EKSPRESI MMP-9 DAN TIMP-1 PADA AMELOBLASTOMA TIPE FOLIKULAR, PLEKSIFORM DAN AKANTOMATOSA

Abstract

Ameloblastoma is a common odontogenic tumor located in jaws, and is considered as a benign but agressive and locally invasive, which is difficult to treat and cause morbidity. Many histolopathological variant of ameloblastoma. Pleksiform type, folikular type and acanthomatous type are the most common, and each has potensial to become more agressive than others. Matrix metalloproteinase-9 (MMP-9) and Tissue inhibitor of metalloproteinase-1 (TIMP-1) are proteinases that participate in extracellular matrix(ECM) degradation, influencing the aggresivity. The aim of study is to make an observation of the balance between MMP-9 and TIMP-1(MMP-9 inhibitor)in three different histopathological type of ameloblastoma. All the subject are derrived from laboratorium of pathology Dr. Sardjito Hospital, in form of parafin block of ameloblastoma, from oral surgery’s patients, Dr. Sardjito Hospital,
Yogyakarta, in year 2008-2012. Three main histopathological type will be the subjects, each subjects will be stained by HE, MMP-9 and TIMP-1, and the immunoscore will be taken to compare the expressions that describe the agressivity. Both protein MMP-9 and TIMP-1 were detected in all 28 (77,8%) subjects of ameloblastoma ; 10 (35,7%) subjects each for pleksiform type and  follicular type;
8 (28,6%) subjects for acanthomatous type. In the comparation of expression MMP-9/TIMP-1. There were a significant difference between group of follicular type and acanthomatous type (p:0,025). there were no significant difference between group of  follicular type  and plexiform type (p:0,185) and so between plexiform type and acanthomatous type (p:0,314).