Ketahanan hidup dua tahun pasien tuberkulosis resisten obat di RS. Moewardi Surakarta tahun 2010-2014

https://doi.org/10.22146/bkm.22462

Artika Fristi Firnawati(1*), Riris Andono Ahmad(2), Heni Retnowulan(3)

(1) Department of Biostatistics, Epidemiology, and Population Health Faculty of Medicine, Universitas Gadjah Mada
(2) Department of Biostatistics, Epidemiology, and Population Health Faculty of Medicine, Universitas Gadjah Mada
(3) Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Two year survival of drug resistant tuberculosis patients in Moewardi hospital in Surakarta in 2010-2014

Purpose

The purpose of this study was to determine the two year survival rate and predictor factors of mortality in drug resistant tuberculosis patients during treatment at the Moewardi Hospital in Surakarta.

Methods

This research was a retrospective cohort study of 250 drug resistant tuberculosis patients receiving treatment in the Moewardi Hospital in January 2011-September 2014. Data were analyzed using survival analysis to find factors affecting the 2 year survival. Our variables were demographic factors, disease characteristics and treatment history. We used Cox regression test with 5% significance level.

Results

2-year survival rates of drug resistant patients was 74.82%. age, the type of patient, HIV status, side effects of medications and culture conversion were significant to survival rate in bivariate analysis. Cox regression test showed that aged ≥ 40 years (HR 3.221; 95% CI 1.037 to 10.001) and have HIV-positive status (HR 18.086; 95% CI 1.958 to 167.073) were related with reduction of two year survival rate in drug resistant tuberculosis patient.

Conclusion

Age above 40 years old and HIV positive status for drug-resistant tuberculosis patients may accelerate their death. The screening of HIV in drug resistant tuberculosis patients is needed in order to increase two year survival rate of patients during treatment.


Keywords


tuberculosis; survival life; drug resistant



References

  1. Curry International Tuberculosis Center. Drug-Resistant Tuberculosis a Survival Guide for Clinicians. In: Clinics in Chest Medicine. 2nd ed. California Department of Public Health; 2011. www.currytbcenter.ucsf.edu/drtb.
  2. Kementerian Kesehatan RI. Petunjuk Teknik Manajemen Terpadu Pengendalian Tuberkulosis Resistan Obat. Jakarta: Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan; 2013. doi:10.1017/CBO9781107415324.004.
  3. Soepandi, P Z. Diagnosis dan Penatalaksanaan Tb - MDR. Cermin Dunia Kesehat. 2010;37(7):497-501.
  4. WHO. Companion Handbook To The WHO Guidelines For The Programmatic Management Of Drug-Resistant Tuberculosis. Geneva; 2014.
  5. WHO. Multidrug Resistant Tuberculosis (MDR-TB) 2015 Update.; 2015.
  6. WHO. Global Tuberculosis Report 2015. Vol 1. 20th ed.; 2015. doi:10.1017/CBO9781107415324.004.
  7. Kemenkes RI. Tuberkulosis Temukan Obati Sampai Sembuh. Infodatin. 2015:2-3. http://www.depkes.go.id/download.php?file=download/pusdatin/infodatin/infodatin_tb.pdf.
  8. Ratna. Profil Program Pengendalian TB Propinsi Jawa Tengah. Surakarta: P2TB Jawa Tengah; 2014.
  9. Kementerian Kesehatan RI. Pedoman Nasional Pengendalian Tuberkulosis. Jakarta: Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan; 2014.
  10. Kim DH, Kim HJ, Park S-K, et al. Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosis. Am J Respir Crit Care Med. 2008;178(10):1075-1082. doi:10.1164/rccm.200801-132OC.
  11. Balabanova Y, Radiulyte B, Davidaviciene E, et al. Survival of Drug Resistant Tuberculosis Patients in Lithuania: Retrospective National Cohort Study. BMJ Open. 2011;1(2):e000351-e000351. doi:10.1136/bmjopen-2011-000351.
  12. Anderson LF, Tamne S, Watson JP, et al. Treatment Outcome of Multi-drug Resistant Tuberculosis in The United Kingdom: Retrospective-Prospective Cohort Study From 2004 to 2007. Euro Surveill. 2013;18(40):1-10. doi:10.2807/1560-7917.ES2013.18.40.20601.
  13. Getachew T, Bayray A, Weldearegay B. Survival and Predictors of Mortality Among Patients Under Multi-drug Resistant Tuberculosis Treatment in Ethiopia: St. Peter’s Specialized Tuberculosis Hospital, Ethiopia. Int J Pharm Sci Res. 2013;4(2):776-787.
  14. Charles M, Vilbrun SC, Koenig SP, et al. Treatment Outcomes for Patients with Multidrug-Resistant Tuberculosis in Post-Earthquake Port-au-Prince, Haiti. Am J Trop Med Hyg. 2014;91(4):715-721. doi:10.4269/ajtmh.14-0161.
  15. Sun Y, Harley D, Vally H, Sleigh A. Comparison of Characteristics and Mortality in Multidrug Resistant (MDR) and Non-MDR Tuberculosis Patients in China. BMC Public Health. 2015;15(1):1027. doi:10.1186/s12889-015-2327-8.
  16. Milanov V, Falzon D, Zamfirova M, et al. Factors associated with treatment success and death in cases with multidrug-resistant tuberculosis in Bulgaria, 2009-2010. Int J Mycobacteriology. 2015;4(2):131-137. doi:10.1016/j.ijmyco.2015.03.005.
  17. Gadallah MA, Mokhtar A, Rady M, El-Moghazy E, Fawzy M, Kandil SK. Prognostic Factors of Treatment among Patients with Multidrug-Resistant Tuberculosis in Egypt. J Formos Med Assoc. 2015:1-7. doi:10.1016/j.jfma.2015.10.002.
  18. Lockman S, Kruuner A, Binkin N, et al. Clinical Outcomes of Estonian Patients with Primary Multidrug-Resistant versus Drug-Susceptible Tuberculosis. Clin Infect Dis. 2001;32(3):373-380. doi:10.1086/318489.
  19. Fatmah. Respons Imunitas yang Rendah pada Tubuh Manusia Usia Lanjut. Makara Kesehat. 2006;10(1):47-53.
  20. Khan MA, Mehreen S, Basit A, Khan RA, Javaid A. Predictors of Poor Outcomes among Patients Treated for Multidrug-Resistant Tuberculosis at Tertiary Care Hospital in Pakistan. 2015;7(3):162-172. doi:10.5829/idosi.aejts.2015.7.3.9499.
  21. Kurbatova E V, Taylor A, Gammino VM, et al. Predictors of poor outcomes among patients treated for multidrug-resistant tuberculosis at DOTS-plus projects. Tuberculosis. 2012;92(5):397-403. doi:10.1016/j.tube.2012.06.003.
  22. Jain K, Desai M, Solanki R, Dikshit RK. Treatment outcome of standardized regimen in patients with multidrug resistant tuberculosis. 2014;5(2):145-149. doi:10.4103/0976-500X.130062.
  23. Siswanto; Reviono; Aphridasari, Jatu; Susanto YS. Faktor Prediktor Hasil Akhir Pengobatan Pasien Tuberkulosis Resisten Obat di RSUD Dr Moewardi Surakarta. 2016:1-13.
  24. Tang S, Tan S, Yao L, et al. Risk Factors for Poor Treatment Outcomes in Patients with MDR-TB and XDR-TB in China : Retrospective Multi- Center Investigation. 2013;8(12):1-8. doi:10.1371/journal.pone.0082943.
  25. Leimane V, Riekstina V, Holtz TH, et al. Clinical Outcome of Individualised Treatment of Multidrug Resistant Tuberculosis in Latvia : A Retrospective Cohort Study. Lancet. 2005;365.



DOI: https://doi.org/10.22146/bkm.22462

Article Metrics

Abstract views : 1881 | views : 1424

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2017 Berita Kedokteran Masyarakat



Berita Kedokteran Masyarakat ISSN 0215-1936 (PRINT), ISSN: 2614-8412 (ONLINE).

Indexed by:

 

Web Analytics Visitor Counter