Korelasi Kadar Asam Urat Serum Dengan Keparahan Neuropati Perifer Diabetik
https://doi.org/10.22146/bns.v18i1.55065 Lia Amalia(1*), Yudiyanta Yudiyanta(2), Indarwati Setyaningsih(3)
(1)
(2) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(3) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
Neuropati diabetik adalah komplikasi kronis diabetes yang paling banyak ditemui. Penilaian dan evaluasi keparahan neuropati diabetik diperlukan pada setiap pasien neuropati perifer diabetik. NDS-INA dapat digunakan untuk menilai derajat keparahan neuropati perifer diabetik. Terdapat hubungan antara kadar asam urat serum dengan kejadian neuropati perifer diabetik, namun korelasinya dengan tingkat keparahan neuropati belum diketahui. Penelitianini bertujuan untuk mengukur koefisien korelasi antara kadar asam urat serum dengan keparahan neuropati perifer diabetik yang diukur dengan NDS-INA.
Penelitian ini merupakan penelitian cross sectional, subjek penelitian adalah pasien neuropati perifer diabetik di poliklinik Saraf dan bangsal perawatan Saraf RSUP Dr. Sardjito Yogyakarta yang memenuhi kriteria inklusi dan eksklusi. Subjek dilakukan pemeriksaan kadar asam urat serum dan penilaian NDS-INA. Korelasi antara kadar asam urat serum, variabel demografi dan laboratorium dengan skor NDS-INA dilakukan dengan uji korelasi Spearman dilanjutkan uji regresi linier.
Didapatkan 57 subjek penelitian, rerata kadar asam urat serum 6,27±1,77; rerata skor NDS-INA 6,39±2,12 dan median 6 (4-10). Hasil uji korelasi bivariat yang signifikan adalah korelasi antara kadar asam urat serum dengan skor NDS-INA (r =0,263; p =0,048), kadar HbA1c dengan skor NDS-INA (r =0,322; p =0,015) dan durasi DM dengan skor NDS-INA (r =0,311; p =0,019). Pada uji multivariat, kadar HbA1c dan durasi DM berkorelasi signifikan dengan skor NDS-INA (masing-masing B =0,355; p =0,004 dan B =0,323; p =0,011), sementara kadar asam urat serum tidak menunjukkan korelasi ysng signifikan dengan skor NDS-INA (B =0,090; p =0,481).
Simpulan penelitian ini, tidak terdapat korelasi positif yang bermakna secara statistik antara kadar asam urat serum dengan keparahan neuropati perifer diabetik berdasarkan NDS-INA.
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DOI: https://doi.org/10.22146/bns.v18i1.55065
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