Resistensi Antiplatelet pada Stroke Iskemik
https://doi.org/10.22146/bns.v18i1.55067 Nurul Rakhmawati(1*), Paryono Paryono(2), Indarwati Setyaningsih(3)
(1)
(2) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(3) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
Aspirin dan clopidogrel merupakan agen antiplatelet yang sering digunakan pada stroke iskemik. Terdapatnya resistensi antiplatelet menjadi penyebab terjadinya stroke rekuren yang telah rutin minum obat. Persentase terjadinya resistensi antiplatelet pada beberapa penelitian sangat bervariasi mulai 3-85% pada aspirin dan 28-44% pada clopidogrel. Mekanisme yang mendasari terjadinya resistensi antiplatelet belum diketahui dengan pasti. Underdiagnosed resistensi antiplatelet pada kasus rekuren stroke iskemik, belum adanya penelitian, dan pembahasan resistensi antiplatelet pada stroke iskemik di Indonesia mendorong penulis untuk melakukan penulisan tinjauan pustaka.
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DOI: https://doi.org/10.22146/bns.v18i1.55067
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