonia cava as fucoidan-rich algae on growth performance, nutrient digestibility, intestinal morphology and caecal microflora in weanling pigs. Asian-Australas J Anim Sci. 30(1): 64–70.

Choi, Y. J., Lee, S. R. and. Oh, J.W. (2014) Effects of Dietary Fermented Seaweed and Seaweed Fusiforme on Growth Performance, Carcass Parameters and Immunoglobulin Concentration in Broiler Chicks. Asian-Australas. J. Anim. Sci. 27 (6): 862-870.

Chotigeat, W., Tongsupa, S., Supamataya, K. and Phongdara, A. (2004) Effect of fucoidan on disease resistance of black tiger shrimp. Aquaculture, 233 (1-4): 23-30.

Chung, H.J., Jeun, J., Houng, S.J., Jun, H.J. and Kweon, D.K. (2010) Toxicological evaluation of fucoidan from Undaria pinnatifidain vitro and in vivo. Phytother Res 24(7): 1078-1083.

Cvetkovic, B., Brouk, M. J. and Shirley, J. E. (2004) Impact Of Dried Seaweed Meal On Heat-Stressed Lactating Dairy Cattle. Dairy Day. Kansas State University, Manhattan, KS, 2004 : 59-61

Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G.E., Berman, A.E., Bilan, M.I., Usov, A.I., Ustyuzhanina, N.E., Grachev, A.A., Sanderson, C.J., Kelly, M., Rabinovich, G.A., Iacobelli, S. and Nifantiev, N.E. (2007) A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology, 17 (5): 541–552.

Cunha, L. and Grenha, A. (2016) Review Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery ApplicationsMar. Drugs 14 (3): 1-42.

Cuong, H.D., Thuy, T.T., Huong, T.T., Ly, B.M. and Van, T.T. (2015) Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum. Nat Prod Res. 29 (5):411–415.

Dalmo, R.A. and Seljelid, R. (1995) The immunomodulatory effect of LPS, laminaran and sulphated laminaran [β (l,3)-D-glucan] on Atlantic salmon, Salmo salar L., macrophages in -vitro. Journal of Fish Diseases, 18 (2): 175-185.

Dillon, S., Sweeney, T., Callan, J.J. and O’ Doherty, J.V. (2009) The effects of lactose inclusion and seaweed extract on performance, nutrient digestibility and microbial populations in newly weaned piglets. 11th International Symposium on Digestive Physiology of Pigs, Hotel Termes de Montbrio´, Montbrio´ del Camp, Costa Daurada, Spain, 20–22 May 2009, abstract 5.30 :151.

El-Waziry, A., Al-Haidary, A., Okab, A., Samara, E. and Abdoun, K. (2015) Effect of dietary seaweed (Ulva lactuca) supplementation on growth performance of sheep and on in vitro gas production kinetics. Turk J Vet Anim Sci 39: 81-86.

Fitton, J.H. (2011) Therapies from fucoidan; multifunctional marine polymers. Marine drugs 9 (10): 1731–1760.

Fitton, J.H., Stringer, D.N. and Karpiniec, S.S. (2015) Review Therapies from Fucoidan: An Update. Mar. Drugs, 13 (9): 5920-5946.

Gahan, D.A., Lynch, M.B., Callan, J.J., Julka, A. and O’Doherty, J.V. (2009) Performance of weanling piglets offered low, medium or high lactose diets supplemented with a seaweed extract from Laminaria Hyperborea. Animal 3 (1): 24–31.

Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P. And Ray, B. (2009) Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation. Glycobiology, 19 (1):2–15.

Gideon, T.P. and Rengasamy, R. (2008) Toxicological Evaluation of Fucoidan from Cladosiphon okamuranus. J Med Food 11 (4) : 638–642.

Gojon-Baez, H.H., Siqueiros-Beltrones, D.A. and Hernandez-Contreras, H. (1998) In situ ruminal digestibility and degradability of Macrocystis pyrifera and Sargassum spp. in bovine livestock. Cienc. Mar. 24 (4): 463-481.

Gonzalez,R.E., Suarez, E.C. L, Marie, D.R., Gamboa, E.M., Padilla C.R. and Avila, L.M.T. (2012) In vitro characterization of the antiviral activity of fucoidan from Cladosiphon okamuranus against Newcastle Disease Virus. Virology Journal. 9 (1):307-315.

Hahn, T., Lang, S., Ulber, R. and Muffler, K. (2012) Muffler Novel procedures for the extraction of fucoidan from brown algae Process Biochem, 47 (12): 1691–1698.

Heim, G., Sweeney, T., O'Shea, C.J., Doyle, D.N. and O'Doherty, J.V. (2014) Effect of maternal supplementation with seaweed extracts on growth performance and aspects of gastrointestinal health of newly weaned piglets after challenge with enterotoxigenic Escherichia coli K88. Br J Nutr 112 (12) : 1955–1965.

Hidari, K.I., Takahashi, N., Arihara, M., Nagaoka, M., Morita, K. and Suzuki, T. (2008) Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga. Biochem Biophys Res Commun., 376 (1): 91–95.

Hong, Z. S., Kim, E. J., Jin, Y. C., Lee, J. S., Choi, Y. J. and Lee, H. G. (2015) Effects of Supplementing Brown Seaweed By-products in the Diet of Holstein Cows during Transition on Ruminal Fermentation, Growth Performance and Endocrine Responses. Asian Australas. J. Anim. Sci. 28 (9) : 1296-1302.

Hurst, D. (2006) Marine functional foods and functional ingredients. Oranmore, Galway, Ireland: A briefing document. Marine Institute. 1-72.

Ilias, N. N., Jamal, P., Jaswir, I., Sulaiman,. S., Zainudin, Z. and Azmi, A. S. (2015) Potentiality Of Selected Seaweed For The Production Of Nutritious Fish Feed Using Solid State Fermentation. Journal of Engineering Science and Technology. Special Issue on SOMCHE 2014 & RSCE 2014 Conference, January : 30 – 40.

Immanuel, G., Sivagnanavelmurugan, M., Marudhupandi, T., Radhakrishnan, S. And Palavesam, A. (2012) The effect of fucoidan from brown seaweed Sargassum wightii on WSSV resistance and immune activity in shrimp Penaeus monodon (Fab). Fish Shellfish Immunol., 32(4): 551-564.

Islam, M. M., Ahmed, S. T., Kim, Y. J., Mun, H. S., Kim, Y. J. and Yang, C. J. (2014) Effect of sea tangle (Laminaria japonica) and charcoal supplementation as alternatives to antibiotics on growth performance and meat quality of ducks. Asian-Australas J Anim Sci 27 (2) :217-24.

Isnansetyo, A., Fikriyah, A., Kasanah, N. and Murwantoko. (2016) Non-specific immune potentiating activity of fucoidan from a tropical brown algae (Phaeophyceae), Sargassum cristaefolium in tilapia (Oreochromis niloticus). Aquaculture International. 24 (2): 465-477.

Jeong, B.E., Ko, E.J. and Joo, H.G. (2012) Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouraciltreated dendritic cells. Food Chem Toxicol, 50 (5): 1480-1484.

Jiao, G., Yu, G., Zhang, J. and Ewart, H.S. (2011) Chemical structures and bioactivities of sulfated polysaccharides from marine algae. Mar Drugs, 9(2):196–223.

Jimenez-Escrig, A., Gomez-Ordonez, E. and Ruperez. P. (2011) Seaweed as a source of novel nutraceuticals: Sulfated polysaccharides and peptides. Adv. Food Nutr. Res. 64:325- 337.

Jin, J.O., Zhang,W., Du, J.Y., Wong, K.W., Oda, T. and Yu, Q. (2014) Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses. PLoS One. 9(6): 1-10.

Kadzere, C.T., Murphy, M.R., Silanikove, N.and Maltz, E. (2002) Heat stress in lactating dairy cows:A review. Livest. Prod. Sci. 77:59-91.

Khotimchenko, S.V., Vaskovsky V.E. and Titlyanova, T.V. (2002) Fatty acids of marine algae from the Pacific coast of north California. Botanica Marina, 45 (1): 17-22.

Kim, K.W., Kim, S.S., Khosravi, S., Rahimnejad, S. and Lee, K.J. (2014) Evaluation of Sargassum fusiforme and Ecklonia cava as Dietary Additivesfor Olive Flounder (Paralichthys olivaceus). Turk. J. Fish. Aquat. Sci. 14(2): 321-330.

Kumar, V. and Kaladharan, P. (2007) Amino acids in the seaweeds as an alternate source of protein for animal feed. source of protein for animal feed J. Mar. Biol. Ass. India, 49 (1) : 35 – 40.

Kylin, H. (1913) Biochemistry of sea algae. H. Z. Physiol. Chem. 83:171-197.

Li, D.Y., Xu, Z., Huang, L.M., Wang, H.B. and Zhang, S.H. (2001) Effect of fucoidan of L. japonica on rats with hyperlipidaemia. Food Sci. 22: 92–95.

Lynch, M. B., Sweeney, T., Callan, J. J., O’Sullivan, J. T. and O’Doherty. J. V. (2010) The effect of dietary Laminaria-derived laminarin and fucoidan on nutrient digestibility, nitrogen utilisation, intestinal microflora and volatile fatty acid concentration in pigs. J. Sci. Food Agric. 90 (3):430–437.

Makkar, H.P.S., Tran, G., Heuzé, V., Reverdin, S.G., Michel Lessire, M., François Lebas, F. and Ankers. P. (2015) Seaweeds in livestock diets : a review. Animal Feed Science and Technology. 1-25.

Marudhupandi, T. and Kumar, T.T.A. (2013a) Antibacterial effect of fucoidan from Sargassum wightii against the chosen human bacterial pathogens. International Current Pharmaceutical Journal, 2(10): 156-158.

Marudhupandi, T. and Kumar T.T.A. (2013b) Effect of fucoidan from Turbinaria ornata against marine ornamental fish pathogens. Journal of Coastal Life Medicine 1(4): 282-286.

Mauray, S., Sternberg, C., Theveniaux, J., Millet, J., Sinquin, C., Tapon- Bretaudière, J. and Fischer, A. (1995) Venous antithrombotic and anticoagulant activities of a fucoidan fraction. Thromb Haemost., 74:1280–1285.

McAlpine, P., O’Shea, C.J., Varley, P.F., Flynn, B. and O’Doherty, J.V. (2012) The effect of seaweed extract as an alternative to zinc oxide diets on growth performance, nutrient digestibility, and fecal score of weaned piglets. J Anim Sci 90 Suppl 4: 224-226.

McDonnell, P., Figat, S. and O’Doherty, J. V. (2010) The effect of dietary laminarin and fucoidan in the diet of the weanling piglet on performance, selected faecal microbial populations and volatile fatty acid concentrations Animal 4 (4) :579–585.

Moghadamtousi, S.Z., Karimian, H., Khanabdali, R., Razavi, M., Firoozinia, M., Zandi, K. and Kadir H.A. (2014) Review Article Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae Scientific World Journal. 2014 (2014): 1-10.

Norziah, M.H. and Ching, C.Y. (2000) Nutritional composition of edible seaweed Gracilaria changgi - an edible species of nori from Nova Scotia. Food Chemistry, 68 (1): 69-76.

Novak, M. And Vetvicka, V. (2008) Beta-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol. 5(1):47-57.

O’Doherty, J.V., McDonnell, P. And Figat, S. (2010) The effect of dietary laminarin and fucoidan in the diet of the weanling piglet on performance and selected faecal microbial populations. Liv Sci 134 (1-3): 208–210.

O’Shea, C. J., O’Doherty, J. V., Callanan, J. J., Doyle, D., Thornton, K. and Sweeney T. (2016) The effect of algal polysaccharides laminarin and fucoidan on colonic pathology, cytokine gene expression and Enterobacteriaceae in a dextran sodium sulfate-challenged porcine model. Journal of Nutritional Science, 5 (e15) : 1-9.

Painter, T.J. (1983) Algal polysaccharides. In: Aspinall GO (ed) The polysaccharides, Vol. 2. Academic, New York, :195–285.

Park, S. B., Chun, K. R., Kim, J. K., Suk, K., Jung, Y.M. and Lee, W. H. (2010) The differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice. Phytother. Res. PTR, 24 (9): 1384–1391.

Pompeu, L. B., Williams, J. E., Spiers, D. E., Weaber, R. L., Ellersieck, M. R., Sargent, K. M., Feyerabend, N. P., Vellios, H. L. and Evans, F. (2011) Effect of Ascophyllum nodosum on alleviation of heat stress in dairy cows. The Professional Animal Scientist 27 (3) :181–189.

Pulz, O. and Gross, W. (2004) Valuable products from biotechnology of microalgae. Appl. Microbiol. Biotechnol., 65 (6): 635-648.

Raghavendran, H.R.B., Srinivasan, P. and Rekha, S. (2011) Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats. International Immunopharmacology 11(2): 157–163.

Sanjeewa, K.K., Fernando, I.P., Kim, E.A., Ahn, G., Jee, Y. and Jeon, Y.J. (2017) Anti-inflammatory activity of a sulfated polysaccharide isolated from an enzymatic digest of brown seaweed (Sargassum horneri) in RAW 264.7 cells. Nutr Res Pract.11(1):3-10.

Serrano Jr., A.E. and Aquino, J.I.L. (2014) Protein concentrate of Ulva intestinalis (Chlorophyta, Ulvaceae) could replace soybean meal in the diet of Oreochromis niloticus fry. AACL Bioflux, 7 (4) : 255-262.

Skriptsova, A.V., Shevchenko, N. M., Zvyagintseva, T.N. and Imbs, T. I. (2009) Monthly changes in the content and monosaccharide composition of fucoidan from Undaria pinnatifida (Laminariales, Phaeophyta). Journal of Applied Phycology, 22(1): 79-86.

Sweeney, T., Dillon, S., Fanning, J., Ega, J., O'Shea, C.J., Figat, S., Gutierrez, J.J.M., Mannion, C., Leonard, F. And O’Doherty,J.V. (2011) Evaluation of seaweedderived polysaccharides on indices of gastrointestinal fermentation and selected populations of microbiota in newly weaned pigs challenged with Salmonella Typhimurium. Anim. Feed Sci. Technol., 165 (1-2): 85-94.

Takahashi, Y., Uehara, K., Watanabe, R., Okumura, T., Yamashita, T., Omura, H., Yomo, T., Kawano, T., Kanemitsu, A., Narasaka, H., Suzuki, N. and Itami, T. (1998) Efficacy of Oral Administration of Fucoidan, a Sulfated Polysaccharide, in Controlling White Spot Syndrome in Kuruma Shrimp in Japan. Advances in Shrimp Biotechnology Proceedings to the special session on shrimp biotechnology 5th Asian Fisheries Forum, 11-14 November 1998 Chiangmai, Thailand.

Taylor, P., Nishino, T., Aizu, Y. and Nagumo, T. (1991) The relationship between the molecular weight and the anticoagulant activity of two types of fucan sulfates from the brown seaweed Ecklonia kurome. Agric. Biol. Chem., 55 (3): 791–796.

Tayyab, U., Novoa-Garrido, M., Roleda, M.Y., Lind, V. and Weisbjerg, M.R. (2016) Ruminal and intestinal protein degradability of various seaweed species measured in situ in dairy cows. Animal Feed Science and Technology 213: 44–54.

Traifalgar, R.F., Kira, H., Tung, H.T., Michael, F.R., Yokoyama, A.L.S., Ishikaw, M.A. and Koshio, S. (2010) Influence of dietary fucoidan supplementation on growth and immunological response of juvenile Marsupenaeus japonicus. Journal of the World Aquaculture Society 41(2): 235–244.

Trejo-Avila, L.M., Morales-Martínez, M.E., Ricque-Marie, D., Cruz-Suarez, L.E., Zapata-Benavides, P., Morán-Santibañez, K. and Rodríguez-Padilla, C. (2014) In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus. Virusdisease. 25 (4): 474-80.

Tuller, J., De Santis, C. and Jerry, D.R. (2012) Dietary influence of Fucoidan supplementation on growth of Lates calcarifer (Bloch). Aquaculture Research, 45 (4) : 749-754

Tzovenis, I., De Pauw, N. and Sorgeloos, P. (2003) Optimisation of T-Iso biomass production rich in essential fatty acids. 1. Effect of different regimes on growth and biomass production. Aquaculture, 216 (s1-4): 203-222.

Ventura, M.R., Castañon, J.I.R. and McNab J.M. (1994) Nutritional value of seaweed (Ulva rigida) for poultry. Animal Feed Science and Technology 49 (1-2): 87–92.

Walsh, A.M., Sweeney, T., O’Shea, C.J., Doyle, D.N. and O’Doherty, J.V. (2013) Effect of dietary laminarin and fucoidan on selected microbiota, intestinal morphology and immune status of the newly weaned pig. Br J Nutr 110 (9): 1630-1638.

Wang, W., Wu, J., Zhang, X., Hao, C., Zhao, X., Jiao, G., Shan, X., Tai, W. and Yu, G. (2017) Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway. Scientific Reports 7, Article number: 40760.

Wijesinghe, W.A.J.P., Athukorala, Y. and Jeon, Y.J. (2011) Effect of anticoagulative sulfated polysaccharide purified from enzyme-assistant extract of a brown seaweed Ecklonia cava on Wistar rats. Carbohydr. Polym. 86 (2): 917–921.

Yang, J.W., Yoon, S.Y., Oh, S.J., Kim, S.K. and Kang, K.W. (2006) Bifunctional effects of fucoidan on the expression of inducible nitric oxide synthase. Biochem Biophys Res Commun, 346 (1): 345-350.

Yang, M., Ma, C., Sun, J., Shao, Q., Gao, W., Zhang, Y., Li, Z., Xie, Q., Dong, Z. And Qu, X. (2008) Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells. Int Immunopharmacol, 8 (13-14): 1754-1760.

Yang, J.H. (2012) Topical application of fucoidan improves atopic dermatitis symptoms in NC/Nga mice. Phytother. Res., 26 (12) : 1898-1903.

Yanuartono, Indarjulianto, S., Nururrozi, A., Purnamaningsih, H., Raharjo, S., Widiyono, I., Yuriadi, Wuryastuti, H., Hartati, S., Tjahajati, I., dan Mulyani, G.T. (2017) Pengaruh pemberian ekstrak rumput laut coklat terhadap gambaran darah ayam broiler.Hibah Penelitian PPDH, FKH-UGM

DOI: https://doi.org/10.22146/jsv.33507

Article Metrics

Abstract views : 2618 | views : 1296


  • There are currently no refbacks.

Copyright (c) 2018 Jurnal Sain Veteriner

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Sain Veteriner Indexed by


Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).

Fakultas Kedokteran Hewan, Universitas Gadjah Mada

Jl. Fauna No.2, Karangmalang, Yogyakarta

Phone: 0274-560862

Fax: 0274-560861

Email: jsv_fkh@ugm.ac.id

HP. 0895363078367

Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


web stats View My Stats