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Determination Of Paracetamol, Guaiphenesin, Chlorpheniramine Maleate And Phenylpropanolamine Hydrochloride In Cough And Cold Tablet Using High Performance Liquid Chromatography


 
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1. Title Title of document Determination Of Paracetamol, Guaiphenesin, Chlorpheniramine Maleate And Phenylpropanolamine Hydrochloride In Cough And Cold Tablet Using High Performance Liquid Chromatography
 
2. Creator Author's name, affiliation, country Yani Abdul Ardiyanti; The the National Agency of Drug and Food Control, district of Palangkaraya, Central Kalimantan, Indonesia; Indonesia
 
3. Subject Discipline(s)
 
3. Subject Keyword(s)
 
4. Description Abstract

The method of choice for analysis of drugs in multi-component preparations is chromatographic based technique such as high performance liquid chromatography (HPLC). A liquid chromatographic method was applied for the analysis paracetamol (PCT), guaiphenesin (GG), chlorpheniramine maleate (CTM) and phenylpropanolamine HCl (PPA) using three different system as described in the USP XXXVI/NF 31. The method depends on a separation on  reversed-phase C8, C18 and Phenyl column for analysis PCT, GG, and CTM-PPA respectively with mobile phase water-methanol-acetic acid glacial (79:20:1) for PCT, water-methanol-acetic acid glacial (60:40:1,5) for GG and methanol-water (60:40) containing 0.34 g of monobasic potassium phosphate, 0.05 g of triethylamine hydrochloride, 0.25 g of sodium lauryl sulfate, and 0.1 mL of phosphoric acid in each 100 mL for CTM-PPA. Quantitation was achieved with UV detection at 280, 276 and 214 nm respectively for PCT, GG, and CTM-PPA based on peak area. The methods were validated in terms of system suitability test, specificity, precision, accuracy, linearity, and the results were found to be satisfactory.

 

Keywords: RP-HPLC, Paracetamol, Guaiphenesin, Chlorpheniramine maleate, Phenylpropanolamine HCl.
 
5. Publisher Organizing agency, location Fakultas Farmasi, Universitas Gadjah Mada
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2014-06-16
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF (PP. 83-92)
 
10. Identifier Uniform Resource Identifier https://jurnal.ugm.ac.id/jfps/article/view/5370
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.14499/jfps
 
11. Source Title; vol., no. (year) Journal of Food and Pharmaceutical Sciences; Vol 2, No 3 (2014): J. Food Pharm. Sci (Sept-December)
 
12. Language English=en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c)