Correlation between Triglyceride/HDL Ratio with Severity of Coronary Artery Lesion in Non-Diabetic Stable Angina Pectoris Patients
Pramon Aditya Sudjana(1*), Chaerul Achmad(2), Achmad Fauzi Yahya(3), Januar W. Martha(4), M. Rizki Akbar(5)
(1) Department of Cardiology and Vascular Medicine, Hasan Sadikin Hospital, Bandung.
(2) Department of Cardiology and Vascular Medicine, Hasan Sadikin Hospital, Bandung.
(3) Department of Cardiology and Vascular Medicine, Hasan Sadikin Hospital, Bandung.
(4) Department of Cardiology and Vascular Medicine, Hasan Sadikin Hospital, Bandung.
(5) Department of Cardiology and Vascular Medicine, Hasan Sadikin Hospital, Bandung.
(*) Corresponding Author
Abstract
Background: Triglycerides (TG) as a risk factor for coronary artery disease (CAD) is still a matter of controversy but when used as a single ratio with high density lipoprotein (HDL) the predictive value for CAD is better. The TG/HDL ratio is also associated with the presence of small dense LDL (sdLDL) in the body. SdLDL is a more atherogenic LDL subfraction and has been proven to be associated with CAD progression.
Aims: This study aims to find the correlation between the TG/HDL ratio and the degree of coronary lesion severity based on the Gensini score in stable non diabetic angina pectoris patients.
Methods: This study was a cross sectional study conducted at Dr. Hasan Sadikin Hospital and Hasna Medika Palimanan Hospital. Subjects were non diabetic stable angina pectoris patients ≥18 years old who underwent elective coronary angiography. Blood collection for TG and HDL examination was performed after coronary angiography. Gensini scoring system was used to assess the severity of coronary lesions. The relationship between the TG/HDL ratio and the Gensini score was analyzed using multiple linear regression tests against confounding variables.
Results: This study involved 60 patients with stable angina pectoris with a mean age of 60±8 years. The mean TG/HDL ratio is 2.56 ± 1.04. The average Gensini score was 51 ± 36. The TG/HDL ratio was significantly associated with the Gensini score (R = 0.637; p <0.001). Analysis of confounding variables showed age, hypertension, and metabolic syndrome had a weak correlation with Gensini score (r values of 0.321, 0.270, and 0.333, p <0.05, respectively), while those correlating with TG/HDL ratios were men, hypertension, and metabolic syndrome (r values of 0.290, 0.287, and 0.362, p <0.05, respectively).
Conclusion: TG/HDL ratio was significantly positively correlated significantly with the severity of coronary lesions based on Gensini score in non diabetic stable angina pectoris patients.
Keywords
Full Text:
PDFReferences
Aboyans V., Ricco J.B., Bartelink M.E.L., Bjorck M., Brodmann M., et al. 2018 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the
European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg, 55(3):305-368.
Gibbons R.J., Abrams J., Chatterjee K., Daley J., Deedwania P.C., Douglas J.S., et al. 2003. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina-- summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina). J Am Coll Cardiol, 41(1):159-168.
Okrainec K., Banerjee D.K., Eisenberg M.J. 2004. Coronary artery disease in the developing world. Am Heart J, 148(1):7-15.
Ostfeld R., Mookherjee D., Spinelli M., Holtzman D., Shoyeb A., Schaefer M., et al. 2006. A triglyceride/high-density lipoprotein ratio > or = 3.5 is associated with an increased burden of coronary artery disease on cardiac catheterization. J Cardiometab Syndr,
(1):13-15.
Conkbayir C., Ayca B., Okcun E.B. 2015. Lipid variables related to the extent and severity of coronary artery disease in non-diabetic Turkish Cypriots. Iran J Public Health, 44(9):1196-1203.
Luz P.Ld., Favarato D., Junior J.R.FN., Lemos P., Chagas A.C.P. 2008. High ratio of triglycerides to HDLcholesterol predicts extensive coronary disease. clinics, 63:427-432.
Hadaegh F., Khalili D., Ghasemi A., Tohidi M., Sheikholeslami F., Azizi F. 2009. Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men. Nutr Metab Cardiovasc Dis, 19(6):401-408.
Yang D., Liu X., Xiang M. 2011. The correlation between lipids ratio and degree of coronary artery stenosis. High Blood Press Cardiovasc Prev, 18:53-56.
Barzi F., Patel A., Woodward M., Lawes C.M., Ohkubo T., Gu D., et al. 2005. A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region. Ann Epidemiol, 15(5):405-413.
Hanak V., Munoz J., Teague J., Stanley A.Jr., Bittner V. 2004. Accuracy of the triglyceride to high density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B. Am J Cardiol, 94(2):219-222.
Dobiasova M., Frohlich J. 2001. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoproteindepleted plasma (FER(HDL)). Clin Biochem, 34(7):583-538.
Giorgis T.D., Mohn A. 2014. Could the triglyceride:HDL cholesterol ratio be considered a new marker of cardiovascular risk in obese children? Clin Lipidol, 9(1):1-3.
Maruyama C., Imamura K., Teramoto T. 2003. Assessment of LDL particle size by triglyceride/HDL-cholesterol ratio in non-diabetic, healthy subjects without prominent hyperlipidemia. J Atheroscler Thromb, 10(3):186-191.
Nordestgaard B.G., Varbo A. 2014. Triglycerides and cardiovascular disease. Lancet, 384(9943):626-35.
Tornvall P., Karpe F., Carlson L.A., Hamsten A. 1991. Relationships of low density lipoprotein subfractions to angiographically defined coronary artery disease in young survivors of myocardial infarction. Atherosclerosis, 90(1):67-80.
Stampfer M.J., Krauss R.M., Ma J., Blanche P.J., Holl L.G., Sacks F.M., et al. 1996. A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA, 276(11):882-888.
Gardner C.D., Fortmann S.P., Krauss R.M. 1996. Association of small lowdensity lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA, 276(11):875- 881.
Moon J.Y., Kwon H.M., Kwon S.W., Yoon S.J., Kim J.S., Lee S.J., et al. 2007. Lipoprotein(a) and LDL particle size are related to the severity of coronary artery disease. Cardiology, 108(4):282-289.
Kwon S.W., Yoon S.J., Kang T.S., Kwon H.M., Kim J.H., Rhee J., et al. 2006. Significance of small dense low density lipoprotein as a risk factor for coronary artery disease and acute coronary syndrome. Yonsei Med J, 47(3):405-414.
DOI: https://doi.org/10.22146/aci.40854
Article Metrics
Abstract views : 3740 | views : 3129Refbacks
- There are currently no refbacks.
Copyright (c) 2018 Pramon Aditya Sudjana, Chaerul Achmad, Achmad Fauzi Yahya, Januar W. Martha, M. Rizki Akbar
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
ACI (Acta Cardiologia Indonesiana) is indexed by:
ACI (Acta Cardiologia Indonesiana) is published by:
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Address: Radiopoetro Building 2nd Floor, West Wing, Farmako Street, Sekip, Yogyakarta, Indonesia 55281
ACI (Acta Cardiologia Indonesiana) is endorsed by: