Dynamic Changes of Sp6 Transgene Expression in Dental Epithelial Cells during Long-term Culture
Trianna W. Utami(1*), Keiko Miyoshi(2), Hiroko Hagita(3), Ryna D. Yanuaryska(4), Taigo Horiguchi(5), Takafumi Noma(6)
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(*) Corresponding Author
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Thesleff I. 2003. Epithelial-mesenchymal signal- ling regulating tooth morphogenesis. J Cell Sci,116:1647-1648.
Brook AH. 2009. Multilevel complex interaction between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Arch Oral Biol, 54 Suppl 1:S3- S17.
Thesleff I. 2006. The genetic basis of tooth de- velopment and dental defects. Am J Med Genet A, 140:2530-2535
Jimenez-Rojo L, Ibarretxe G, Aurrekoetxea M, de Vega S, Nakamura T, Yamada Y, and Unda F. 2010. Epiprofin/Sp6: a new player in the regula- tion of tooth development. Histol Histopathol, 25:1621-1630.
Suske G, Bruford E, and Philipsen S. 2005. Mam- malian SP/KLF transcription factors: Bring in the family. Genomics, 85:551-556.
Scohy S, Gabant P, Van Reeth T, Herveldt V, Dr- eze PL, Van Vooren P, Riviere M, and Szpirer C. 2000. Identification of KLF13 and KLF14 (Sp6), novel members of the Sp6/XKLF transcription factor family. Genomics, 70:93-101.
Nakamura T, Unda F, de-Vega S, Vilaxa A, Fuku- moto S, Yamada KM, and Yamada Y. 2004. The Kruppel-like factor epiprofin is expressed by ep- ithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. J Biol Chem, 279:626-634.
Bei M. 2009. Molecular genetics of ameloblast cell lineage. J Exp Zool B Mol Dev Evol, 312B:437-444.
Nakamura T, de Vega S, Fukumoto S, Jimenez L, Unda F, and Yamada T. 2007. Transcription fac- tor epiprofin is essential for tooth morphogen- esis by regulating epithelial cell fate and tooth number. J Biol Chem, 283:4825-4833.
Hertveldt V, Lourya S, Van Reeth T, Drèze P, Van Vooren P, Szpirer J, and Szpirer C. 2008. TThhee ddee- velopment of several organs and appendages is impaired in mice lacking Sp6. Dev Dyn, 237:883-892.
Ruspita I, Miyoshi K, Muto T, Abe K, Horiguchi T, and Noma T. 2008. Sp6 down regulation of follistatin gene expression in ameloblast. J Med Invest, 55:87-98
Wahyudi IA, Horiguchi T, Miyoshi K, Muto T, Utami TW, Hagita H, and Noma T. 2010. IIssoollaa- tion and characterization of mouse specificity protein 6 promoter. Indones J Den Res, 1:21-34.
Miyoshi K, Nagata H, Horiguchi T, Abe K, Wahyu- di IA, Baba Y, Harada H, and Noma T. 2008. BMP2-induced gene profiling in dental epithe- lial cell line. J Med Invest, 55:216-226
Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T, and Noma T. 2011. Possible linkage of SP6 transcriptional activity with amelogene- sis by protein stabilization. J BiomedBiotechnol, doi:10.1155/2011/320987.
Zhu WG, Dai Z, Ding H, Srinivasan K, Hall J, Duan W, Villalona-Calero MA, Plass C, and Otterson GA. 2001. Increased expression of unmethylat- ed CDKN2D by 5-aza-2'-deoxycytidine in human lung cancer cells. Oncogene, 20:7787-7796.
Marks PA and Xu WS. 2009. Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Bio- chem, 107:600-608.
Abe K, Miyoshi K, Muto T, Ruspita I, Horiguchi T, Nagata T, and Noma T. 2007. Establishment and characterization of rat dental epithelial de- rived ameloblast-lineage clones. J Biosci Bioeng.103:479-485.
Grassi G, Maccaroni P, Meyer R, Kaiser H, Am- brosio ED, Pascale E, Grassi M, Kuhn A, Nardo PDi, Kandolf R, and Kupper JH. 2003. Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. Carcinogenesis, 24:1625-1635.
Nan X, Campoy FJ, and Bird A. 1997. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell,88:471-481.
Forneris F, Binda C, Vanoni MA, Battaglioli E, and Mattevi A. 2005. Human histone demethylase LSD1 reads the histone code. J Biol Chem.280:41360-41365
Ben-Porath I and Cedar H. 2001. Epigenetic crosstalk. Mol Cell,8:933-935.
Vaissière T, Sawan C, and Herceg Z. 2008. Epige- netic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res, 659:40-48.
Chen WY, Bailey EC, McCune SL, Dong JY, and Townes TM. 1997. Reactivation of silenced, vi- rally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci USA, 94:5798-5803.
Hsu CC, Li HP, Hung YH, Leu YW, Wu WH, Wang FS, Lee KD, Chang PJ, Wu CS, Lu YJ, Huang THM, Chang YS, and Hsiao SH. 2010. Targeted methy- lation of CMV and E1A viral promoters. Biochem Biophys Res Commun, 402:228-234.
Mehta AK, Majumdar SS, Alam P, Gulati N, and Brahmacari V. 2009. Epigenetic regulation of cy- tomegalovirus major immediate-early promoter activity in transgenic mice. Gene, 428:20-24.
Yoo YG, Kong G, and Lee MO. 2006. Metastasis- associated protein 1 enhances stability of hypoxia-inducible factor-1 alpha protein by recruiting histone deacetylase 1.EMBO J,25:1231-1241.
Egger G, Liang G, Aparicio A, and Jones PA. 2004. Epigenetics in human disease and prospects for epigenetic therapy. Nature,429:457-463.
Herveldt V, De Mees C, Scohy S, Van Vooren P, Szpirer J, and Szpirer C. 2007. The Sp6 locus uses several promoters and generates sense and an- tisense transcripts. Biochimie, 89:1381-1387.
Feng YQ, Desprat R, Fu H, Olivier E, and Lin CM. 2006. DNA methylation supports intrinsic epigenetic memory in mammalian cells. Plos Genetics, 2:e65 doi:10.1371/journal.pgen.0020065
DOI: https://doi.org/10.22146/theindjdentres.10009
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