Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE

Shelly Kusumarini(1*), Lita Rakhma Yustinasari(2), Eka Pramystha Hestianah(3), Suryo Kuncorojati(4), Tutik Juniastuti(5)

(1) Universitas Airlangga
(2) Universitas Airlangga
(3) Universitas Airlangga
(4) Universitas Airlangga
(5) Universitas Airlangga
(*) Corresponding Author


The aim of this research was to explore the influence of Mozart KV 448 classical music therapy to the neuroglia cells of mice’s hippocampus that were exposed to stress during prenatal. This research were employing twenty female mices and twenty male mices. Female mices were estrus synchronized with PMSG and hCG then monomating to the males. Pregnant females were then divided into four groups (P0, P1, P2, P3). P0 was as control, P1 was treated by one minute forced swim test, P2 was treated by one minute forced swim test followed by thirty
minutes classical music Mozart KV 448 and P3 was treated by one minute forced swim test followed by sixty minutes classical music Mozart KV 448. This research was carried out for twenty-one days during gestation period. The neuroglia density result was analyzed using ANOVA and Duncan test. The neuroglia activity result was
analyzed using Kruskal wallis test and Z test. The histology reading showed degradation of density and activity of hippocampus neuroglia.


prenatal stress, classical music; Mozart KV 448; neuroglia; hippocampus

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Airan, R. D., Meltzer, L. A., Roy, M., Gong. Y., Chen,

H, Deisseroth, K. (2007). High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science Magazine. 3 (17): 819-823.

Allen, N. J., and Barres, B. A. (2005). Signaling between glia and neurons: focus on synaptic plasticity. Curr Opion. Neurobiol. 15 (5): 542-548.

Amagdei, A., Baltes, F.R., Avram, J., Miu A.C. (2010). Perinatal exposure to music protects spatial memory against callosal lesions. Int J Dev Neurosci. 28(1): 105-109.

Atkinson, H.C., Waddell, B.J. (1995). The hypothalamic-pituitary-adrenal-axis in rat pregnancy and lactation: circadian variation and interrelationship of plasma adrenocorticotropin and corticosterone.

Endocrinology 136: 512-520.

Barros, V.G., Duhalde-Vega, M., Caltana, L., Brusco, A., Antonelli, M.C. (2006). Astrocyte-neuron vulnerability to prenatal stress in adult rat brain. J Neurosci 83: 787-800.

Bennett, H. A., Taddio, A., Koren, G., Einarson, T.R. (2004a). Depression during pregnancy: overview of clinical factors. Clin Drug

Investig. 24: 157-179.

Bennett, H.A., Einarson, A..,Taddio, A., Koren, G., Einarson, T.R. (2004b). Prevalence of depression during pregnancy: systematic

review. Obstet Gynecol. 103:698–709.

Bilmes, J. (2005). Anatomy and physiology of the ear. Departement of electrical engineering. University of Washington.

Brown, S. (2004). Passive music listening spontaneously engages limbic and paralimbic systems. NeuroReport. 15: 2033–2037.

Huerta, F Jauregui., Delgadillo, Y Ruvalcaba., Gonzalez-Castañeda., Garcia-Estrada J., Perez, O. Gonzalez, and Luquin, S. (2010). Responses of glial cells to stress and glucocorticoids. Curr Immunol. 6(3): 195–204.

Jauˇsovec, N., Jauˇsovec, K., & Gerlic, I. (2006). The influence of Mozart’s music on brain activity in the process of learning. Clinical

Neurophysiology. 117: 2703–2714.

Kim, H., Lee M.H, Chang H.K, Lee T.H, Lee H.H,Shin M.C, et al,. (2006). Influence of prenatal 8

Shelly Kusumarini R et al. noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats. Brain Dev. 28 (2): 109-114.

Kusumarini, Shelly. R., Tutik Juniastuti, Lita Yustinasari. (2016). Musik klasik mozart KV 448 menyebabkan penurunan abnormalitas

neuroglia hipokampus mencit (Mus musculus) yang mengalami stres prenatal. Vet Med. 9 (1):49-54.

Lazarus, R. S., Delongis, A., Folkmann, S., Gruen, R. (1985). Stress and adaption outcomes (The problem of confound measures). American Phycologist. 40(7): 770-790.

Lipton, S. A., Rosenberg, P.A. (1994). Excitatory amino acids as a final common pathway for neurologic disorders, N. Engl. J. Med. 3 (30): 613–622.

Matthies, U., Balog J, Lehmann K. (2013). Temporally coherent visual stimuli boost ocular dominance plasticity. J Neurosci; 33 (29): 11774-11778.

Mustofa, Tika Rhmatillah. (2013). Skrripsi. Pengaruh musik terhadap proliferasi neuron hipokampus mencit (Mus musculus) yang mengalami stres. Universitas Airlangga.

Oberlander, T.F., Warburton, W., Misri, S., Aghajanian, J. Hertzman, C. (2006). Neonatal outcomes after prenatal exposure to selective

serotonin reuptake inhibitor antidepressants and maternal depression using populationbased linked health data. Arch Gen Psychiatry. 63:898–906.

Rodriguez, A. Bohlin, G. (2005). Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?. J Child

Psychol Psychiatry. 46: 246–254.

Rodriguez, F., Lopeza JC., Vargasa JP., Broglioa C., Gomeza Y., Salas C. (2002). Spatial memory and hippocampal pallium through vertebrate evolution: insights from reptiles and teleost

fish. Brain Res. Bull. 57 (3-4): 499–503. PMID 11923018.

Srivastava, D.P., Woolfrey KM, Penzes P. (2013). Insights into rapid modulation of neuroplasticity by brain estrogens. Pharmacol

Rev. 65 (4): 1318-1350.

Tiina-Riikka M. Pirttila, Asla Pitkanen, Jarkko Tuunanen, and Risto A. Kauppinen. (2001). Ex vivo mr microimaging of neuronal damage

after kainate-induced status epilepticus in rat: correlation with quantitative histology. Magnetic Resonance in Medicine. 46: 946–

Tollenaar, M.S., Beijers R, Jansen J, Riksen-Walraven JM, de Weerth C. (2011). Maternal prenatal stress and cortisol reactivity to stressors in human infants stress. Stress. 14 (1): 53–65.

Vina, Y. (2012). Skripsi. Pengaruh terapi musik terhadap stres pada Mus musculus dengan induksi food shock. Under graduate Airlangga

University. KKB KK-2 FF 357/ 11 Yuw p.

Weissman, C. (1990). The metabolic response to stress:an overview and update. Anaesthesiology. 73:308–27.

Wise, R.A. (2004). Dopamine, learning and motivation. Nat. Rev. Neurosci. 5: 483–494.


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