Pengaruh kadar albumin terhadap tingkat keparahan taxanes induced peripheral neuropathy pada kanker payudara
https://doi.org/10.22146/bns.v18i3.55026 Nur Cahyani Setiawati(1*), Yudiyanta Yudiyanta(2), Samekto Wibowo(3)
(1) KSM Saraf RSUD dr. Soehadi Prijonegoro, Sragen
(2) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(3) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
Toksisitas jangka panjang pengobatan kanker yang terpenting adalah chemotherapy induced peripheral neuropathy (CIPN), 40% menyebabkan gejala dan kecacatan permanen. Pasien kanker dengan kemoterapi taxanes 80% mengalami taxanes induced peripheral neuropathy (TIPN). Kadar albumin rendah, terbukti berhubungan dengan pengembangan toksisitas kemoterapi. Kadar serum albumin merupakan pemeriksaan rutin sebelum kemoterapi, diharapkan dapat sebagai prediktor CIPN.
Penelitian ini bertujuan mengetahui pengaruh kadar albumin terhadap tingkat keparahan CIPN pada kanker payudara yang mendapat kemoterapi taxanes RSUP Dr. Sardjito Yogyakarta. Rancangan penelitian observasional kohort retrospektif, dengan subjek kanker payudara yang telah selesai 6 siklus kemoterapi taxanes di Poli Kanker Terpadu Tulip. Tingkat keparahan CIPN dinilai menggunakan skor neuropati NCI-CTC versi 3.0. Kadar albumin diperiksa di Instalasi Patologi Klinik sebelum menjalani kemoterapi. Seluruh data kemudian diolah untuk analisis statistik secara komputerisasi.
Sebanyak 50 subjek mengikuti penelitian dengan rerata usia 51,52±10,05 tahun dan kadar albumin 4,07±0,47 g/dL. Hasil analisis bivariat didapatkan 2 faktor bermakna secara signifikan mempengaruhi tingkat keparahan CIPN baik sensorik maupun motorik yaitu kadar albumin (neuropati sensorik p =0,002, motorik p =0,002) dan usia (neuropati sensorik p =0,039 dan motorik p =0,001). Setelah dilakukan analisis multivariat menunjukkan bahwa hanya kadar albumin (neuropati sensorik p =0,009 dan motorik p =0,010) yang merupakan faktor independen yang mempengaruhi tingkat keparahan CIPN
Berdasarkan penelitian ini, terdapat pengaruh kadar albumin terhadap tingkat keparahan CIPN, yaitu kadar albumin yang lebih rendah memiliki tingkat CIPN yang lebih parah.
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DOI: https://doi.org/10.22146/bns.v18i3.55026
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