2024-03-29T00:27:52Z
https://jurnal.ugm.ac.id/bik/oai
oai:jurnal.ugm.ac.id:article/2980
2019-11-12T01:28:45Z
bik:ART
The influence of stigma and depression on quality of life of leprosy patients
Agnes S. Siswati, Jenny MC Siagian, Carla R Marchira
Background: Stigma attached to leprosy-affected individuals is one of the strongest stigma of diseases. Depression is often occurred to many lepers. Stigma and depression are two factors which affect the quality of life of the lepers. Objective: To determine whether stigma and depression affect the quality of life of leprosy patients in Dermatovenereology outpatient clinic at RSUP Dr Sardjito Hospital. Methods: It was a quantitative and cross-sectional research. The quantitative analysis was conducted with chi-square and multiple regression methods. Result: There was no significant correlation between stigma and quality of life of leprosy patients. The factors which significantly correlated with quality of life were gender, income, and depression score (p < 0.051. Depression score significantly affected the quality of life (B 1.876; P < 0.05; CI 1.166-36.5661. Conclusion: Depression affected the quality of life more than deformity and demographic factors among leprosy patients in Dermatovenereology outpatient clinic at RSUP Dr Sardjito Yogyakarta. Key words: stigma - depression - lepro
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/2980
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 41, No 01 (2009)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 41, No 01 (2009)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/2980/pdf
Copyright (c) 2015 Jenny MC Siagian, Carla R Marchira Agnes S. Siswati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/2982
2019-06-17T07:29:19Z
bik:ART
Standardization of Immunocytochemical method for the diagnosis of Dengue Viral Infection in Aedes aegypti Linn Mosquitoes (Diptera Culicidane)
Umniyati, Sitti Rahmah
methods for virus detection in the mosquito, such as the direct fluorescent-antibody test on head squashes. However, it has the disadvantages of being labor-intensive and requiring fluorescent microscope as well as cryofreezer. Newer methods involving enzyme conjugates such as peroxidase in conjunction with either polyclonal or monoclonal antibodies are greatly improved. With new methods of immunocytochemistry, it is now possible to detect dengue viral antigen in a variety of tissues. Objective: This study was aimed to standardize an immunocytochemical streptavidin-biotin-peroxidasecomplex assay for diagnosis of dengue infection in Aedes aegypti using monoclonal antibody DSSC7. Methods: The infected mosquitoes were held in small cylindrical cages covered with mosquito netting, and incubated at 27:t 1°C ami at relative humidity of 88:t 6 %. The specificity of the immunocytochemical procedure was validated by negative and positive controls showing that the antibody was bound to an appropriate structure. The sensitivity and specificity were also evaluated based on Herrmann's Formula. The presence of dengue antigen on head squash preparation was detected based on ISBPC assay using monoclonal antibody against dengue. The validity and reliability of the measurement were evaluated based on kappa values, according to Landis and Koch. Result: Positive result was detected as discrete brownish granular deposits throughout most visual fields of brain tissue. Dengue viral antigen was immunolocalized to the cytoplasm of brain cells. The immunocytochemical test under light microscope at magnification of 400x was 86.67% sensitive, 96.00% specific, and the kappa value is 0.64. Meanwhile the kappa value between two observers was 0.92, with sensitivity and specificity of 96% and 97% respectively at magnification of 1000x. Conclusion: The monoclonal antibody DSSC7 was sensitive, specific, valid, and reliable as primary antibody to detect dengue viral infection in Ae. aegypti head squash preparation based on immunocytochemical streptavidin-biotin-peroxidase-complex assay under light microscope. Key words: antigen - denguevirus - Aedes aegypti - immunocytochemistry - monoclonal antibody DSSC7
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/2982
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 41, No 01 (2009)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 41, No 01 (2009)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/2982/pdf
Copyright (c) 2015 Sitti Rahmah Umniyati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/4082
2019-10-07T08:08:11Z
bik:ART
Risk factors of constipation in children
Dyah Kurniati, Dyah Kurniati
Background: Despite it is not considered as a dangerous situation in children older than 2 years old, but attention is important in young infant. Improper treatment in constipation may contributed to the raise of anxiety, emotionally disorder either for the children or its relatives.Objective: To determine risk factors related to constipation in children.Design and Methods: A case control study was conducted for all of children who were admitted to ambulatory polyclinic and inpatient clinic of Sardjito Hospital during January 2001 - December 2001. A questionnaire was obtained by the researcher or assistant by direct interview to parent or guardian.Results: We enrolled 86 children, consisted of 43 children in constipation group and the43 children as control. There was significant difference (p < 0.01) between two groups in the presence of the symp-toms (abdominal pain, pain during defecation, vomit, decrease of appetite and encopresis). More childrenin constipation group and significant difference (p<0.01) when reported having toilet training distur- bance, daily fluid intake, the variety of daily meals (vegetables, fruits) and sweetened foods. Relative risk of having constipation due to toilet training disturbance in constipations group is 0.14 (CI: 0.06 - 0.38).Conclusion: Toilet training disturbance, daily fluid intake, the variability of daily meals and sweetened foods are risk factors of constipation in childhood.Key words: children - constipation - clinical findings- risk factors
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/4082
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
2356-3931
ind
https://jurnal.ugm.ac.id/bik/article/view/4082/3356
Copyright (c) 2015 Dyah Kurniati Dyah Kurniati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/4083
2019-10-07T08:08:11Z
bik:ART
Death: clinical and forensic anthropological perspectives
Etty Indriati, Etty Indriati
All biological living beings inevitably die, and the ways to die vary although in essence death is a manifestation of the absence of Oxygen in the brain. After death, biological remains undertake proteolysis and decomposition. The aim of this article is to discuss clinical death, cerebral or medicolegal death, social death, phases of cerebral death, and biological process after death—which is important for forensic medicine and forensic anthropology. How long a person die, if the time elapsed is in minutes, hours, days and a week,-it is within the field of medical forensic and pathological forensic. If the time elapsed after death is in weeks, months, or years, it is within the field of forensic anthropology. The time elapsed from biological death to the examination of the death is called postmortem interval. Five case studies on postmortem interval are presented in this article. It can be concluded that knowledge of the biological process of death and the fate of biological remains after death are important for handling abnormal death both in forensic medicine and forensic anthropology.Key words: clinical death, cerebral death, postmortem interval, forensic medicine, forensic anthropology
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/4083
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
2356-3931
ind
https://jurnal.ugm.ac.id/bik/article/view/4083/3361
Copyright (c) 2015 Etty Indriati Etty Indriati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/4086
2019-10-07T08:08:11Z
bik:ART
Identification and test of active protein resemble Ribosomr-inactivating proteins (RIPs) on Kaemferia rotunda Linn
Wiryatun Lestariana, Wiryatun Lestariana
Background: Statistically data of US Mortality showed that percentage cause of the death of the cancer is in second place after the heart diseases. Indonesia, Java especially Daerah Istimewa Yogyakarta, the data of The Dr. Sardjito hospital showed that the patients of cancer was increasing in the last year. Indonesian, especially Javanese, uses white turmeric to prevent and to treat cancer. There are some varieties of turmeric available commercially such as Curcuma (Cl mangga Val & Jijp, C. zeodaria and Kaemferia (K) rotunda Linn. The studies showed that C. mangga contain proteins compound that resembles Ribosome-inactivating proteins (RIPs) which have activity to cleave supercoiled DNA. In vitro study indicated that the addition of crude extract of C. mangga on cancer cell-lines (B-LCL, EBV cells and Raji cell-lines) and normal lymphocytes, the percentage of cytotoxic effect on those cancer cell-lines were higher significantly than normal cells.Objective: The aim of the study was to know the presence of RIPs activity in K. rotunda Linn by the ability of the RIPs in cleaving the supercoiled DNA.Methods: The rhizomes of K. rotunda Linn that was in part dried at 40°C. Both wet and dried rhizomes are pounded and then extracted. The resulting crude extract was precipitated to obtain its protein fraction. The crude extract and protein with various concentrations were incubated with the supercoiled DNA and agarose gel electrophoresis was used to test its activity in cleaving the supercoiled DNA. The activity test was done by observing 3 criterions, viz. the thinning of the supercoiled DNA, the circular band thickening and the appearance of the linear band which were subsequently compared to the plasmid DNA without treatment.Result: The results showed that both crude extracts and proteins of both wet and dried samples were able to cleave supercoiled DNA into circular and linear form. The increasing concentrations of the crude extract and the protein resulted in increasing the activity which was indicated by the thickening of circular band and the appearance of the linear band .Conclusion: Kaemferia rotunda contains proteins compound that resemble Ribosome-inactivating proteins (RIPs).which have ability to cleave supercoiled DNA to be circular and linear DNA.Key words: ribosome-inactivating proteins (RIPs) - supercoiled DNA - circular DNA - linear DNA - Kaemferia rotunda Linn
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/4086
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/4086/pdf
Copyright (c) 2015 Wiryatun Lestariana Wiryatun Lestariana
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/4087
2019-10-07T08:12:11Z
bik:ART
The effect of 2% salicylic acid as a support of 10% benzoil peroxide gel for mild to moderate acne vulgaris.
Rahajeng Musy, Rahajeng Musy
Background: Cleansing is necessary before the application of topical therapy for acne vulgaris. However ordinary soap leads to dryness. Two percent salicylic acid has comedolytic, anti inflammation and moisturizing activity.Objective: The aim of this study was to assess the effectiveness of 2% salicylic acid soap as a support of 10% benzoil peroxide gel for mild to moderate acne vulgaris.Material and method: The design of this study was randomized, double blind, clinical trial. Fifty twofemales with mild to moderate acne vulgaris with the mean of the age was 18.9 ± 3.06 years old were divided into 2 groups. The first group was treated with 2% salicylic acid soap and the second group was treated with soap base, in addition to 10% benzoil peroxide gel for both groups. The clinical assessment was conducted by counting the acne lesion at 2, 4, 8, and 12 week. While the level of moisture and sebum of the skin was measured by corneometer and sebumeter of Courage – Khazaka at 4, 8, and 12 week. The difference between 2 groups was analyzed statistically by t-test, chi-square test and Mann-Whitney U test. The difference was considered to be significant if p < 0.05.Result: There was significant reduction of the open comedone in salicylic acid soap group
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/4087
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/4087/pdf
Copyright (c) 2015 Rahajeng Musy Rahajeng Musy
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/4088
2019-10-07T08:08:11Z
bik:ART
Profile of patients diagnosed as sepsis (ICD X: A41.9) in the Internal Medicine Ward Sardjito Hospital in 2002
Yanri Wijayanti Subroto, Yanri Wijayanti Subroto
Background: Sardjito Hospital as the top referral hospital for the Yogyakarta Special Province and the southern part of Central Java has a mortality rate of 56.83% of patients diagnosed as sepsis (ICD X A41.9). The overall hospital sepsis case in the year 2002 was 275, with 50.54% (139) of which was treated in the Internal Medicine ward. Out of the 139 cases, 44.60% was man and 55.40% was woman. Method: This study was focused on the identification of demographic and clinical factors of patients diagnosed as sepsis (ICD X A41.9) in Internal. Medicine ward Sardjito Hospital in 2002. Demographic data include sex, age, system of hospital admission (referral or self admition. Clinical data include the concomitant disease(s), causes of death, and type of cultured microorganism(s). The identification of these factors may be beneficial for designing an early warning system for fatal cases of patients with sepsisResults: Only 120 (86.33%) out of 139 medical records were eligible for further analysis. Seventy-one (59.17%) patients died in the hospital, whereas 49 (40.83%) were discharged from the hospital, but mostly were forced leave (only 6 patients were discharged in a good condition). The median ± SD age was 53.5 ± 15.99 years old with the youngest age was 17 and the oldest was 98. More than 50% of patients were above 50 years old. As many as 72 (60%) patients were admitted to the hospital referred by other hospitals (a few numbers were referred by private physicians), and only 48 (40%) patients were self-admitted. The average length of hospitalization was 6.96 ± 5.43 days, with the range of 1-25 days. The cause of death of these patients were mostly septic shock (61.97%), followed by respiratory failure (19.72%), intracranial process (14%), cardiac arrest (2.8%) and MOFS (1.4%). The underlying/concomitant diseases are:. gastrohepatology (mostly hepatic cirrhosis and hepatocellular carcinoma); hematology (acute leukemia, multiple myeloma), pulmonology (TB, COPD, pneumonia), oncology (Ca mammae, Ca cervix); endocrinology (DM type 2 with ulcus diabeticum), nephrology (chronic renal failure), cardiology (congestive heart failure), obsgyn (septic puerpuralis) and trop-med (urinary tract infection, malaria), etc.Conclusion: We report here research on medical record of patients diagnosed as sepsis (ICD X: A41.9) in Internal Medicine ward Dr. Sardjito Hospital in 2002. There were 139 cases with only 120 were eligible for analysis. Mortality reached 59.17% of cases with median of age 53.5 years and average length of hospitalization of 6.96 days. The most common cause of death was septic shock and gastrohepatology as the most common comorbid disease.Key words: sepsis-demographic-clinical presentation-cause of death
Universitas Gadjah Mada
2015-11-18
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/4088
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 35, No 4 (2003)
2356-3931
ind
https://jurnal.ugm.ac.id/bik/article/view/4088/3367
Copyright (c) 2015 Yanri Wijayanti Subroto Yanri Wijayanti Subroto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/6377
2019-05-21T07:15:38Z
bik:ART
Ephaptic crosstalk in Painful Diabetic Neuropathy: an electrodiagnostic study.
Asmedi, Ahmad
Wibowo, Samekto
Meliala, Lucas
Painful diabetic neuropathy – NCS – ephaptic– Diabetes Mellitus
Painful Diabetic Neuropathy (PDN) is a common complication of diabetes mellitus(DM) which significantly causes pain and distress in patients. Release of factors fromdegenerating fibers activating adjacent fibers to produce ephaptic crosstalk have beenproposed as one of the pain mechanism in PDN. Here we aim to detect ephaptic crosstalkbetween small fibers and large fibers in PDN subjects by comparing the electrodiagnosticresult of patients with PDN and patients without PDN.This study used cohort prospective design. Patients with type 2 DM or impairedglucose tolerance (IGT) without PDN from several health facilities in Yogyakarta werefollowed for 12 months for the occurrence of PDN. Demographic, clinical, laboratory andelectrodiagnostic data from all patients were collected and analyzed.One hundred and forty-one subjects (58 men, 83 women) with an average age of 51years (range, 40–61 years), were enrolled in this study. After 48 weeks of observation,12 subjects were found to have PDN. The differences of distal latency between PDNand non-PDN group were significant when measured in median sensory nerve (4.47 ms±2.43 versus 3.39 ms ±1.79, p = 0.002), tibial motor nerve (6.96 ms ±3.07 versus5.90 ms ±2.17, p = 0.041), and sural sensory nerve (6.02 ms ±3.56 versus 3.55ms ±2.90, p <0.001). Among all parameters measured in this study, the H-reflex hadhigher abnormality persentage compared to other electrodiagnostic variable (H latency =30%, H amplitude = 71%, H/M Ratio = 88%, and H-M IPL = 15%).Our result shows that small fiber neuropathy in PDN can be detected by electrodiagnosticstudy which measures large fibers function. This indicates that ephaptic crosstalkbetween small fiber and large fiber happens in PDN.
Universitas Gadjah Mada
2018-04-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/6377
10.19106/JMedSci005002201806
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/6377/pdf
Copyright (c) 2018 Ahmad Asmedi, Samekto Wibowo, Lucas Meliala
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/6480
2019-11-14T07:32:11Z
bik:ART
Prognostic factors for heart valve surgery outcomes in Dr Sardjito General Hospital Yogyakarta, Indonesia
Priyatno, Wahyu
Supomo, .
Heart valve disease is a serious health probem due its significant effect on mortality.Surgical intervention plays an importan roleinthe management of moderate to the severe valvular heart disease. The evaluation of the patientoutcomes has been widely accepted as one of the important steps to improve the quality of patient care.Recognition of post operative complications might significantly affect the patient quality of life.Therefore, the identification of prognostic factors and morbidity of heart surgery patients can provide valuable insights on improving the quality of patient care.This study aimedto investigat the prognostic factors for heart valve surgery outcomes in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. This study was conducted using data ofpatient’s medical records who underwent heart valve surgeryincluded morbidities and their prognostic factors.The data were analyzed using Chi-square test and logistic regression with significance level of 0.05. During 2010 to 2014, 82 patients underwent heart valve surgeries at the hospital. The kidney disorders and heart failure were significantly associated with the patient morbidity (p<0.05),while the gender, pulmonary disease, angina, and impaired ventricular function were not (p>0.05). Multivariate analysis showed that the heart failure is the most significant factor of morbidity. The risk of New York Heart Association (NYHA) class 3 patients were 7.18 times compared with NYHA class 2 patients. In conclusion, the heart failure is the most significant factor for the morbidityof heart valve surgery followed by the kidney disorders at the Dr. Sardjito General Hospital.
Universitas Gadjah Mada
2017-02-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/6480
10.19106/JMedSci005102201908
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 159-163
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 159-163
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/6480/pdf
Copyright (c) 2017 Wahyu Priyatno, . Supomo
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/11419
2019-08-05T07:20:12Z
bik:ART
The frequency of DISC1 Leu607Phe gene polymorphism in schizophrenia patients at Dr. Soetomo General Hospital Surabaya
Prabowo, gwenny Ichsan
Maramis, Margarita Maria
Yulianti, Erikavitri
Zulaikah, Afrina
Syulthoni, Zain Budi
Margono, Hendy Muagiri
Handajani, Retno
Schizophrenia; DISC1 Leu607Phe gene; polymorphism; PANSS; predisposition
Psychiatry
Schizophrenia is a common health problem in the world, including in Indonesia.Polymorphism of gene disrupted in schizophrenia 1 (DISC1) Leu607Phe is allegedly relatedto the predisposition to schizophrenia. However, studies on the relationship betweenpolymorphism of DISC1 Leu607Phe and schizophrenia in various etnics provided differentresults. The purpose of this study was to determine the frequency of DISC1 Leu607Phegenepolymorphism and its association with treatment response in patients with schizophreniaat Department of Psychiatry, Dr. Soetomo General Hospital Surabaya. In this study, thenumber of male patients with schizophrenia was more than that of the female patients.The mean age of male patients with schizophenia was lower than that of the femalepatients. Schizophrenia patients were primarily came from Javanese ethnic with positiveand negative symptom score (PANSS) lower in male patients than that in the femalepatients. In conclusion, no DISC1 gene polymorphism at codon 607 is observed inschizophrenia patients at Dr. Soetomo General Hospital Surabaya, but the G nucleotidevariation at the number 196.339 in intron regions is found instead.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/11419
10.19106/JMedSci005001201802
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/11419/pdf
Copyright (c) 2018 gwenny Ichsan Prabowo, Margarita Maria Maramis, Erikavitri Yulianti, Afrina Zulaikah, Zain Budi Syulthoni, Hendy Muagiri Margono, Retno Handajani
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/11997
2018-12-20T03:00:34Z
bik:ART
Severity and treatment level of acute gastroenteritis with rotavirus in children under 5 years in INDONESIA
Gdara, Fatma Othman
At Thobari, Jarir
Soenarto, Yati
rotavirus - acute gastroentrities - treatment level - vesikari score - children
Rotavirus diarrhea causing gastroenteritis in children under five years is an importantissue that urgently needs to be addressed globally. Delay in management of rotavirusdiarrhea can be fatal. Diagnostic tool for detecting rotavirus is, therefore, needed.However, until now the gold standard diagnostic tools are expensive, often not availableand affordable in health care settings. The aim of the study was to compare the Vesikariclinical severity score of rotavirus-positive with rotavirus-negative in hospitalized childrenwith acute gastroenteritis. Furthermore, the difference of the level of treatment betweenrotavirus-positive with rotavirus-negative was also evaluated. This was a cross sectionalstudy that using secondary data from medical records of five general teaching hospital inIndonesia. Subjects were children aged <5 years with acute watery diarrhea admitted tothe hospital. Statistical analysis used was chi square test, U-Mann Whitney, and KruskalWallis. The results showed that the patient with rotavirus positive have higher dehydration(80.2%) compared to rotavirus negative (70%). The severity level of clinical feature washigher in diarrhea due to rotavirus positive than non rotavirus (11.47± 2.89 vs 10.41± 2.70; p<0.000). The level of treatment was higher in rotavirus positive. The majorityhad treatment plan C (47.7%) higher than plan B and A (45.6% and 30.9%; p<0.050).This was opposite with patient with rotavirus negative that majority had treatment inplan A (69.1%) higher than plan B and C (54.4% and 52.3%) (p<0.001). In conclusion,the severity of gastroentrities in children under 5 years using vesikari score are higher indiarrhea due to rotavirus positive than non rotavirus. The treatment level plan C is higherthan plan B and A in diarrhea due to rotavirus. This is opposite with non rotavirus majorityhave treatment in plan A higher than plan B and C.
Universitas Gadjah Mada
2018-04-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/11997
10.19106/JMedSci005001201812
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/11997/pdf
10.19106/10.19106/JMedSci005001201812
Copyright (c) 2018 Fatma Othman Gdara, Jarir At Thobari, Yati Soenarto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12055
2018-06-19T00:03:59Z
bik:ART
Comparing P-Selectin (CD62P) expression in patients receiving non-leukodepleted vs leukodepleted thrombocyte concentrates
Triyono, Teguh
Mulyono, Budi
Sutaryo, .
Sofro, Abdul Salam
thrombocyte conentrate – transfusion – CD62P expression - thrombocytopenia – adverse effect
Thrombocyte concentrate (TC) transfusion is an important supportive therapy in patients with thrombocytopenia. The risks in platelet transfusions may be related to the content of TC including the contaminant leukocytes. The aim of this study was to assess the risk of increased level of P-Selectin (CD62P) expression of non-leukodepleted TC transfusions.This was a quasi-experimental study. Subjects were children patients aged 1-18 years who received a non-leukodepleted or a leukodepleted TC transfusions. Comparison of the proportion of increased expression of CD62P in both groups expressed as relative risk. The subjects consisted of 51 patients who received non-leukodepleted and 52 patients who received leukodepleted TC transfusions. The risk of increased expression of CD62P in patients receiving non-leukodepleted TC transfusions were 2.38 (95%CI:1.60-3.53) times higher than those who received leukodepleted TC. Non-leukodepleted have significant higher risks of increased CD62P expression than leukodepleted TC transfusions.
Universitas Gadjah Mada
2017-07-19
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12055
10.19106/JMedSci004903201704
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12055/pdf_1
Copyright (c) 2017 Teguh Triyono, Budi Mulyono, . Sutaryo, Abdul Salam Sofro
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12351
2019-10-31T02:47:45Z
bik:ART
Patient prognosis after relief of obstruction
Danarto, R
obstructive uropathy - prognostic factors - kidney recovery – ureteral stent – relief obstruction
ABSTRACTObstructive uropathy may lead to irreversible kidney damage. The insertion of ureteral stent is one of procedure to relief obstruction and prevent further kidney damaged, septicemia as well as urosepsis. A study to evaluate the predictive factor of urinary diversion in improving kidney function is needed. This study aimed to assess prognosis factors post-relief of obstruction in patients with uropathic obstruction focusing on kidney function recovery. This was a retrospective cohort study conducted at An-Nur Private Hospital in Yogyakarta Special Region, Indonesia using the medical record of patients with obstructive uropathy whom underwent DJ Stent insertion from a period of 2011 to 2015. The data of clinical assessment, laboratory and radiologic examination data were collected and analyzed using Chi square or student t test. A total 59 patients with obstructive uropathy aged around 50.9 years whom underwent DJ Stent were involved in this study. The results showed that release of obstruction with the installation of ureteral stents was significantly able to improve kidney function. The duration of obstruction, etiology, and hemoglobin (Hb) levels were associated with creatinine levels, whereas gender, urinary tract infection (UTI) and comorbid were not. In conclusion, prognosis factors of postrelief obstuction are duration of obstruction, etiology of obstruction and Hb levels before the release of obstruction
Universitas Gadjah Mada
2019-03-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12351
10.19106/JMedScie/005004201803
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12351/pdf
Copyright (c) 2019 R Danarto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12381
2019-10-31T02:47:45Z
bik:ART
Assessment of the normal anal position index (API) of Indonesian neonates
Suryana, Yudi
Makhmudi, Akhmad
anal position index - sex - gestational age – Indonesia - neonate
The existing anal position index (API) data appear to vary among the ethnic differences.Until now, however, the normal API has not been studied in Indonesia. This study aimedto determine the normal value of the API in Indonesian newborns This cross-sectionalstudy was conducted on 62 neonates (29 males and 33 females) without any malformationat Pediatric Surgery Division, Department of Surgery, Dr. Sardjito General Hospital,Yogyakarta during the period September to October 2012. The position of the anus wasnumerically defined by the API, which is the ratio of anus-fourchette distance in females and anus-scrotum distance in males to the distance between coccyx and fourchette/scrotum. To make correct measurements, transparent adhesive tape was used longitudinally on midperinum in a way that it covered the anus. Then fourchette/scrotum, anus center and the lower margin of coccyx were marked on it. Distances marked on each tape were then measured with the standard ruler. Relationship between API and other parameters were analyzed. The API values were 0.46±0.05 (95% CI: 0.44–0.48) for newborn males and 0.37±0.07 (95% CI: 0.35–0.39) for newborn females. The difference of API between males and females was significant (p = 0.000). API had no significant correlation with gestational age (p = 0.350) and birth weight (p = 0.650). Our data suggested the API, which is sex dependent, provides a reliable parameter for determining the position of the anus. API has no correlation with gestational age and birth weight. The determination of normal API in older infants is required to determine whether the API is affected by age.
Universitas Gadjah Mada
2019-01-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12381
10.19106/JMedScie/005004201807
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12381/pdf
Copyright (c) 2019 Yudi Suryana, Akhmad Makhmudi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12396
2019-08-08T06:04:08Z
bik:ART
The effects of duration of mesenteric artery ligation to the ratio of TNF-α/IL-10 in a rat model of acute mesenteric ischemia (AMI)
Handaya, Adeodatus Yuda
Budipramana, Vicky S.
acute mesenteric ischemia – mesenteric artery - TNF-α/IL-10 ratio – biomarker – early diagnosis
The mortality rate of acute mesenteric ischemia (AMI) is high due to the delay in diagnosis.Determination of potent biomarker for early AMI is the key in reducing the mortality. As aproinflammatory cytokine, the level of TNF-α might be affected during the ischemia andreperfusion, with the prediction duration of 60-120 min. High TNF-α level may stimulatethe upregulation of IL-10 as an inhibitor of TNF-α. This provides a new opportunity forearly diagnosis of AMI by measuring the ratio between those two cytokines. The purposeof this study was to investigate the effect of duration of the mesenteric artery to theratio of TNF-α/IL-10 in a AMI rat model. This was an experimental study using Wistarrat. We performed mesenteric artery in 28 male rats to produce an AMI model, withligation duration of 0, 30, 60, 90, 120, 150, and 180 minutes. At the end of ligation,blood samples were taken for measurement of TNF-α and IL-10 level using ELISA. For themicroscopic examination of tissue necrosis, intestinal organ samples were taken and madeinto paraffin blocks and stained using Haematoxylin-Eosin. TNF-α increased in minute 120compared to other treatment groups (p<0.05). IL-10 increased in minute 180 comparedto control group (p<0.05). Microscopic examination showed that the duration of ligationaffects the structure and morphology of intestinal mucosa characterized by discolorationof organs along with increasing the ligation duration. Ligation of the superior mesentericartery was found to be significantly increased the TNF-α level and to be compensated byincreasing IL-10. It is assumed that when the IL-10 level, that has protective effect as aninhibitor, higher than TNF-α level as a proinflammatory cytokine on duration 150 minutes,it means no more inflammatory or cells is dead. Therefore TNF-α/IL-10 ratio can be usedas a biomarker candidate of prognosic factor management of AMI.
Universitas Gadjah Mada
2017-12-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12396
10.19106/JMedSci004904201702
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 165-174
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 165-174
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12396/pdf_1
Copyright (c) 2017 Adeodatus Yuda Handaya, Vicky S. Budipramana
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12577
2019-05-21T07:23:54Z
bik:ART
Prognostic factors affecting the mortality of 2nd and 3rd degree burn injuries at a tertiary care center in Indonesia
Dachlan, Ishandono
Anam, Khoirul
burn injuries – mortality – prognostic factors – tertiary care center - Indonesia
About two million people suffer from burn injuries in the United States eachyear, with 100,000 hospitalized in the burn unit. Around 1000 patients sufferfrom severe burn injuries, with each year average of 300 deaths. Improvementsin the understanding of the prognostic factors affecting burn injuries over thepast decades have led to advances in medical and surgical treatment. However,comprehensive data on the factors affecting burn injuries in Indonesia havenot been available, yet. The aim of the study was to investigate the prognosticfactors affecting the mortality of 2nd and 3rd burn injuries patients in Dr. SardjitoGeneral Hospital, Yogyakarta. This was a cross-sectional study conducted withinthe period of 2007-2011 using secondary data from the Department of MedicalRecords. Chi-square and logistic regression analysis were used to evaluate thecorrelation between the prognostic factors and the mortality. A p value < 0.05(95% confidence interval) was considered to be significant. A significantlycorrelation between age, burn injuries percentage, arrival time, inhalation trauma,hemoglobin level, albumin level, creatinine level, hematocrit level and the patient’smortality was observed in this study (p<0.05). However, the cause of burn injuriesand leukocyte count had no correlation with the patient’s mortality (p>0.05).Furthermore, patients with albumin level < 3.5 mg/dL, burn injuries percentage>50%, inhalation trauma and hospitalized in 24 hours after the incident were at22.98, 7.65, 3.0 and 4.59 times higher risk of mortality, respectively (p<0.05).In conclusion, albumin level, burn injury percentage, inhalation trauma and time ofarrival are prognostic factors affecting the mortality of the burn injuries patients.
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12577
10.19106/JMedSci005002201809
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12577/pdf
Copyright (c) 2018 Ishandono Dachlan, Khoirul Anam
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12578
2019-11-14T07:32:11Z
bik:ART
Comparison of wound healing of skin incision on albino rat (Rattus norwegicus) by treatment of electrical stimulations
Herdiawan, Rina Puspasari
Rezano, Andri
Vitriana, .
Ruslina, Irma
Pitaloka, Pritha
Achadiyani, .
skin, wound healing, electrical stimulation, TENS, HVPC, LIDC
Wound interferes with the equilibrium of skin functions. It disrupts a barrier function of the skin as external barrier of the internal organ from physical, chemical and biological environment. The wound can be easily treated but neglected wound can lead to several complications. Accelerate wound healing will prevent complications and reduce aesthetic problem in anti-aging treatment. Previous studies showed that physical modulation as electrical stimulation could enhance wound healing processes. This study purposed to compare three different modes of electrical stimulation on wound healing such as transcutaneous electrical nerve stimulation (TENS), high voltage pulse current (HVPC) and low-intensity direct current (LIDC). This in vivo study used incisional skin biopsy of albino rat (Rattus norvegicus). Qualitative and quantitative parameters were analyzed to compare three different electrical stimulations on the wound healing response on the epidermis, dermis, inflammation, and angiogenesis phase. The highest histological score on the epidermis and dermis was found on LIDC whereas the highest histological score on the inflammation and angiogenesis phase was found on HVPC. This result of this study may provide useful information for selecting additional treatment for wound healing.
Universitas Gadjah Mada
2019-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12578
10.19106/JMedSci005102201901
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 98-105
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 98-105
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12578/pdf
Copyright (c) 2019 Rina Puspasari Herdiawan, Andri Rezano, . Vitriana, Irma Ruslina, Pritha Pitaloka, . Achadiyani
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12663
2019-05-21T07:11:46Z
bik:ART
Chronic wound mitomycin-c-induced animal models
Ariawan, Andreas
Wicaksana, Aditya
Fauzi, Aditya Rifqi
Seswandhana*, Rosadi
chronic wound; wound profile; mitomycin-c
ABSTRACTChronic wound is a problem often encountered, especially in areas that do not have adequate health facilities. Some of the factors that caused the injury are mechanical, chemical, electrical, or heat. Chronic inflammation and bacterial infections are the two major factors that affect the process of wound chronicity. Mitomycin-C (MMC) is widely used as an intravenous, oral, and topical anti-cancer drug. MMC that is applied topically to a wound can cause cross-linking and decrease or stop the process of DNA transcription so that the wound will not develop the healing phase because MMC works as an inhibitor of fibroblast and proliferation that can inhibit wound healing. This study aimed to create animal models of chronic wound using topical MMC compared to those who given exposure of NaCl without topical MMC. This study used eight female Wistar rats aged 70 to 90 days, weighed between 300 to 350 grams. Wounds were made in the hip area with a diameter of approximately two centimeters. The subjects were divided into two groups. The first group, we compressed the wounds using sterile gauze moistened with MMC 0.5 mg/ml for 5 minutes and rinsed with a saline solution as much as 10 ml6. The second group was compressed using sterile gauze moistened with saline for 5 minutes. On day 3, 5, and 15 we observed the wound profile that was consist of diameter (as an indicator of wound healing), necrosis, and the consistency. The wounds that were compressed using MMC showed brownish-black, dry, thick chronic wounds and took longer to heal compared to those with NaCl. Application of MMC topically on the wound after day 15 showed an inhibition of wound healing process. The animal models showed a slower decrease of wound diameter, fewer scar tissue formation, and development of necrotic tissue.
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12663
10.19106/JMedSci005002201803
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12663/pdf
Copyright (c) 2018 Andreas Ariawan, Aditya Wicaksana, Aditya Rifqi Fauzi, Rosadi Seswandhana*
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12781
2019-05-21T07:30:39Z
bik:ART
Effect of rich resistant starch snack on MCP- 1 promoter methylation and triglycerides levels in type 2 diabetes mellitus patients
Fadlilah, Synta Haqqul
Sunarti, .
Farmawati, Arta
Type 2 diabetes mellitus, resistant starch, DNA methylation, MCP-1, triglyceride
Type 2 diabetes mellitus (T2DM) is closely related to inflammation. One of inflammation marker in T2DM is monocyte chemoattractant protein-1 (MCP-1). Previous research suggests that MCP-1 promoter methylation correlated significantly with plasma triglycerides levels (TG) in T2DM. Some studies state that TG levels in T2DM can be controlled through consumption of diets containing resistant starch. This study aimed to investigate the effect of high resistant starch snack on MCP-1 promoter methylation and triglycerides levels in type 2 diabetes mellitus. This study was a cross-over trial. A total of 19 T2DM subjects have been selected with the criteria of fasting blood glucose levels (GDP)>126 mg/dL, aged 40-60 years, and duration of DM at least 1 year. Subject consume snack as much as 32 g/day with the resistant starch content are 4.25 g for 4 weeks. Data collection and blood retrieval was doing before and after the intervention. The analysis of MCP-1 promoter methylation was performed by methylated specific-PCR (MS-PCR) using DNA samples extracted from mononuclear cells, whereas TG levels analysis performed by the enzymatic colorimetric method (DiaSys Kit) using blood plasma. Statistic analysis was performed by Fisher Exact test for methylation data, paired t-test and unpaired t test for TG levels, and Spearman correlation test for the correlation between variabels (p<0.05). Methylation result showed that frequency of “methylated” (52.6%) and “unmethylated” (47.4%) status before and after intervention were same, so there was no significant difference (p>0.05). Plasma triglyceride levels after intervention decreased, but not significant statistically. The correlation between MCP-1 promoter methylation and plasma triglyceride levels was significant. This study concludes that the giving of rich resistant starch snacks intervention does not affect MCP-1 promoter methylation changes significantly. This intervention can lead to decrease plasma triglyceride levels subjects, but not statistically significant.
Universitas Gadjah Mada
2018-12-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12781
10.19106/JMedSci005002201813
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12781/pdf
Copyright (c) 2018 Synta Haqqul Fadlilah, . Sunarti, Arta Farmawati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12807
2019-08-08T06:04:08Z
bik:ART
The effect of hemofilter, preoperative and intraoperative methylprednisolone on complications after open heart surgery
Supomo, .
Aryandono, Teguh
Soesatyo, Marsetyawan
Sudiharto, Paulus
hemofilter – methylprednisolone – complication - open heart surgery – intraoperative
Complications after open heart surgery may threaten patient’s survival rate. Theintraoperative methylprednisolone administration alone shows controversial resultson open heart surgery complications. Similarly, the intraoperative and preoperativemethylprednisolone administration as well as the use of hemofilter in open heart surgeryis still controversial. This study aimed to evaluate the effect of hemofilter, preoperativeand intraoperative methylprednisolone administration on complications following openheart surgery. This was a Prospective Randomized Open-Blinded Evaluation (PROBE)experimental study. Ninety-five patients who had open heart surgery in Dr. SardjitoGeneral Hospital, Yogyakarta, and Integrated Cardiac Care of Dr. Cipto MangunkusumoGeneral Hospital, Jakarta within the period of December 2011 to May 2012 wereinvolved in this study. The patients were divided into two groups i.e. group A, 48 patientsreceived methylprednisolone 15mg/kg intraoperatively, methylprednisolone 5mg/kgpreoperatively, and hemofilter, while group B, 47 patients received methylprednisolone15mg/kg intraoperatively alone. From the total 95 patients, we found 26 (27.4%)patients experienced complications i.e. 19 in group B (40.4%) and 7 in group A(14.6%). The differences of the complications were statistically significant (p<0.05;OR=3.97; 95%CI=1.476-10.71). Complications risk decreased by 63.9% in the groupA compared to the group B with the hazard ratio of 3.2. In conclusion, the application ofhemofilter, preoperative and intraoperative methylprednisolone might decrease the risk ofcomplications after open heart surgery.
Universitas Gadjah Mada
2017-12-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12807
10.19106/JMedSci004904201704
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 183-190
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 183-190
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12807/pdf
Copyright (c) 2017 . Supomo, Teguh Aryandono, Marsetyawan Soesatyo, Paulus Sudiharto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/12945
2019-08-08T05:40:18Z
bik:ART
Outcomes of surgical management of intracerebral hemorrhagic stroke at a tertiary care center in Yogyakarta, Indonesia
Hartanto, Rahmat Andi
Jauhardin, Teuku
intracerebral hemorrhagic stroke – surgical treatment – conservative management – outcomes
Hemorrhagic stroke remains a significant cause of morbidity and mortality worldwide. However, the role of surgical treatment for hemorrhagic stroke remains controversial. Previous studies had proposed surgery can prevent herniation, lowering intracranial pressure (ICP) and reducing mass effect and cellular toxicity. Outcome in previous studies are conflicting. Studies concerning outcomes of surgical management of hemorrhagic stroke in Indonesia are limited. This study aimed to compare the outcome of hemorrhagic stroke treatment between surgical evacuation and conservative management in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Retrospective cohort study was conducted. Eighty spontaneous intracerebral hemorrhagic (ICH) stroke patients involved in this study during January 2014 to August 2015. Of whom 36 (45%) male and 44 (55%) female. There were 45 and 35 patients underwent surgical treatment and conservative management, respectively. Surgical treatment group survival was 74%, whereas the survival in the conservative group was 26%. There was a statistically significant difference between surgery group and conservative group (p
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/12945
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/12945/pdf
Copyright (c) 2018 Rahmat Andi Hartanto, Teuku Jauhardin
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/13595
2019-10-31T02:47:45Z
bik:ART
The effect of human saliva compared to Aloe vera on wound healing of 2nd degree burn injury in animal models
Putro, Budi Cahyono
Dachlan, Ishandono
human saliva – Aloe vera – natrium chloride – 2nd degree burn injury - model
Burn injury is one of the common causes of injury that has relatively high morbidity and mortality. Several studies using herbal and traditional medicine from different countries have been documented in burn injury management. Human saliva that contains antibacterial, antifungal, antiviral and analgesic components as well as growth factors can induce re-epithelialization process in 2nd degree burn injury. Whereas, Aloe vera that influence a physiological moist condition was proven can induce re-epithelialization process lead to faster wound healing. This study aimed to compare topical application of human saliva and A. vera on wound healing process of 2nd degree burn injury. This was an experimental study using post-test only control group design using 27 white rats (Rattus novergicus) of Sprague Dawley strain divided into 3 groups with 9 rats in each group. Group I were applied 1 mL of human saliva, Group II were applied A. vera and Group III as control were applied NaCl. Change in body weight and macroscopic clinical assessment were observed every day for 14 days, whereas histological examination was observed on day 14. The data were presented as mean ± standard error of the mean (SEM) and analyzed using one-way analysis of variance (Anova). The result showed that the wound healing process at each treatment showed different level. The human saliva application tended to show faster wound healing process of 2nd degree burn injury compare with A. vera or NaCl (p
Universitas Gadjah Mada
2019-10-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/13595
10.19106/JMedScie/005004201801
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/13595/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/13595/720
Copyright (c) 2019 Budi Cahyono Putro, Ishandono Dachlan
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/15621
2019-08-05T06:59:10Z
bik:ART
Surgical outcome of scoliosis in Marfan syndrome: a case series report
Irianto, Komang Agung
Wardana, Gestana R
scoliosis - Marfan syndrome – quality of life - questionnaire SF-36 – Cobb angle
original article
Scoliosis in marfan syndrome (MFS) manifests on 60% patients. Moreover, the scoliosisnoticeable in earlier age is more progressive, refracted, and rigid compared to idiopathicadult scoliosis. The surgical correction provides notorious higher perioperative risk,whereas conservative treatment using brace is not effective to prevent progressivityof the scoliosis. In this a case report, we reported the surgical outcome of MFS scoliaispatients with MFS who operated using posterior fusion instrumentation by mean of thequality of life SF-36 questioner. This was a retrospective case series involving five MFSscoliosis patients who underwent posterior fusion instrumentation with initial Cobb angleof 87.417.57o and initial kyphotic angle of 32.8 ± 14.52o. Clinical, radiological andquality of life of the patients based on SF-36 questionnaire were evaluated within 6-36months follow up. Post-operative showed the Cobb angle become 46.2 ± 16.3o and thekyphotic angle become 21.6 ± 9.94o. No intraoperative or post-operative complicationswere observed. After 6-36 months follow up, the Cobb angle became 45.2 ± 17.48oand the kyphotic angle became 21.6 ± 9.94o. In addition, all patients had physical andmental health scored similar to 2 years post-surgery scoliosis scoring according to SF-36 orthopedic scoring guidelines. I conclusion, the surgical outcome of posterior fusioninstrumentation in MFS scoliosis showed good correction of Cobb angle and Kyphoticangle. The quality of life of the patients based on physical and mental health questionnaireis satisfactory.
Universitas Gadjah Mada
2018-04-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/15621
10.19106/JMedSci005002201814
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/15621/pdf
Copyright (c) 2018 komang agung irianto, Gestana R Wardana
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/15937
2019-08-05T07:20:12Z
bik:ART
Prolonged Kidney Ischemia-Reperfusion Injury Associates with Inflammation, Vascular Remodelling, and Myofibroblast Formation
Arfian*, Nur
Ats-tsani, Hilma Kholida
Sayekti, Pratiwi Indah
Lakabela, Dwina Agrila
Amelia, Amelia
Febriyanto, Toni
Antonio, Hana Rutyana Putri
Wibisono, Dian Prasetyo
Sari, Dwi Cahyani Ratna
ischemia; reperfusion injury; kidney; inflammation; vascular remodelling; myofibroblast
Prolonged kidney ischemia-reperfusion injury (IRI) is the important risk factor for leading to chronic kidney disease (CKD). Persistent hypoxia and inflammation are considered as the main pathogenesis of chronic injury, followed by myofibroblast expansion and fibrosis process. Tubular injury, cell proliferation, and vasoconstriction, as acute compensatory responses, are restored in chronic phase. The aim of the study was to investigate the relation between inflammation, vascular remodeling, and myofibroblast formation as response to ischemia injury after prolonged kidney ischemia-reperfusion (I/R). Fifteen male Swiss mice aged 3-4 months were used as kidney I/R injury model after bilateral pedicle renal clamping. Rats were divided into 3 groups with five rats in each group i.e. control group (sham operation/SO), acute I/R model (IR1), and chronic I/R model (IR12). PAS staining was used for scoring tubular injury. Fibrosis was assessed using sirius red and a-SMA immunostaining for myofibroblast expansion. PCNA and CD68 immunostaining were used for identifying cell proliferation and macrophage infiltration. RT-PCR was conducted for assessing MCP-1, HIF-1a, and ppET-1 expression, which were quantified using ImageJ software. Data were analyzed using one way ANOVA and Kruskal-Wallis test with significance level of p<0.05. Significantly increase of tubular injury score (p<0.001) and PCNA positive cell (p<0.001) in IR1 group compared to SO were observed, otherwise HIF-1a of IR12 enhanced (p<0.05). Macrophage cell count (p<0.01) and MCP-1 expression (p<0.05), were significantly increase in IR1 and IR12 injury, compared to SO. Wall thickness of arteries was significantly increase (p<0.05) as well as decrease of vascular lumen area (p<0.05), followed by enhancement of ppET-1 expression (p<0.01) in IR1 group and restored significantly (p<0.05) in IR12 group. Fibrosis fraction-area and myofibroblast expansion were significantly increase gradually from IR1 to IR12 injury (p<0.01). In conclusion, prolonged kidney I/R injury induces the sustainability of hypoxia and inflammatory response, which promotes myofibroblast formation, and decrease the response of vascular remodelling.
Universitas Gadjah Mada
PUPT (Penelitian Unggulan Perguruan Tinggi)
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/15937
10.19106/JMedSci005001201801
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/15937/1
Copyright (c) 2018 Nur Arfian*, Hilma Kholida Ats-tsani, Pratiwi Indah Sayekti, Dwina Agrila Lakabela, Amelia Amelia, Toni Febriyanto, Hana Rutyana Putri Antonio, Dian Prasetyo Wibisono, Dwi Cahyani Ratna Sari
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/16647
2018-11-16T02:51:10Z
bik:ART
Sepsis risk factor in mount Merapi eruption victims with 2nd or 3rd degree of burn injury
Zega, Yamoguna
Dachlan, Ishandono
human saliva – aloe vera – natrium chloride – 2nd degree burn injury
Sepsis is one of the fatal complications of burns. It is the most common cause of deathfrom burns. Burn sepsis usually occurs after a burn injury develops into infection. Thisstudy was conducted to determine correlation between age, burn area, inhalation trauma,enteral nutrition start time, escarotomy time, and albumin level of sepsis in patientswith 2nd or 3rd degree burn injury. This was a cross sectional study during May to June2012. The subjects in this study were 39 victims of mount Merapi eruption in 2010 whosuffered 2nd or 3rd degree of burns injury. The result showed the correlation betweenwidespread burns, inhalation trauma, time of escarotomy, and albumin levels with sepsis(p < 0.05). In conclusion, the risk factor for sepsis in patients with 2nd or 3rd degree ofburns injury are the area of burns (> 50%), inhalation trauma, time of escarotomy (> 72hours), and albumin levels (<3.5g/dL).
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/16647
10.19106/JMedSci005001201810
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/16647/pdf
Copyright (c) 2018 Yamoguna Zega, Ishandono Dachlan
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/16719
2018-07-23T03:30:51Z
bik:ART
Effect of exercise on lipid peroxidation in student soccer players
Puspaningtyas, Desty Ervira
Afriani, Yuni
Mahfida, Silvi Lailatul
Kushartanti, Wara
Farmawati, Arta
soccer – exercise - O2max - lipid peroxidation – malondialdehyde
student soccer players
Training is conducted to improve physiological functions that can support improvementof cardio-respiratory function (O2max). However, intensive training can lead to oxidativestress, which can contribute to health problems. The purpose of this study was to evaluatethe effect of training on serum lipid peroxidation levels in student soccer players. Thestudy was pre-experimental study with a one-shot case design conducted in April 2014.Twelve student soccer players from UGM who chosen by purposive sampling and metthe inclusion and exclusion criteria were involved in the study. Each subject receivedtraining in the form of O2max measurements using the yo-yo intermittent recovery test.Plasma malondialdehyde (MDA) levels were measured using the thiobarbituric acidmethod 30 min after O2max measurement. Pearson correlation was used to analyzethe correlation between O2max and plasma MDA levels. The mean age of subject was19.25±1.06 years old. Subjects had normal nutritional status (body mass index 20.99± 1.65) with mean body weight of 58.13±3.76 kg and mean height of 166.2±3.40cm. The mean O2max score was 49.56±0.61 mL/kg/min. The mean plasma MDA levelwas 4.32±2.09 μmol/L. There was no significant correlation between O2max and plasmaMDA levels (p=0.7717). In conclusion, training does not negatively impact oxidativestress conditions in student soccer players.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/16719
10.19106/JMedSci005001201811
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/16719/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/16719/871
Copyright (c) 2018 Desty Ervira Puspaningtyas, Yuni Afriani, Silvi Lailatul Mahfida, Wara Kushartanti, Arta Farmawati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/16920
2019-10-31T02:47:45Z
bik:ART
Differentiation of body fat composition between skinfold caliper (SKF) and bioelectrical impedance analysis (BIA) methods among professors
Zhe Yiin, Nicole Ngo
Lubis, Leonardo
Luftimas, Dimas Erlangga
bioelectrical impedance analysis - body fat percentage – professors - skinfold caliper – body mass index
Body fat composition reflected by body fat percentage (BF%) is one of the important components in disease risk evaluation. Among the methods available to measure BF%, skinfold calipers (SKF) and bioelectrical impedance analysis (BIA) are the most commonly used. The study was conducted to evaluate the difference in body fat composition measurement between SKF and BIA methods among professors. This study analyzed secondary data from the health evaluation of Universitas Padjadjaran (UNPAD) professors. This study involved 72 professors (50 male, 22 female) after fitted into the inclusion and exclusion criteria. BF% was measured among UNPAD professors using SKF and BIA. After obtaining agreement by Bland-Altman Plot, the data were analyzed by muliple paired-t test according to gender, physical activity level and body mass index (BMI) categories. The study showed no significant difference in BF% between SKF and BIA in overall population, between gender and physical activity level (p>0.05). For BMI, the only category that showed significant difference in BF% between the 2 methods was obese I group (p=0.001). In conclusion, there is no significant difference in BF% between SKF and BIA methods according to gender, physical activity levels and BMI categories except for obese I group.
Universitas Gadjah Mada
2019-01-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/16920
10.19106/JMedScie/005004201809
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/16920/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/16920/897
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/16920/898
Copyright (c) 2019 Nicole Ngo Zhe Yiin, Leonardo Lubis, Dimas Erlangga Luftimas
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/16949
2019-05-21T07:13:11Z
bik:ART
Correlation between haemoglobin concentration and oxygen saturation (SpO2) in elderly professors
Suherlim*, Della Aprilliana
Permana, Hikmat
Lubis, Leonardo
hemoglobin - oxygen saturation – professors – elderly - immunity
The aging process is recognized by the decreases of the body functions which is caused by molecular and cellular damages. The population which is mostly affected by this aging process is elderly. In elderly, it is most likely that tissue oxigenation decreases due to the reduction of haemoglobin level and oxygen saturation (SpO2).This study aimed to evaluate the correlation between the hemoglobin concentration and SpO2 in the elderly professors in Universitas Padjadjaran (UNPAD), Bandung. This was cross sectional study using secondary data from medical records of the elderly professors. One hundred and eight data of the professors (84 males and 24 females) who met the inclusion and exclusion criteria were used in this study.Spearman’s Rank correlation test was used to analyze the data of total subjects and male professors group, while Pearson correlation test was used to analyze the data of female professors group. Correlation test between hemoglobin concentration and SpO2 resulted in an insignificant results in male professors (r = 0.028; p = 0.801), female professors (r = 0.132; p = 0.538), and total subjects (r = 0.036; p = 0.712). In conclusion, there is no correlation between hemoglobin concentration and SpO2 in the elderly professors of UNPAD, Bandung.
Universitas Gadjah Mada
Leonardo Lubis, Universitas Padjajaran, Department of Anatomy, Physiology, and Cell Biology
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/16949
10.19106/JMedSci005002201804
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/16949/pdf
Copyright (c) 2018 Della Aprilliana Suherlim*, Hikmat Permana, Leonardo Lubis
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17066
2019-08-05T07:20:12Z
bik:ART
Correlation between CD4 cell counts with mucocutaneous manifestations: study of HIV patients in Dr. Sardjito General Hospital, Yogyakarta
Pudjiati, Satiti Retno
Dewi, Nadia Akita
Palupi, Sekar Sari Arum
CD4 cell count; mucocutaneous manifestations; HIV; opportunistic infection; fungal infection
Mucocutaneous disorders often seen in HIV patients with varying morbidity. The HIVprogression is characterized by the declining of CD4 cell counts and emergence ofmucocutaneous manifestations. The aim of the study was to evaluate the relationshipbetween CD4 cell counts with mucocutaneous manifestations in HIV patients. This wasa cross-sectional study based on medical records at Dr. Sardjito General Hospital duringthe period January 2011-December 2015. Data of patient’s age, sex, risk factors oftransmission, most mucocutaneous manifestations and CD4 cell count were gathered. Thecorrelation between CD4 cell counts with muscocutaneous manifestations were analyzedusing chi-square test. A total 928 patients were involved in the study. More than half ofthe patients were male (65.4%) and mostly, the patients aged 20-29 years (38.69%).The main risk factors for HIV transmission were unsafe sex (75%). The highest CD4 cellcounts was 1094 cells/mm3 and the lowest was 1 cell/mm3. We found 306 cases ofmucocutaneous manifestations. The most mucocutaneous manifestations was a fungalinfection (40.4%) with the highest infection type was oral candidiasis(33.8%); then noninfection(28%) with the highest type was drug eruption(35.9%); and tumors(0.5%) thatwas only Kaposi sarcoma cases. We also found sexually transmitted infections (STIs)(18.85%) with the highest cases was condyloma acuminata (49.3%). Statistical analysisshowed a significantly relationship between CD4 cell counts with a fungal infection(p <0.0001; OR= 3.8; 95% CI: 2.29 - 6.30), viral infection (p =0.0031; OR= 0.4;95% CI: 0.24-0.74) and parasitic infection (p=0.043; OR= 0.2; 95% CI: 0.06-0.61).In conclusion, alteration in CD4 cell counts affects opportunistic infections occurencein HIV patients. Lower CD4 cell counts (<200 cells/mm3) increases the risk of fungalinfection as much as 3.8 times. Higher CD4 cell counts (>200 cells/mm3) increases therisk of viral infection by about 2.5 times and parasitic infections as much as 5 times.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17066
10.19106/JMedSci005001201805
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17066/pdf
Copyright (c) 2018 Satiti Retno Pudjiati, Nadia Akita Dewi, Sekar Sari Arum Palupi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17118
2019-05-21T07:10:18Z
bik:ART
The effects of ethanolic extract of Phaleria macrocarpa (Scheff.) Boerl leaf on macrophage phagocytic activity in diabetic rat model
Lestari, Ira Cinta
Ghufron, Muhammad
Herwiyanti, Sri
Sumiwi, Yustina Andwi Ari
diabetes mellitus; peritoneal macrophage; phagocytosis; M1 macrophage; M2 macrophage
Diabetic patients suffer inflammation and immune deficiency as a consequence of the decrease in macrophage phagocytic activity, thus making them vulnerable to infection. The ability of Ethanolic Extract of Phaleria macrocarpa Leaf (EEPML) to increase macrophage phagocytic activity has also a potential in the diabetic case. EEPML also has anti-inflammatory effect. In this study the EEPML potential to increase peritoneal macrophage phagocytic activity and change M1 and M2 macrophage percentage in diabetic rat model is investigated. This was a quasi experimental study with post test only control group design. Fourty five male Sprague Dawley rats within the age of 8 weeks were classified into normal control group, diabetic control group with solvent, diabetic with 7mg/200g, 14mg/200g, and 28mg/200g of EEPML peroral administration, once a day. The diabetic rat model was made with streptozotocin and nicotinamide injection. The rats were terminated in 3rd, 14th and 25th day of extract administration. Peritoneal fluid was isolated then cultured for macrophage phagocytic activity assay with latex beads. M1 and M2 macrophage percentage was analyzed using flow cytometry with anti CD40 and CD206 antibody. Result of statistical analysis show that active macrophage and phagocytic index mean of EEPML rat groups on day 3, 14 and 25 was significantly higher than the control group. The mean of M1 macrophage percentage of EEPML rat groups was significantly higher than control on day 3 and 14, and lower on day 25, while mean of M2 macrophage percentage didn’t show any significant difference within groups. Conclusion of this study is administration of EEPML increases peritoneal macrophage phagocytic activity on day 3, 14 and 25. This is also increases M1 macrophage percentage on day 14, decrease M1 macrophage percentage on day 25, and doesn’t change peritoneal M2 macrophage percentage in diabetic rat model.
Universitas Gadjah Mada
2018-06-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17118
10.19106/JMedSci005002201802
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17118/pdf
Copyright (c) 2018 Ira Cinta Lestari, Muhammad Ghufron, Sri Herwiyanti, Yustina Andwi Ari Sumiwi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17194
2019-08-08T05:40:18Z
bik:ART
The expression of COX-2 and iNOS in ethanol and aspirin induced gastric ulcer rat models
usman, sherly
Paramita, Dewi Kartikawati
Sumiwi, Yustina Andwi Ari
gastric mucosal damage - gastric ulcer - aspirin - ethanol - COX-2 - iNOS
medical sciences
Aspirin or ethanol induced gastric ulcer rat models are the most frequently used in studies.Aspirin and ethanol induced gastric ulcers through different pathways involving COX-2 andiNOS. The aim of this study was to examine the expression of COX-2 and iNOS in gastriculcer rat model induced by ethanol and aspirin. Twenty-one Sprague Dawley rats weredivided into 7 groups i.e. control group (CA), ethanol 1st day (ED1), ethanol 3rd day (ED3),ethanol 5th day (ED5), aspirin 4th day (AD4), aspirin 6th day (AD6), and aspirin 8th day (AD8).Oral administration of aspirin was at 200mg/kgBW and the 100% ethanol at 1mL/200gBW.Macroscopic and microscopic observations were done to examine the gastric mucosaldamage, COX-2 and iNOS expressions. Severe gastric ulcers were observed in ED1and AD4 groups and mild gastric mucosal damage was observed in ED3, ED5, AD6 andAD8 groups. Microscopically, light erosion was shown by the CA and AD8 groups. Erosionwas also shown by ED3, ED5, and AD6 groups. The most severe damage with ulcers andheavier bleeding were shown by the ED1 and AD4 groups. Weak COX-2 expression wasfound in the CA, while the highest COX-2 expression was found in the ED1. The iNOSexpression in the ethanol groups was still increasing until the 5th day (ED5). In the aspiringroups, it reached the peak on the 3rd day (AD6), and already declined on the 5th day (AD8).In conclusion, the damage process of ethanol induced gastric ulcer occurred faster thanthat by aspirin. The highest COX-2 expression in the ethanol and aspirin groups wereshown at the onset begin. iNOS expression in ethanol induced ulcer groups still increaseduntil the 5th day, while in the aspirin induced ulcer groups already declined in the 5th day.
Universitas Gadjah Mada
2019-02-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17194
10.19106/JMedScie/005003201807
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17194/pdf
Copyright (c) 2019 sherly usman, Dewi Kartikawati Paramita, Yustina Andwi Ari Sumiwi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17575
2019-08-08T05:40:18Z
bik:ART
Profile of traumatic brain injury (TBI) in relation with maxillofacial and thoracic injury Dr. Hasan Sadikin General Hospital, Bandung
Pathmanathan, Padmini Laxmi
Alpharian, Gibran Tristan
Sutiono, Agung Budi
traumatic brain injury -maxillofacial - thoracic injury – accident – Glasgow Coma Scale
Traumatic brain injury (TBI) has a relation with concomitant injuries, which are mostlymaxillofacial and thoracic injury. This study aimed to know which injury was common inTBI patients and the difference in the severity of TBI when patients were associated withone or both types of injuries. This was a descriptive retrospective study. The data used wasmedical records from Department of Neurosurgery, Dr. Hasan Sadikin General Hospital,Bandung, Indonesia from the period of August 2015 to July 2016. Total sampling methodwas used in this study. The variables were patients with TBI, maxillofacial injury, thoracicinjury, accident related mechanism and non-accident related mechanism and the GlasgowComa Score (GCS). The total cases for this study were 47 patients. The highest case wasmales with 37 cases and 10 for females. Accident related trauma had 23 cases whereasnon accident related trauma had 24 cases. The total cases of maxillofacial injury were 32,thoracic were 6 cases whereby for both injuries were 9 cases. Patients with mild TBI were28 cases, moderate TBI were 13 cases, and severe TBI had 6 cases in total. The rate ofTBI was higher in single injury which was the maxillofacial injury. However, the thoracicand both injuries combined had higher severity of TBI compared to maxillofacial injury.
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17575
10.19106/JMedScie/005003201808
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17575/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/17575/1021
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/17575/1023
Copyright (c) 2018 Padmini Laxmi Pathmanathan, Gibran Tristan Alpharian, Agung Budi Sutiono
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17610
2019-03-11T04:22:12Z
bik:ART
Relationship Between Pfmdr1 Gene Polymorphisms with Therapeutic Respons of Artesunate-Amodiaquine in Uncomplicated Falciparum Malaria Patients in Puskesmas Hanura, Pesawaran Regency, Lampung
Carolia, Novita
Mustofa, .
Kristin, Erna
ABSTRACTBackground: The failure of artesunate-amodiaquine therapy in chloroquine resistant patients have been reported in several areas in Indonesia. One of the unexpected resistance mechanisms is associated with pfmdr1 gene polymorphisms. This study determine the frequency of pfmdr-1 polymorphisms and examine the relationship of pfmdr1 gene polymorphism with therapeutic responses to artesunate-amodiaquine therapy in uncomplicated falciparum malaria patients in Puskesmas Hanura, Pesawaran Regency, Lampung Methods: This study was conducted in accordance with the WHO protocol for anti-malarial drug efficacy test in uncomplicated falciparum malaria. Combination therapy used artesunate-amodiaquine and primaquine. Therapeutical response and Parasite Clearance Time was observed during 28 days of observation. Diagnosis polymorphism by PCR-RFLP technique used the patient's blood (EDTA and filter paper) were taken a tH0.Results: There were 63(85.1%) patients of Adequate Clinical and Parasitological Response, Early Treatment Failure were 5 (6.8%) people, Late Clinical And Parasitological Failure 2 (2.7 %) people, and Late Parasitological Failure 4 (5.4%) people. Seven (13.5%) patients were found with N86Y pfmdr1 gene polymorphism with mixed type (mutant type and wild-type) in which 1 (9.1%) people had failed therapy and 6 (14.6%) people were cured. There was no association between pfmdr1 gene polymorphism with artesunate-amodiaquine failed therapy (RR: 0.64, 95% CI0.97-4.27, p: 1.000). Parasite Clearance Time on pfmdr1 polymorphism group was 2.14 ± 1.21 days and 1.79 ± 1.06 days in group without pfmdr1 polymorphisms. There was no significant difference between both groups (p =0.434).Conclusions:The frequency of pfmdr1 N86Y polymorphism in Puskesmas Hanura, Pesawaran Regency, Lampung was 13,5%. There was no significant difference between the rate of treatment failure patients with pfmdr1 N86Y polimorphism compared with patients without pfmdr1 N86Y polymorphism. There was no significant difference between Parasite Clearance Time patients with pfmdr1 N86Y polymorphism compared with patients without pfmdr1 N86Y polymorphism.Keywords: falciparum malaria, artesunat-amodiakuin, polymorphism, pfmdr1
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://jurnal.ugm.ac.id/bik/article/view/17610
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
en
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17672
2019-08-05T07:20:12Z
bik:ART
The influence of acetylation status of tuberculosis patients on the isoniazid serum concentrations and sputum conversion after intensive phase therapy
Anggraini, Dwi Indria
Kristin, Erna
Dwiprahasto, iwan
acetylation status; isoniazid level; success of therapy; conversion sputum; intensive phase treatment; tuberculosis
Isoniazid (INH), one of the major antituberculosis drugs, is metabolized by acetylation. Previously study proved the significant differences of serum INH concentration between subject with fast and slow acetylation status. However, the correlation of acetylation status with treatment outcome after fixed-dose combination antituberculosis therapy (FDC-ATT) was not explained. The aim of this study was to evaluate the influence of acetylation status on the treatment outcome and the serum INH concentrations in the adult tuberculosis patients underwent FDC-ATT. A cross sectional study was carried out on 31 tuberculosis patients. Acetylation status was measured by spectrophotometer and serum INH concentration was measured by high performance liquid chromatography (HPLC). Sputum conversion assay was conducted by Ziehl Nelsen method. t-Test, chi square, Mann-Whitney, and Fisherman were used to analyze the data. The proportion of the fast acetylator was 61.3%, whereas the slow acetylator was 38.7%. The proportion of success and failure sputum conversion were 83.9% and 16.1%, respectively. The mean serum INH concentration in the fast acetylator groups (1.52 ± 0.15 μg/mL) was significantly lower than that in the slow acetylator groups (3.84 ± 0.35 μg/mL). The failure conversion risk of the fast acetylator group was about two folds higher than the slow acetylator group, although it was not significantly different (RR=2.53; 95% CI=0.32-20.00; p>0.05). Moreover, the mean serum INH concentration in success (2.46 ± 0.31 μg/mL) and failure (1.89 ± 0.20 μg/mL) sputum conversion was not significantly different (p>0.05). In conclusion, the acetylation status does not influence the sputum conversion in adult tuberculosis patients after FDC-ATT although the serum INH concentration on slow acetylation status is higher than that fast acetylation status.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17672
10.19106/JMedSci005001201807
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17672/pdf
Copyright (c) 2018 Dwi Indria Anggraini, Erna Kristin, iwan Dwiprahasto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17683
2019-05-20T04:15:52Z
bik:ART
Ethanolic extract of the Centella asiatica (L.) Urb. leaf decreases cerebellar brain-derived neurotrophic factor (BDNF) levels in rats after chronic stress
Sari, Dwi Cahyani Ratna
Juananda, Desby
Ar-Rochmah, Mawaddah
Romi, Muhammad Mansyur
Arfian, Nur
BDNF - Centella asiatica (L.) Urb. - cerebellum - chronic stress - prevention
Chronic stress produces glucocorticoid-induced neurotoxicity that may lead to alterations of the brain-derived neurotrophic factor (BDNF) concentration in the brain. Cerebellum is known to be severely affected by glucocorticoids-associated oxidative damage. Centella asiatica (L.) Urb. may protect neurons from oxidative damage. This study aimed to investigate the effect of ethanolic extract of C. asiatica (L.) Urb. leaf on the rat cerebellar BDNF levels following stress. Twenty young-adult male Sprague Dawley rats were randomly assigned into four experimental groups. The stress control group received aquadest, and the other groups were treated with different doses of the C. asiatica (L.) Urb. extract i.e 150 (CeA150), 300 (CeA300) and 600 (CeA600) mg/kg body weight/day orally, respectively and followed by chronic footshock stress for 28 days. Upon completion of the experimental period, all animals were sacrificed and the cerebellar was isolated. The BDNF levels from the cerebellar tissue lysate was measured using ELISA. The mean BDNF levels of the cerebellar tissue in the stress control, CeA150, CeA300 and CeA600 groups were 1217.10±301.40; 771.46±241.45; 757.05±268.29; and 627.00±246.02 pg/mL, respectively. Post-hoc analysis showed a significant difference between the control and treatment groups (p< 0.05). In conclusion, the ethanolic extracts of the C. asiatica (L.) Urb. leaf decrease the cerebellar BDNF levels in rats after chronic stress.
Universitas Gadjah Mada
2018-04-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17683
10.19106/JMedSci005002201801
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17683/pdf
Copyright (c) 2018 Dwi Cahyani Ratna Sari, Desby Juananda, Mawaddah Ar-Rochmah, Muhammad Mansyur Romi, Nur Arfian
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17777
2019-08-08T06:04:08Z
bik:ART
Mechanism of cytotoxic activity of chalcone derivatives against K562 leukemia cell lines
Novilla, Arina
Mustofa, .
Astuti, Indwiani
Jumina, .
Suwito, Hery
anticancer - chalcone derivatives – leukemia – K562 cell line - PI3K/Akt signaling
Two chalcone derivatives i.e. (E)-1-(4-aminophenyl)-3-(2,3dimethoxyphenyl)-prop-2-en-1-one (Compound-1), and (E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one) (Compound-2),has been proven to have potential cytotoxic activity. The aim of this study was toevaluate the effect of these compounds on PI3K/Akt signalling pathway in K562 celllines. After incubation with the tested compounds, AKT, caspase-3, STAT3 and cyclinD1 concentrations were measured using ELISA. Furthermore, cell cycle was analysedusing flowcytometry. Imatinib and isotretinoin were used as positive control, whereascell culture without treatment was used as negative control. The AKT concentration aftertreatment with Compound-1 and -2 was significantly lower than that control, imatiniband isotretinoin (p<0.05). The apoptotic indices after treatment with Compound-1 and-2 were significantly higher than control, however they were lower than imatinib andisotretinoin (p<0.05). The caspase-3 concentration after treatment with Compound-1 at5 and 10 μg/mL and Compound-2 at 10 μg/mL was significantly higher than that controland imatinib, however it was lower than isotretinoin (p<0.05). The STAT3 concentrationafter treatment with Compound-1 and -2 was significantly lower than that control andisotretinoin at 50 μg/mL (p<0.05) and similar with imatinib (p>0.05). The cyclin D1concentration after treatment with Compound-1 and -2 was significantly lower than thatcontrol, imatinib and isotretinoin (p<0.05). In addition, Compound-1 and -2 arrested G0/G1 and G2/M phase in K562 cell lines, with comparable results to imatinib and isotretinoin.In conclusion, the mechanism of cytotoxic activity of Compound-1 and -2 are through thePI3K/Akt signalling pathway inhibition, apoptosis induction by upregulation of apoptoticmarkers, and inhibition of cell cycle progression by regulating cell cycle-related factors.
Universitas Gadjah Mada
2017-12-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17777
10.19106/JMedSci004904201701
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 153-164
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 153-164
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17777/pdf_1
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/17777/1061
Copyright (c) 2017 Arina Novilla, . Mustofa, Indwiani Astuti, . Jumina, Hery Suwito
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/17835
2020-06-01T06:13:40Z
bik:ART
Sinonasal or nasopharyngeal undifferentiated Carcinoma?: diagnostic pitfall and the role of Epstein-Barrvirus (EBV) and human papillomavirus(HPV) examination
Widayati, Wahyu Tri
Dwianingsih, Ery Kus
Ardianto, Bustanul
Heriyanto, Didik Setyo
Indrasari, Sagung Rai
Herdini, Camelia
Irianiwati, .
undifferentiated carcinoma; sinonasal carcinoma; nasopharyngeal carcinoma; Epstein-Barr virus; human papilloma virus
Undifferentiated carcinoma of the head and neck is frequently observed in nasopharynx, however it may also occur in oropharynx, salivary gland and sinonasal. Overlapping lesions in those regionscreate difficulty in determining the origin of the tumor. Thus, it causes diagnostic pitfall not only for pathologists, but also for clinicians. A 40 yearold man, presented with nasal obstruction, epistaxis, diplopia, and headache for a yearand showed nasal cavitysinistra and nasopharynx masses on CT-scan. Lymph node enlargement was not detected. First biopsywas performed and histopathologically diagnosed as nasopharyngeal undifferentiated carcinoma(NPC), extended into nasal cavity. Chemo-radiation protocol for NPC was conducted, and showing uncomplete response. Second biopsy was done, and reviewed with the first biopsy result. Thetumourwas arranged insolid, syncytial and trabecular pattern, with vesicular nuclei, prominent nucleoli, and lack of lymphoplasmacytic infiltrat. Immunohistochemistry (IHC) analysis of p16, EBNA1 and LMP1 were negative. PCR analysis of HPV-18 was positive, while EBV detection showed negative result. General association of EBV with NPC suggests that the presence of latent EBV infection can serve as a positive marker for NPC. Therefore, in this case, the EBV negativity and strong HPV association led to diagnosis of SNUC. The distinction of sinonasal undifferentiated carcinoma (SNUC) or from NPC was important for appropriate management and therapy.
Universitas Gadjah Mada
2020-03-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/17835
10.19106/JMedSci005202202008
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 2 (2020)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 2 (2020)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/17835/pdf
Copyright (c) 2020 Wahyu Tri Widayati, Ery Kus Dwianingsih, Bustanul Ardianto, Didik Setyo Heriyanto, Sagung Rai Indrasari, Camelia Herdini, . Irianiwati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18083
2019-08-08T05:40:18Z
bik:ART
The effects of furosemide on kidney damage in acute kidney injury rat models
Afifah, Afifah
Ngatidjan, .
Arfian, Nur
acute kidney injury - ischemic-reperfusion – furosemide – creatinine – kidney tubular injury
The most frequent cause of acute kidney injury (AKI) is ischemia reperfusion injuriesthat causes inflammation. Furosemide is still used in AKI’s therapy. The advantages anddisadvantages of furosemide in AKI remain controversial. The aim of the study was toinvestigate the effect of furosemide on kidney damage in AKI rat models. Twenty-fivemale (2-3 months old) Sprague-Dawley rats were divided into 5 groups; sham operation(SO, n=5), ischemic-reperfusion (IR, n=5), IR+furosemide 3.6 mg/kgBW (IR+F1,n=5), IR+furosemide 7.2 mg/kgBW (IR+F2, n=5), and IR+furosemide 14.4 mg/kgBW(IR+F3, n=5). Abdominal surgery was performed under ketamine anesthesia to produceischemic reperfusion (IR) by mean of renal artery clamping for 45 min. Urine output,serum creatinine level, tubular injury score, and TLR4 gene expression were examinedto investigate kidney damage. Periodic acid-schiff (PAS) staining was measured toexamine kidney tubular injury. Data were analyzed using One-Way ANOVA and Kruskal-Wallis test with significance level of p<0.05. AKI rat models which were given 3.6 and7.2 mg/kgBW of furosemide (0.014±0.001 mL/min; and 0.012±0.007) showed higher(p>0.05) creatinine clearance compared to IR (0.009±0.003) while administration of 14.4mg/kgBW furosemide (0.009±0.004) denoted equal creatinine clearance to IR (p>0,05).Kidney tubular injury score of 3.6 mg/kgBW furosemide (2.89±0.13) was lower (p>0.05)than IR (3.26±0.19) whereas 7.2 mg/kgBW and 14.4 mg/kgBW furosemide (3.55±0.26;3.83±0.19) were higher (p<0.05) than IR. Administration of 3.6 mg/kgBW furosemide(0.99±0.08) indicated lower (p<0.05) TLR4 gene expression than IR (1.20±0.08) whilst7.2 mg/kgBW furosemide (1.23±0.13) was not-significantly higher (p>0.05) and 14.4 mg/kgBW furosemide (1.63±0.12) was significantly higher (p<0.05) than IR. In conclusion,administration of 3.6 mg/kgBW furosemide reduces kidney damage in AKI rat modelswhile higher dosages (7.2 mg/kgBW and 14.4 mg/kgBW) increase kidney damage.
Universitas Gadjah Mada
2018-11-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18083
10.19106/JMedScie/005003201801
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18083/pdf
Copyright (c) 2018 Afifah Afifah, . Ngatidjan, Nur Arfian
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18096
2019-11-14T07:32:11Z
bik:ART
An evaluation study of enzyme-linked immunosorbent assay (ELISA) using recombinant GRA1 protein for detection of igg antibodies againts Toxoplasma gondii infections
Muflikhah, Nina Difla
Artama, Wayan Tunas
Toxoplasmosis, recombinant protein, ELISA, diagnostic tools
Reliable laboratory testing is important to detect Toxoplasma gondii infection and focuses on improving the low cost and easy to use the diagnostic instrument. Enzyme-linked immunosorbent assay (ELISA) method can be used to determine a large number of samples within a short period of time which based on antibody or antigen detection. We tested the sensitivity and specificity of GRA1 protein of as antigen using the ELISA method to toxoplasmosis diagnosis and compared it with commercial ELISA kit. Seventy sera samples were collected and tested using indirect ELISA, commercial ELISA kit and GRA1 protein-coated as antigen. The results showed 48 and 51 samples had positive IgG antibody using ELISA-GRA1 and commercial ELISA kit, respectively. The GRA1 sensitivity and specificity on ELISA were 100% and 86.36%, respectively. Whereas positive predictive value (PPV) was 94.11%. This result indicated that the recombinant GRA1 protein is a highly immunogenic protein in human toxoplasmosis and marker for toxoplasmosis screening.
Universitas Gadjah Mada
2019-07-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18096
10.19106/JMedSci005102201904
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 128-133
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 128-133
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18096/pdf
Copyright (c) 2019 Nina Difla Muflikhah, Wayan Tunas Artama
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18860
2018-06-19T00:09:34Z
bik:ART
Effect of Syzigium cumini (pulp) extract on malondyaldehyde and blood pressure in chronic restraint stress rat
Suryajayanti, Mega Febia
Dewi, Anggi Laksmita
Nurrahma, Bira Arumndari
Putri, Ayu Dwi Silvia
Khairia, Zunamilla
Farmawati, Arta
ABSTRACTIntroduction. Chronic stress disturbs the equilibrium of oxidant-antioxidant redox in the human body which accelerates cellular aging. This condition promotes earlier onset of age-related diseases. Human body needs exogenous antioxidant to fight stress. Syzigium cumini has high antioxidant activity because it’s rich in anthocyanin. It has potential to become natural antioxidant source thus it needs to be developed.Aim. This study aims to investigate the effect of Syzigium cumini (Pulp) extract on the stress biomarkers which are Malondialdehyde and blood pressure in rat induced by restraint stress.Method. Chronic stress phase is conducted with male Wistar rats (n=20) which were divided into 4 groups (normal control, negative control, and two treatment groups with the ethanol extract of Syzygium cumini (Pulp) at 20 mg/200 gram and 40 mg/200 gram body weight). Restraint stress was carried out by placing the animal in narrow tube for 30 minutes daily (7 days). Blood pressure was evaluated before and after the treatment while Malondialdehyde was evaluated after the treatment. The One-way ANOVA was used to analyze the parameters.Results. Based on chronic stress phase, treatment groups show significant result in preventing the increase in blood pressure (P < 0,001). The increased levels of Malondialdehyde were prevented significantly in all treatment groups (P < 0,001)Conclusion. In chronic stress phase, Syzygium cumini (Pulp) extract can become an antihypertensive agent. Syzygium cumini (Pulp) extract shows an effect in decreasing lipid peroxidation products. This result shows that the Syzygium cumini (Pulp) extract has potent antioxidant function.Keywords. Syzigium cumini, restraint stress, malondialdehyde, MDA, blood pressure
Universitas Gadjah Mada
2017-03-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18860
10.19106/JMedSci004903201703
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18860/pdf
Copyright (c) 2017 Mega Febia Suryajayanti, Anggi Laksmita Dewi, Bira Arumndari Nurrahma, Ayu Dwi Silvia Putri, Zunamilla Khairia, Arta Farmawati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18863
2019-08-08T06:04:08Z
bik:ART
R-Peaks Detection Method for Classifying Arrhythmia Disorder
Nugraha, Anggit Ferdita
Pramudita, Brahmantya Aji
Setiawan, Noor Akhmad
Nugroho, Hanung Adi
electrocardiography - R-peaks detection - QRS complex - arrhythmia disorder - Pan-Tompkins method
Electrocardiography (ECG) is a non-invasive technique that is used to diagnose heartabnormalities. ECG records all heart activities and represent them using bio electricsignals. Arrhythmia is one of the cardiac disorder that can be detected using ECG.Arrhythmia need to be detected early because of an early symptom of heart diseaseas deadly as coronary heart disease and heart failure. Arrhythmia described using thedifference between the R-peaks based on QRS complex. Therefore, R-peaks detection willbe an important factor that can be used to classify arrhythmia disease. One of the widelyused methods to detect R-peaks is Pan-Tompkins method. Pan-Tompkins method used athreshold value approach to get all location of R-peaks point from the ECG signals. Thisstudy proposed a development based on Pan-Tompkins method by change the thresholdvalue using normalize technique and moving windows approach to get all location ofR-peaks point from the ECG signals. This study uses MIT-BIH arrhythmia dataset. Thismethod can show the R-peaks detection with 99.83% sensitivity and 0.40% total errorrate detection. Hence, this method has potential to be used for classifying arrhythmiadisorder based on the R-peaks point.
Universitas Gadjah Mada
2017-12-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18863
10.19106/JMedSci004904201705
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 191-199
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 191-199
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18863/pdf
Copyright (c) 2017 Anggit Ferdita Nugraha, Brahmantya Aji Pramudita, Noor Akhmad Setiawan, Hanung Adi Nugroho
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18869
2019-11-26T06:35:56Z
bik:ART
The effect of long-term high-fat diet in ovariectomized Wistar rat (Rattus norvegicus)study on lipid profile, endothelial nitric oxide synthase(eNOS) dan endhotelin-1 (ET-1) serum
Sudarsono, Tantri Analisawati
Agustiningsih, Denny
Sunarti, S
high - fat diet - ovacriectomy - lipid profile - endothelial nitric oxide synthase (eNOS) -endothelin-1 (ET-1)
Accumulation of cholesterol in the blood will cause stiffness in arteries and trigger the formation of atherosclerotic lesions. Estrogen has a role as an antioxidant that can prevent the low density lipoprotein(LDL) oxidation. In menopause with high-fat diet, the decrease of estrogen levels will trigger cholesterol accumulation in the blood lead to endothelial dysfunction mediated by endotelin-1 (ET-1) and nitric oxide synthase (eNOS). This study aimed to investigate the effect of long-term high-fat diet on the lipid profile, serum eNOS and ET-1levels on ovariectomized rat. It was experimental using 28 female Wistar rat divided into 4 groups. Group 1 was ovariectomized mice and given a standard diet (OVX-SD), Group 2 was ovariectomized mice and given a high-fat diet (OVX-HFD), Group 3 was not ovariectomized mice and given a standard diet(SHAM-SD) group, and Group 4 was not ovariectomized mice and given a high-fat diet (SHAM-HFD).Lipid profile of blood samples was measured pre- and post-treatment, whereas serum eNOS and ET-1 levels were measured post-treatment using ELISA method. No significantly difference of lipid profileon OVX-HFD group compared to that OVX-SD was observed. The serum eNOSlevel on OVX-HFD(702.11±68.73 pg/mL) was significantly lower than that OVX-SD (857.18±118.08 pg/mL) (p<0.05). However, there was no significantly different of serum ET-1 levelbetween OVX-HFD group (299.14±146.61 pg/mL) compared to that OVX-SD (194.25±102.96 pg/mL) (p>0.05). In conclusion, the serum eNOS levelon ovariectomized rat with long-term high-fat diet is lower than that on ovariectomized rat with standard diet.
Universitas Gadjah Mada
2019-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18869
10.19106/JMedSci005103201902
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 195-202
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 195-202
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18869/pdf
Copyright (c) 2019 Tantri Analisawati Sudarsono, Denny Agustiningsih, S Sunarti
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18877
2019-08-08T05:40:18Z
bik:ART
Comparison of corneal endothelial cell count and intraocular pressure in pure-dispersive and dispersive-cohesive viscoelastic protection in phacoemulsification surgery
Nugroho, Agung
Yudono, R Haryo
phacoemulsification - corneal endothelial cell - intraocular pressure – viscoelastic – pure-dispersive - dispersive-cohesive
There are so many aspects should be regarded when use viscoelastic device during phacoemulsification surgery. The advantages and disadvantages of pure-dispersive viscoelastic and dispersive-cohesive viscoelastic always require more our attention to use it conveniently. The purpose of the study was to compare between pure-dispersive viscoelastic versus dispersive-cohesive viscoelastic in phacoemulsification surgery in that of corneal endothelial cell count and intraocular pressure (IOP) change. This was a cross-sectional study involving 41 eligible patients who underwent phacoemulsification surgery by single operator. Data including characteristics of cataract patients, corneal endothelial cell count and IOP were taken before and after surgery. Data of characteristics of cataract patients were reported descriptively and compared using Anova and t-test. The mean change in corneal endothelial cell count on pure-dispersive viscoelastic group (71.99±71.20 cells/mm²) was lower than that on the dispersive-cohesive viscoelastic group (117.62±78.29 cells/mm²). However, it was not significantly different. The mean change in IOP on pure-dispersive viscoelastic group (0.75±1.626 mmHg) was significantly lower than that on dispersive-cohesive viscoelastic group (1.90±0.995 mmHg) (p=0.000). In conclusion, the increase of IOP in dispersive-cohesive viscoelastic group is higher than that on pure-dispersive viscoelastic group. However, there is no significant difference of the mean change in corneal endothelial cell on the both groups.
Universitas Gadjah Mada
2019-01-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18877
10.19106/JMedScie/0050032018013
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18877/pdf
Copyright (c) 2019 Agung Nugroho, R Haryo Yudono
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18950
2018-07-23T03:30:51Z
bik:ART
Cinnamomum burmannii improves insulin serum level in the normal obese subjects : preliminary study
Hendarto, Hari
Sari, Flori R
Adhyanto, Chris
Cinnamomum burmannii – obesity – insulin - body mass index - lipid profile
Obesity is characterized with excessive accumulation of the body fat which occurs whenthe energy intake exceeds the expenditure. It is routinely associated with insulin resistanceand hyperinsulinemia. Additionally, suppressing insulin level protects female mice fromweight gaining. Cinnamon [Cinnamomum burmannii (Ness) Bl. Cortex] suppresseshyperinsulinemia condition in the type 2 diabetic rat suggesting the possible beneficial itsrole in the obesity. We aimed to investigate the effect of Cinnamon extract in the normalobese subjects. In this preliminary cross-over clinical trial, 24 normal obese subjectswere recruited and divided randomly into two groups i.e. treatment and placebo. Twograms of the cinnamon extract were given twice daily for 56 days in the treatment group.Normal obese subjects given placebo were allocated as the placebo group. After thetreatment, each of the group ran a one month run-in period, then the groups were crossoveredfor the next 56 days. Body mass index (BMI), insulin serum level, cholesterol andtriglyceride plasma levels were measured at the beginning and at the end of the study.No diet restriction nor exercise intervention was given during the study. At the end of thestudy, BMI in the treatment group (58%) were slightly reduced when compared to theplacebo group (33%), however, it was not significantly different (p>0.05). Moreover,significantly reduction in the insulin serum level was observed in 63% subject in thetreatment group compared to 33% subject in the placebo group (p < 0.05). Additionally,there were no significant differences of cholesterol and triglyceride plasma level observedin the both group. In conclusion, cinnamon extract may give beneficial role in the normalobese subjects by suppressing the serum insulin level. Further studies are required toelucidate the specific role of cinnamon in preventing weight gain.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18950
10.19106/JMedSci005001201808
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18950/pdf
Copyright (c) 2018 Hari Hendarto, Flori R Sari, Chris Adhyanto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18954
2019-08-08T05:40:18Z
bik:ART
Accuracy of albumin creatinine ratio in comparison with albumine excretion rate for diagnosis diabetic nephropathy in type 2 diabetes mellitus
Fatrinawati, .
Windarwati, .
Sianipar, Osman
diabetic nephropathy - albumin creatinine ratio (ACR) - albumin excretion rate (AER) – sensitivity - diagnostic test
Diabetic nephropathy (DN) is one of complications in diabetic patients manifested bymicroalbuminuria with minimal level of 30 mg/24 hour which is measured at least 2 timesin the period of 3 to 6 months. Microalbuminuria can be measured either albumin excretion rate (AER) or albumin creatinine ratio (ACR). Measurement of ACR is an alternative parameter recommended by WHO in 2011 to diagnose diabetic nephropathy since it is more convenient, fast and not requires special preparation. The purpose of this study was to investigate accuracy of ACR to diagnose DN in type 2 diabetes mellitus (T2DM) patients.This was a diagnostic test study involving 80 T2DM patients. In this study ACR value equal or more than 30 mg/g was independently and blindly compared with AER as the gold standard. The data were analyzed using 2x2 tables in order to calculate sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Other data were analyzed using statistic descriptive. Eighty T2DM patients consisting of 38males and 42 females participated in this study. They had suffered from T2DM on average9.5 years, and the average of ACR value was 55.5 mg/g. Total result of true positive andtrue negative was 77. Three result were false negative but none of false positive result.The ACR value equal or more than 30 mg/g had sensitivity, specificity, PPV, and NPV of95.9%, 100%, 100%, and 66.7% respectively. In conclusion, the ACR value equal or morethan 30 mg/g derived from morning urine sample can be used to diagnose DN in T2DMpatients.
Universitas Gadjah Mada
2017-03-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18954
10.19106/JMedScie/005003201806
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18954/pdf
Copyright (c) 2017 . Fatrinawati, . Windarwati, Osman Sianipar
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18955
2018-06-25T02:52:01Z
bik:ART
Prevalence of metabolic syndrome and its components based on International Diabetes Federation (IDF) definition in Yogyakarta Special Region, Indonesia
Jian, Choo Hao
Dewi, Fatwa Sari Tetra
Herningtyas, Elizabeth Henny
Prevalence of Metabolic Syndrome, central obesity, dyslipidemia, hypertension, Yogyakarta-Indonesia, IDF criteria
ABSTRACTMetabolic syndrome (MetS) is a group of risk factors which increase morbidity and mortality for cardiovascular disease and diabetes. The prevalence of MetS has been on the rise. No previous study has described the prevalence of MetS in Yogyakarta Special Region and its components. The study aim was to determine the prevalence of MetS and it’s components in Yogyakarta Special Region, Indonesia. A total of 766 male and female subjects aged ≥40 were analyzed in this retrospective study based on secondary data from the Indonesian Family Life Survey batch 4 (IFLS 4). MetS was defined by International Diabetes Federation (IDF) criteria with ethnicity-specific values for waist circumference. Prevalence of MetS and characteristic of each component of MetS were expressed as mean or %. The difference of the MetS components was evaluated by t-test and chi-square. Prevalence of MetS in Yogyakarta Special Region was 13.19%. The most common of MetS component was hypertension (60.44%), followed by dyslipidemia (56.27%), central obesity (32.38%), pro-inflammatory state (15.71%) and insulin resistance (0.78%). There was a higher prevalence of MetS in females compared to males (15.88 vs 10.19%), pre-elderly compared to the elderly (13.90 vs 12.19%), Javanese compared to other ethnicities (13.23 vs 10.00%), and urban compared to rural populations (15.06 vs 8.37%). In conclusion,the prevalence of MetS in Yogyakarta Special Region is 13.19% with hypertension and dyslipidemia as the most common component.
Universitas Gadjah Mada
2017-03-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18955
10.19106/JMedSci004903201705
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18955/pdf
Copyright (c) 2017 Choo Hao Jian, Fatwa Sari Tetra Dewi, Elizabeth Henny Herningtyas
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/18959
2019-11-14T07:32:11Z
bik:ART
Prevalence ratio of free fatty acid in obese group with non-alcoholic fatty liver disease
Handayani, Rosmeri
Purnamaningsih, Siti Muchayat
Sukorini, Usi
NAFLD, FFA, prevalence ratio, obese, women
Non-alcoholic fatty liver disease (NAFLD) is liver disorders characterized by macrovesicular fatty liver, fibrosis, cirrhosis that not associated with alcohol consumption. The prevalence of NAFLD has risen with a pandemic of obesity. The increase of free fatty acid (FFA) oxidation will induce endoplasmic reticulum stress that cause mitochondrial dysfunction and lead to increase reactive oxygen species (ROS) production causing apoptosis of liver cells. The aim of study was to determine the prevalence of FFA in the obese group. This was an observational analytical study with cross-sectional design to determine the prevalence ratio of FFA in the obese group with NAFLD compared to the group without NAFLD. Obese women who fulfill the inclusion and exclusion criteria were involved in this study. Five mL venous blood sample was collected for the measurement of lipid profile, liver enzyme and FFA. Fatty liver was evaluated using abdominal USG. The Chi-square test was used to analyze different proportions of FFA between the both groups. Sixty four subjects were participated in this study and classified into obese with NAFLD (39 subjects) and obese without NAFLD (25 subjects). The prevalence ratio of FFA with cutoff value ≥2.66 nmol/mL in the obese group with NAFLD was 4.3 times higher than those without NAFLD (95% IC: 3.5 – 42.3; p<0.001).
Universitas Gadjah Mada
2017-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/18959
10.19106/JMedSci005102201906
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 145-151
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 145-151
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/18959/pdf
Copyright (c) 2017 Rosmeri Handayani, Siti Muchayat Purnamaningsih, Usi Sukorini
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/19080
2019-10-31T02:47:45Z
bik:ART
SCN1A exon 26 variants in epilepsy and migraine patients
Lestari, Nova Dian
Mutiawati, Endang
Sadewa, Ahmad Hamim
Sjahrir, Hasan
Syahrul, .
Emril, Dessy Rakhmawati
Harapan, .
epilepsy - gene variation - migraine - mutation - SCN1A
Epilepsy and migraine are common neurological diseases in many populations. Mutation of the voltage gated natrium channel Nav1.1 (SCN1A) are important causes of different genetic epilepsies and can also cause familial hemiplegic migraine (FHM-III). This study aimed to identify SCN1A gene variation in patients with epilepsy and common migraine. Gene variation analysis of exon 26 of the SCN1A gene was carried out in 33 patients with epilepsy, 33 patients with migraine and 30 control individuals from Neurology Polyclinic at Dr. Zainoel Abidin General Hospital, Banda Aceh. The PCR and direct sequencing methods were performed in this study. SCN1A gene variations were identified in two epilepsy patients. These gene variations located at exon 26 were four silent mutations in patient E27 at position A4440T (Leu1480Leu), T4443C (Leu1481Leu), A5046G (Leu1682Leu) and C5121T (Asp1707Asp). One silent mutation in patient E30 at position G5505A (Glu1835Glu). None of these gene variations were identified in controls and patients with common migraine in this study. This study has identified 5 genetic variations of SCN1A in patients with epilepsy but not in common migraine. The mechanism and relationship between these variants and epilepsy need to be clarified.
Universitas Gadjah Mada
2017-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/19080
10.19106/JMedScie/005004201806
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/19080/pdf
Copyright (c) 2017 Nova Dian Lestari, Endang Mutiawati, Ahmad Hamim Sadewa, Hasan Sjahrir, . Syahrul, Dessy Rakhmawati Emril, . Harapan
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/19081
2019-11-27T01:26:21Z
bik:ART
The accuracy of fine needle aspiration biopsy to diagnose breast neoplasm
Felisha, Hifdza Faza
Rinonce, Hanggoro Tri
Anwar, Sumadi Lukman
Dwianingsih, Ery Kus
FNAB; breast lump; sensitivity; specificity; diagnosis
Breast lump is a very common complaint among women, especially during the reproductive year. Fine needle aspiration biopsy (FNAB) is a less invasive procedure. It is usually performed as an initial diagnosis prior to the operative procedure. The accuracy of the FNAB in Indonesia needs to be elaborated. The study aimed to evaluate the sensitivity and specificity of FNAB in diagnosing breast neoplasm. This is a retrospective study with cross sectional design, involving 145 patients with breast lump who underwent FNAB and histopathology examination in Dr. Sardjito General Hospital, Yogyakarta, from 2012 to 2014. Data analysis showed that female to male ratio was 23. 2:1 commonly occurred at 41-50 years old. Forty-one cases (28.28%) diagnosed as a benign lesion with fibrocystic changes as the most frequentcase (11.19%). The malignant case was 104 cases (71.72%) with ductal carcinoma as the highest case (51.49%). FNAB achieved a sensitivity of 85.58%, a specificity of 100% and a total accuracy of 89.66% in determining the benign or malignant breast lump. The accuracy, sensitivity and specificity of FNAB in diagnosing ductal carcinoma were 83.58%, 85.51% and 81.54%, respectively. The accuracy, sensitivity and specificity of FNAB to diagnose fibrocystic changes lesion were 85.82%, 26.67% and 93.28%, respectively. FNAB can be used as an alternative diagnostic tool to diagnose breast neoplasm. It provides rapid, cheaper, effective, valuable, and less invasive procedure in diagnosis of breast lump.
Universitas Gadjah Mada
2017-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/19081
10.19106/JMedSci005103201907
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 237-245
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 237-245
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/19081/pdf
Copyright (c) 2017 Hifdza Faza Felisha, Hanggoro Tri Rinonce, Sumadi Lukman Anwar, Ery Kus Dwianingsih
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/19204
2019-05-21T07:25:54Z
bik:ART
Systematic Review: Pre-Stroke Use of Angiotensin Receptor Blockers and Stroke Outcomes
Dewi, Ivana Purnama
Kusmanto, Virandra B.
Dewi, Kristin Purnama
Pinzon, Rizaldy
ARB, pre-stroke, benefit, prognosis
Background: Hypertension is the major risk factor and the most important modifiable risk factor for stroke. Angiotensin Receptor Blockers (ARB) are widely used in patient at high risk of cardiocerebrovascular events. The objective of this literature review was to determine the efficacy of pre-stroke use of ARB on stroke outcomes.Methods: Major medical databases (PubMed, MEDLINE, Clinical Key, Cochrane Library, EMBASE) were systematically searched using keyword: “hypertension”, “ARB”, “stroke”, and “outcome”. The search were limited to clinical trials published within the last 10 years, written in English, with full-text availability. We used GRADE Working Group to measure the quality of evidence.Results: Four clinical studies, three retrospective studies and one nationwide population-based cohort study met our inclusion criteria with total of 102.644 patients for analysis. The scientific quality of the studies varied from poor (1 study), moderate (1 study), and high quality (2 studies). Generally, the subjects of the studies were acute ischemic stroke patients. Three studies showed pre-stroke use of ARB were significantly associated with better stroke outcomes. Only one study found different result whereas pre-stroke use of ARB did not appear to affect stroke outcomes. Outcome of the studies was explored according to morbidity (severity and functional status upon discharge) and mortality (30-days mortality or in-hospital mortality). Several limitations were present, including non-random treatment assignment, retrospective study design, and lack of data for longitudinal medication exposure in observational studies.Conclusions: This systematic review shows evidence that there is possible benefit of pre-stroke ARB treatment in relation to better ischemic stroke outcomes. However, further studies with better research method quality are still needed. The efficacy of ARB treatment in relation to other type of stroke outcomes also needs to be furtherly examined.Keywords: ARB, pre-stroke, benefit, prognosis Makalah ini dipresentasikan dalam Poster Session 11th Scientific Meeting of Indonesian Society of Hypertension, 24-26 February 2017
Universitas Gadjah Mada
Faculty of Medicine, Duta Wacana Christian University
2018-12-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/19204
10.19106/JMedSci005002201815
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/19204/pdf
Copyright (c) 2018 Ivana Purnama Dewi, Virandra B. Kusmanto, Kristin Purnama Dewi, Rizaldy Pinzon
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/19380
2019-11-14T07:32:11Z
bik:ART
Solitary dermal cylindroma: a rare case report
Widayati, Wahyu Tri
Irianiwati, .
dermal cylindroma – solitary – PAS - p63 - CD1a
Dermal cylindromas are rare benign skin appendageal tumors that has two clinical presentation, solitary and multiple form. The diagnosis is unusual.However, it must be considered in clinical practice.A 51-year-old woman hadpainless nodule on right arm. Skin examinatipn revealedtwo fragmented nodules, 1x0.5x0.5cm, tan to white, and rubbery. Histopathological findings revealed a well demarcated and an unencapsulated epithelial dermal tumor, composed of numerous oval and polygonal nests molded into a "jig-saw" or "mosaic" appearance at low power. The nests of cells were composed of basaloid cells with scant cytoplasm and hyperchromatic nuclei and paler cells at the center. Nests of epithelial cells were surrounded and penetrated by a thickened band of basement membrane material that was PAS-positive. Immunohistochemistry (IHC) staining with p63 showed positive staining on basaloid cells. Langerhans dendritic cells in the surrounding nests stained positive with CD1a. Solitary dermal cylindroma occurred sporadically in patients without family history of cutaneous cylindromas.Combination of morphologic, histochemystry and immunohistochemystry staining were needed for accurate diagnosis.
Universitas Gadjah Mada
2019-07-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/19380
10.19106/JMedSci005102201910
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 181-187
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 2 (2019); 181-187
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/19380/pdf
Copyright (c) 2019 Wahyu Tri Widayati, . Irianiwati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/22626
2019-08-05T07:20:12Z
bik:ART
Comparison of Bcl-xL protein expression in placental trophoblast cells between pregnancy complicated by severe preeclampsia and normotensive pregnancy
Hadiati, Diah Rumekti
Palupi, Arsi
Hakimi, Mohammad
Haryana, Sofia Mubarika
trophoblast; severe preeclampsia; Bcl-xL protein; apoptosis
Preeclampsia is one of the main causes of maternal and perinatal mortality and morbidity.The pathogenesis of preeclampsia remains unclear until now. It is believed thatregulation of apoptosis in trophoblast cells plays an important role in the pathophysiologyof preeclampsia. Failure of spiral arteries remodeling will eventually lead to placentalhypoxia lead to excessive trophoblast apoptosis. The molecular mechanism of apoptosisis very complicated involving many signaling molecules included Bcl-2 proteins. The Bcl-2 protein group consists of proapoptosis proteins (Bax) and apoptosis inhibitor proteins(Bcl-2 and Bcl-xL). The aimed of this stuty was to compare the expression of Bcl-xLprotein in placental trophoblast cells of pregnancy complicated by severe preeclampsiawith that normotensive pregnancy. This study was an observational study with crosssectional design involving 43 pregnancy patients with severe preeclampsia and 38normotensive pregnancy who treated in Dr. Sardjito General Hospital, Yogyakarta fromOctober 2011 until March 2012. Placenta samples were obtained from all subjects forBcl-xL protein expression analysis using immunohistochemistry technique. Data wereanalyzed using independent t-test, chi-square test, and logistic regression. A p value<0.05 was considered significant. Significant difference in Bcl-xL protein expressionin trophoblast cells of pregnancy complicated by severe preeclampsia (1.29 ± 0.12)compared to that normotensive pregnancy (1.71 ± 0.14) was reported (p = 0.00). Inaddition, logistic regression test showed that diagnosis of severe preeclampsia had astatistically significant role in Bcl-xL protein expression (p= 0.000). In conclusion, theexpression of Bcl-xL protein is lower in pregnancy complicated by severe preeclampsiacompared to normotensive pregnancy.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/22626
10.19106/JMedSci005001201804
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/22626/pdf
Copyright (c) 2018 Diah Rumekti Hadiati, Arsi Palupi, Mohammad Hakimi, Sofia Mubarika Haryana
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/23884
2019-08-08T05:40:18Z
bik:ART
Precocious puberty in McCune-Albright syndrome: a case report
Lestari, Rianti Puji
Sutomo, Retno
Julia, Madarina
McCune-Albright syndrome - precocious puberty – tamoxifen – genetic disorders - gonadotropins
McCune-Albright syndrome (MAS) is a rare disease characterized by a triad of fibrousdysplasia, cafe-au-lait spots and peripheral precocious puberty. We reported a 5-year-8-month old girl with MAS who has been followed-up for 2 years and 8 months. Shewas referred to pediatric endocrinology clinic in our hospital for vaginal bleeding at ageof 2 years 11 months. She had peripheral precocious puberty, i.e. increased estrogenlevel associated with very low gonadotropins, and cafe-au-lait spots on her face and wasdiagnosed as MAS. The patient was treated with estrogen receptor blocker (tamoxifen).She had no menses during the 2 years and 8 months of tamoxifen treatment. Her growthrate and bone maturation were also in normal ranges. However, at the end of tamoxifentreatment she had an episode of vaginal bleeding so that we had to change to othertreatment modalities.
Universitas Gadjah Mada
2018-12-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/23884
10.19106/JMedScie/0050032018014
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/23884/pdf
Copyright (c) 2018 Rianti Puji Lestari, Retno Sutomo, Madarina Julia
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/24710
2019-08-08T06:04:08Z
bik:ART
Development of motor learning implementation for ischemic stroke: finding expert consensus
Rahayu, Umi Budi
Wibowo, Samekto
Setyopranoto, Ismail
model development - application of motor learning - ischemic stroke - expert consensus - neurorestoration
The main purpose of this study was to investigate motor learning implementation forischemic stroke from experts on the field of motor learning in stroke patients includingthe neurologist, medical rehabilitation specialists and physiotherapists. To collect thedata and answer the research questions, statements were made on the basis of thestudy of literature and the grains exploration of the statements in the questionnaire usingthe Delphi Method. Formulation development model was based iteration or judgmentof experts. Validation assessment statement grain tested by the Content Validity Ratio(CVR) and Content Validity Index (CVI) was used to analyze the data. The finding clearup that CVR value of each item statement was 1 and the value of CVI also 1. There were6 indicators in a 26-point declaration on the implementation of the development model ofmotor learning intervention for ischemic stroke. Six indicators included basic theories thatsupport the importance of intervention motor learning, motor learning stages, principlesof motor learning, dosage, timing of and kinds of motor learning interventions that can beprovided as well as application development intervention model motor learning, allowinggiven for ischemic stroke. In conclusion, based on the content validity of the results ofthe consensus expert judgments are six indicators of the importance of motor learningapplication for ischemic stroke.
Universitas Gadjah Mada
2017-12-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/24710
10.19106/JMedSci004904201706
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 200-216
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 200-216
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/24710/pdf
Copyright (c) 2017 Umi Budi Rahayu, Samekto Wibowo, Ismail Setyopranoto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/24920
2019-08-05T07:20:12Z
bik:ART
Insecticide resistance and mechanisms of aedes aegypti (Diptera: Culicidae) in Yogyakarta, Indonesia
Mulyaningsih, Budi
Umniyati, Sitti Rahmah
Satoto, Tri Baskoro Tunggul
Diptyanusa, Ajib
Nugrahaningsih, Dwi Aris Agung
Selian, Yahiddin
Organophosphate; pyrethroid; biological assay; biochemical assay; molecular assay
For several decades, applications of organophosphates and pyrethroids insecticides have been extensively used to control Aedes aegypti as the primary dengue vector. Hence it is important to study dengue vector resistance status and its mechanisms in relation to long term use of insecticides. This study aimed to determine the resistance status and to characterize mechanisms of Ae. aegypti to organophosphates and pyrethroids using biological, biochemical and molecular assays. Larvae and puppae of Ae. aegypti were collected in the field of Plosokuning, Minomartani, Sleman, Yogyakarta, Indonesia. The biological assay was carried out using CDC Bottle Bioassay to test the resistant status to malation and cypermetrin. The biochemical assay was conducted using microplate assay with substrate α-naphthyl acetate to test the presence of esterase elevated activity, and the molecular assay was done using PCR with AaSCF7 and AaSCR7 primer to detect of point mutation at 1534 site, that located in the area of segment 6 of domain III. The biological assay showed Ae. aegypti suggests the possibility of resistance to malathion (mortality 82%) that needs to be confirmed further and already resistant to cypermetrin (mortality 76%). The biochemical assay of Ae. aegypti showed the presence of non-specific esterase elevated activity. The PCR method showed specific DNA bands were formed with the size of 748bp, and with sequencing showed there has been F1354C point mutation of voltage gated sodium chanel gene in the area of segment 6 of domain III. Long term use of insecticides did not successfully eliminate the targeted dengue vector, because Ae. aegypti mosquitoes were resistant to both insecticides. The results demonstrate the importance of designing better health policies regarding insecticide usage
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/24920
10.19106/JMedSci005001201803
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/24920/pdf
Copyright (c) 2018 Budi Mulyaningsih, Sitti Rahmah Umniyati, Tri Baskoro Tunggul Satoto, Ajib Diptyanusa, Dwi Aris Agung Nugrahaningsih, Yahiddin Selian
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/25465
2020-06-01T06:13:40Z
bik:ART
The prognostic value of lymph nodes mRNA CXCL12 expression in the breast cancer
Safitri, Idha
Widodo, Irianiwati
Heriyanto, Didik Setyo
breast carcinoma; CXCL-12 mRNA expression; lymph nodes; metastasis; prognostic factor;
Prognosis of breast carcinoma is influenced by age, tumor size, histological grade and type, lymph node status, as well as metastasic status. Chemokine receptor CXCR-4 with its ligand, CXCL-12, may play an important role in metastasis of breast carcinoma. However, the role of CXCL-12 mRNA as a prognostic factor and a therapeutic target of human breast cancer remains controversial. This study aimed to investigate the level of CXCL-12 mRNA expression in lymph nodes of patients with invasive ductal breast carcinoma and the difference within the prognostic factors. Axillary lymph nodes obtained from 50 cases of invasive ductal breast carcinoma, were divided into two groups, with and without lymph node metastasis. Each group consisted of 25 cases. Total RNA was extracted from formalin-fixed paraffin-embedded. The CXCL-12 mRNA expression was examined using qRT-PCR method. The mean differences between the two groups were analyzed using Mann-Whitney test. The differences between CXCL-12 mRNA expression and each prognostic factor ware analyzed using Mann-Whitney comparison test. CXCL-12 mRNA expression was significantly higher in the lymph node of patients with metastasis of breast carcinoma compared to the non-metastasis cases (p<0.01). There were significant differences between CXCL-12 mRNA expression with poorly histological grade (p=0.003), bigger primary tumor size (p=0.005) and age of ≥45 y.o (p=0.012) in the metastatic group, but there were no significant differences between both age of <45 and ≥45 y.o.This study suggests that the higher CXCL-12 mRNA expression level are associated with bigger tumor size and poor differentiation in breast cancer patient with lymph nodes metastasis
Universitas Gadjah Mada
2019-10-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/25465
10.19106/JMedSci005202202002
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 2 (2020)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 2 (2020)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/25465/pdf
Copyright (c) 2019 idha safitri, Irianiwati Widodo, Didik Setyo Heriyanto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/25763
2019-08-08T05:40:18Z
bik:ART
Factors influencing plateletpheresis donations in Yogyakarta, Indonesia
Wicaksana, Aditya
Triyono, Teguh
Intansari, Umi
platelet – plateletpheresis – pre-donation – post-donation - platelet count- product
Despite its life saving potential, regrettably, blood transfusion has yet to be optimally applied in Indonesia. Funding difficulties and both public and professional lack of knowledge hinders its progress. More lives can be saved by using a safer, more proper, and specialized blood transfusion procedure. Plateletpheresis, one method to obtain platelet products, requires a different donation procedure than that of whole blood-derived platelet. High quality plateletpheresis product donation will positively impact the transfusion efficacy and platelet recovery of the recipient, improving patient’s clinical state. This study analyzes factors from both the donor and donation procedure that influence the quality of plateletpheresis product. The study analyzes data of plateletpheresis donations from blood transfusion service and plateletpheresis transfusions from medical records at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, within the period of August 2012 to January 2013 using cross sectional design. Forty-four plateletpheresis donations were obtained during the study. All donors were male with the following mean values; age 31.9 ± 9.9 years, weight 70.2 ± 10.2 kg, body mass index (BMI) 24.7 ± 3.2 kg/m2, hematocrit 44 ± 3.2 %, and procedure time 84.2 ± 19.2 min. The median value of platelet yield was 3.2x1011 (2.1x1011 – 4x1011). The median value of pre-donation platelet count was 248.5x103/μL (204x103/μL – 391x103/μL) and the mean value of product volume was 275 ± 22.9 mL. The results showed that pre-donation platelet count (r = 0.329; p < 0.05) and product volume (r = 0.661; p < 0.05) positively correlated to the yield of platetetpheresis products. However, the yield of plateletpheresis products was not correlated to the post-transfusion platelet count (r = 0.327; p > 0.05). In conclusion, pre-donation platelet count and product volume of plateletpheresis influence the yield of plateletpheresis. However, the yield is not correlated to the post-donation platelet count. Thus, other clinical factors should be considered
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/25763
10.19106/JMedScie/005003201809
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/25763/pdf
Copyright (c) 2018 Aditya Wicaksana, Teguh Triyono, Umi Intansari
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/25959
2019-08-08T05:40:18Z
bik:ART
Peppermint oil prevented oxidative stress in experimental animal – induced acute single bout of eccentric exercise (ASBEE): study on blood catalase and hydrogen peroxide (H2O2) and glucose transporter-4 (GLUT-4) expression on the muscle cells
Aryanti, Dewi
Agustiningsih, Denny
Wahyuningsih, Mae Sri Hartati
peppermint oil - acute single bout of eccentric exercise - glucose transporter-4 - catalase - hydrogen peroxide
Peppermint oil is one of the essential oils with antioxidant activity that can reduce levels of reactive oxygen species (ROS). An acute single bout of eccentric exercise (ASBEE) is an acute exercise activity that can lead to increased ROS and cause skeletal muscle injury. This study aimed to assess the effect of peppermint oil in experimental animals induced with ASBEE with the purpose to measure catalase, hydrogen peroxide (H2O2) blood and glucose transporter-4 (GLUT-4) expression of skeletal muscle cells. A total of 30 Wistar rats (Rattus norvegicus) aged 20-24 weeks, weighing 160-350 g were divided into six groups i.e. T1 (n =5), T2 (n =4) and T3 (n =5) given peppermint oil orally at different dose of 0.25, 0.5 and 1.0 g/kg, respectively, one hour before inducing with ASBEE; C0 (n=5) not given peppermint oil and not induced with ASBEE; CA (n=5) not given peppermint oil and induced with ASBEE and CE (n=5) given vitamin E 400 mg/kg one h before induced with ASBEE. ASBEE induction was done by downhill running on a rat treadmill -50 with a load index of 70% VO2 max for 30 min. Twenty four h after induction of ASBEE, blood samples and muscle tissue were taken for examination of catalase, H2O2 and GLUT-4 expression. The results showed increased levels of blood catalase and decreased blood H2O2 levels in groups T1, T2, T3, and CE. The opposite occurred in the group CA. The GLUT-4 expression did not show any significant difference between groups. It was concluded that peppermint oil can improve the condition of oxidative stress caused by ASBEE.
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/25959
10.19106/JMedScie/005003201802
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/25959/pdf
Copyright (c) 2018 Dewi Aryanti, Denny Agustiningsih, Mae Sri Hartati Wahyuningsih
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/26048
2019-08-05T07:20:12Z
bik:ART
The SLCO1B1*15 haplotype associated with lower clinical outcome in Indonesian tuberculosis patients
Ang, Sunarto
Nugroho, Akhmad Kharis
Sadewa, Ahmad Hamim
Hakim, Lukman
Mustofa, .
SLCO1B1*15 haplotype; rifampin; tuberculosis; clinical outcome
Rifampin is one of first-line drugs for the treatment of tuberculosis. In Indonesia nearly alltuberculosis patients show lower rifampin plasma concentrations possibly due to genetics.Rifampin is a substrate of the organic anion-transporting polypeptide 1B1 (OATP 1B1)encoded by the solute carrier organic anion transporter family member 1B1 (SLCO1B1).This study aimed to identify haplotype polymorphisms of tuberculosis drug transporterswith an impact on clinical outcome in tuberculosis patients. Thirty-six patients from AbdulWahab Sjahranie General Hospital, Samarinda, East Kalimantan were involved in thestudy. Buffy coat from patient blood samples were tested for SLCO1B1 and SLCO1B3polymorphisms by RFLP and ARMS PCR, whereas the clinical outcome was examinedbased on the sputum conversion. The frequency of patients with SLCO1B1*15 haplotypewas 63.9%. The SLCO1B1*15 haplotype was associated with susceptibility to failureof clinical outcome (p=0.005; RR=4.52; 95% CI: 1.22-16.64). The OATP1B1*15haplotype revealed that the failure of clinical outcome was markedly increased comparedto the three other haplotypes. These results suggest that the SLCO1B1*15 haplotypeis an important predisposing factor for lower clinical outcome. Our data indicate thatindividualized treatment should be considered for Indonesian tuberculosis patients basedon genetics characteristics of patients.
Universitas Gadjah Mada
2018-03-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/26048
10.19106/JMedSci005001201806
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/26048/pdf
Copyright (c) 2018 Sunarto Ang, Akhmad Kharis Nugroho, Ahmad Hamim Sadewa, Lukman Hakim, . Mustofa
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/26241
2019-08-08T05:40:18Z
bik:ART
The role of Malassezia sp, sebum level and Trans Epidermal Water Loss (TEWL) toward the dandruff severity between hijab and non hijab wearing subjects
Etnawati, Kristiana
Siswati, Agnes Sri
Pudjiati, Satiti Retno
Susetiati, Devi Artami
Adiwinarni, Dwi Retno
Purbananto, Affendi
dandruff severity - Malassezia sp - sebum - TEWL - hijab
Dandruff is a common symptom in adolescence, which possibly due to increasing ofMalassezia sp. colonization, sebum level as well as skin hydration. Wearing hijab ispredicted to increase the humidity and sebum level lead to increase the number ofMalassezia sp. and dandruff severity. A case-control study was conducted on 19 femalewith dandruff who wear hijab and 19 female with dandruff who do not wear hijab, agebetween 18 and 27 years old. The dandruff severity was defined clinically using ascoring system (0-100), only subjects with minimum score of 28 will be included in thisstudy. The sebum and trans epidermal water loss (TEWL) levels were measured withSebumeter and Tewameter from Courage Khazaka. The Malassezia sp. was examinedusing microscopic examination of the squama and culture in the Saboraud medium.There were no significant differences found between hijab and non-hijab groups fordandruff severity. No difference found between two groups for sebum level, Malasseziasp. number microscopically, and Malassezia sp. colonization. Only TEWL level in hijabgroup that was found to be higher than non-hijab group. Wearing hijab does not increasethe dandruff severity, sebum level and colonization number of Malassezia sp. Wearinghijab is found to increase the TEWL level.
Universitas Gadjah Mada
2018-11-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/26241
10.19106/JMedScie/0050032018011
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/26241/pdf
Copyright (c) 2018 Kristiana Etnawati, Agnes Sri Siswati, Satiti Retno Pudjiati, Devi Artami Susetiati, Dwi Retno Adiwinarni, Affendi Purbananto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/26422
2021-01-20T07:41:54Z
bik:ART
Incidental bladder wall alteration as a surgical complication risk factor in Indonesian benign prostate hyperplasia patient
Krisna, Daniel Mahendra
Maulana, Akhada
Kresnoadi, Erwin
benign prostate hyperplasia; bladder wall alteration; complication; comorbid; trans urethra resection of prostate;
Bladder obstruction due to benign prostatic hyperplasia (BPH) causes bladder walls alteration such as trabecular and diverticula. Although it is asymptomatic, however it affects the surgery complication. The aim of this study was to evaluate the correlation between bladder wall alteration and post-surgery complications in BPH patients. It was a descriptive observational study with cross-sectional design involving BPH patients who underwent histopathological examination and surgical intervention in the Bhayangkara Hospital Mataram from January 2010-December 2014. Data of the patients including age, place of birth, intraoperative finding, comorbid condition, and post-surgery complication were obtained from the medical record. The relationship between variables was analyzed using Pearson correlation test and linear regression test.A total 114 subjects were involved in this study with the most common age was in the range 60-69 years (43.0%). Seventy-fivesubjects (74.3%) had trans urethra resection of prostate (TURP). Trabecula (28.7%), diverticula (4.0%), and bladder stone (10.9%) were found when the surgical intervention performed. The most common post-surgical complication was chip or clot retention (56.4%). Significantly relationship betweenintraoperative finding with post-surgical complication was observed (r= 0.265; R2 = 0.07; p<0.05). In conclusion, there is correlation between bladder wall alteration and post-surgicalcomplication in BPH patients. Early bladder wall alteration screening is suggested in BPH patients before surgical intervention performed.
Universitas Gadjah Mada
2020-10-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/26422
10.19106/JMedSci005204202005
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 4 (2020)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 4 (2020)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/26422/pdf
Copyright (c) 2020 Daniel Mahendra Krisna, Akhada Maulana, Erwin Kresnoadi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/26601
2019-11-14T07:31:53Z
bik:ART
Critical appraisal of neuropathic pain guidelines in Asia
Pinzon, Rizaldy Taslim
Sanyasi, Rosa De Lima Renita
systematic review, neuropathic pain, guidelines, Asia
Neuropathic pain (NP) is type of chronic pain that is common and often difficult to treat. Clinicians may be guided by a number of published guidelines and algorithms for the management of neuropathic pain. It is important for every clinician to know the quality of guidelines. The availability of current guideline in Asian countries is not well understood. Critical appraisal of NP guidelines in Asia has not performed, yet. The aim of this study was to appraise the quality of pharmacological treatment from neuropathic pain guidelines in Asia. Systematic searches were conducted by using combination of keywords i.e NP, Asia, and guideline. Guidelines evaluation was using appraisal of guidelines for research & evaluation II (AGREE II) instrument. The result interpreted as (i) a strongly recommended for use in practice if most domains scored above 50%; (ii) recommended for use with some modification if most domains scored between 30% to 50%; or (iii) not recommended for use in practice if most domains scored below 30%. After matched to inclusion and exclusion criteria there were 5 guidelines left: a guideline from Philippines, China, South Korea, Malaysia and Middle East. All of guidelines are recommended for use with some modification. The guidelines mention that first line treatment for NP are tricyclic antidepressants, selective norepinephrine reuptake inhibitor (SNRI) and alpha 2-delta ligand calcium channel blocker (CCB). Most of the evidences come from peripheral NP. There were limited evidences for the treatment of central neuropathic pain (central post stroke pain and pain after spinal cord injury). All the existing guideline mention, that the first line treatment for neuropathic are the tricyclic antidepressants, SNRI and alpha 2-delta ligand CCB.
Universitas Gadjah Mada
2019-04-11
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/26601
10.19106/JMedSci005101201909
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 1 (2019); 73-81
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 1 (2019); 73-81
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/26601/pdf
Copyright (c) 2019 Rizaldy Taslim Pinzon, Rosa De Lima Renita Sanyasi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/27679
2019-11-27T00:49:27Z
bik:ART
The effect of L-arginine therapy on hepatocyte cells damage in mice (Mus musculus) model of preeclampsia
Soetrisno, S
Arinekso, Bambang
Sulistyowati, Sri
L-arginine; hepatocytes cell; preeclampsia; mouse model; animal model
Preeclampsia is one of the main contributors on morbidity and mortality of mother and fetus. Imbalance of body antioxidants and oxidants has a role on endothelial destruction causing endothelial dysfunction which leads to preeclampsia. L-arginine administration is indicated to be able to fix the remodelling process of hepatocytes which was damaged on preeclampsia. The aim of this study was to investigate the effect of L-arginine on hepatocyte cells damage on mouse (Mus musculus) model of preeclampsia. Experimental study was conducted in the Experimental Animal Warehouse and Biomedical Laboratory, Faculty of Veterinary Medicine, Airlangga University, Surabaya. A total of 30 pregnant mice were divided into three groups with 10 mice in each group i.e. normal, preeclampsia model and preeclampsia model with L-arginine therapy pregnant mice. Preparates were taken from dissected mice liver, with prior paraffin block and were then stained with hematoxylin-eosin. Results were analyzed semi quantitatively with Manja Roenigk hepar histology scoring method. Data were analyzed using Kruskal-Wallis and Man-Whitney test. Mean of hepar histopathology score of preeclampsia model with L-arginine therapy (40.80±1.17/µm2) was significantly lower compared with preeclampsia model pregnant mice (58.80±4.23/µm2) (p<0.05), however it was significantly higher compared with normal pregnant mice (18.40±2.41/µm2) (p<0.05). It was indicated that the L-arginine therapy on preeclampsia mouse model can reduce the score of hepar histopathology. In conclusion, L-arginine administration can reduce the hepatocyte cells damage of mouse due to preeclampsia.
Universitas Gadjah Mada
2019-09-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/27679
10.19106/JMedSci005104201905
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 316-324
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 316-324
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/27679/pdf
Copyright (c) 2019 S Soetrisno, Bambang Arinekso, Sri Sulistyowati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/27787
2019-11-26T06:35:56Z
bik:ART
Effect of tagitinin C isolated from Tithonia diversifoli (Hemsley) A Gray on migration activity and TGF-β1 levels on keloid fibroblast
Santi, Elvira
Wahyuningsih, Mae Sri Hartati
Budiyanto, Arief
Keloid fibroblast; Proliferation; Tagitinin C; TGF-β1 Level
Keloid is the formation of excessive scar tissue characterized by fibroblast hiperproliferations and collagen deposits that are similar with cancer cells. Tagitinin C is proven can inhibit proliferation and deposition of keloids collagen fibroblast. However, the mechanism of action of tagitinin C in migration activities and TGF-β1 levels of keloid fibroblasts has not been proved, yet. This study aimed to investigate the effects of tagitinin C isolated from Tithonia diversifoli (Hemsley) on migration activity and TGF-β1 expression of keloid fibroblast. This was quasi experimental study with post test only controlled group design using keloid fibroblasts isolated from keloid patients. The migration activity were performed by scratch assay and TGF-β1 levels were measured using an ELISA kits. Isolate tagitinin C was more active inhibit fibroblast keloid migration compare to the control groups (p<0.05) after 48 h incubation. TGF-β1 levels after incubation with isolate tagitinin C was lower then control group (p<0.05). In conclusion, isolate tagitinin C can inhibit migration and reduce TGF-β1 levels on keloid fibroblast
Universitas Gadjah Mada
2019-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/27787
10.19106/JMedSci005103201901
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 188-194
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 188-194
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/27787/pdf
Copyright (c) 2019 Elvira Santi, Mae Sri Hartati Wahyuningsih, Arief Budiyanto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/28367
2019-11-27T00:49:27Z
bik:ART
Genetic polymorphism in DNA base excision repair gene XRCC1among medical radiation workers
Surniyantoro, Harry Nugroho Eko
Lusiyanti, Yanti
Mailana, Wiwin
Tetriana, Devita
DNA damage; XRCC1; genetic polymorphism; DNA repair; medical radiation workers
X-rays repair cross-complementing group 1 (XRCC1) gene is one of the gene that plays an important role in base excision repair system (BER) and DNA repair both single and double strand breaks. Individuals with XRCC1 exon 10 (Arg399Gln) gene polymorphisms and carrying 399Gln allele variants (A allele) have a greater risk of DNA damage than their wildtype, 399Arg. The aim of this study was to examine the genotype frequencies of single nucleotide polymorphisms (SNPs) of XRCC1 exon 10 among medical radiation workers. This study involved 77 samples from several hospitals in Indonesia. Genotyping of XRCC1 exon 10 gene polymorphism was performed using PCR-RFLP. Individuals carryingA allele had lower frequency than that is carrying their wildtype of 399Arg (0.39 vs. 0.61). The results indicated that 39% of medical radiation workers had a risk of repair efficiency of DNA damage and might influence an individual's risk of cancer. Ionizing radiation induces many types of damage to DNA, requiring multiple repair pathways to restore genomics integrity. Other important genes/pathways, especially those for DNA double-strand break repair, might also play a role and should be further investigated. Furthermore, polymorphisms leading to inefficient DNA repair might also be associated with late reactions to radiotherapy.
Universitas Gadjah Mada
National Nuclear Energy Agency of Indonesia
2019-09-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/28367
10.19106/JMedSci005104201903
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 301-308
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 301-308
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/28367/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/28367/2724
Copyright (c) 2019 Harry Nugroho Eko Surniyantoro, Yanti Lusiyanti, Wiwin Mailana, Devita Tetriana
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/28560
2019-10-31T02:47:45Z
bik:ART
Expression of circulating miR-200c and vascular endothelial growth factor-A (VEGF-A) mRNA as potential biomarker in human hepatocellular carcinoma
Qoriansas, Nanda
Renovaldi, Dede
Raditya, Juwita
Lestari, Puji
Gumilas, Nur Signa
Suharno, .
Heriyanto, Didik Setyo
Ratnasari, Neneng
Mubarika H, Sofia
blood plasma - hepatocellular carcinoma - miR-200c - mRNA VEGF-A - biomarker
Hepatocellular carcinoma (HCC) is a common liver disease that causes significant publichealth problems throughout the world, including in Indonesia. The HCC is the six mostcommon cancers and second cancer-related deaths among men in the world. Recentlyit was reported that the microRNA is an important player in hepatocarcinogenesis. Theexpression of MiRNA-200c is often regulated in primary HCC and HCC cell lines. Vascularendothelial growth factor-A (VEGF-A) is a regulator of angiogenesis that has been reportedas miR-200c target gene. This study was conducted to measure expression levels in miR-200c and mRNAVEGF-A and their potential role as biomarkers at HCC. A total of 36HCC patients and 36 healthy subjects were included in this study. The relative expressionof miRNA-200c and mRNA VEGF-A was quantified using reverse transcription real timequantitative PCR (qRT PCR). Relative expression was calculated using . Unpaired t-testwas used to compare the expression levels of circulating miRNA-200c and mRNA VEGF-Ain HCC patients and healthy subjects. Pearson test was used to determine correlationbetween circulating miR-200c expression and mRNA VEGF-A expression levels. Theexpression levels of circulating miR-200c in HCC patients were lower compared to healthysubjects although it was not significant (p = 0.258). Conversely, the expression levelsof circulating mRNA VEGF-A in HCC patients were significantly higher compared tohealthy subjects (p = 0.001). The relative expression levels of circulating miR-200c werenegatively correlated with mRNA VEGF-A in HCC patients. In conclusion, the expressionlevels of mRNA VEGF-A in HCC patients are significantly deregulated in compared tothat in healthy subjects. Negative correlation between circulating miRN-200c and mRNAVEGF-A expression levels are reported in HCC patients.
Universitas Gadjah Mada
LPDP (lembaga pengelola dana pendidikan),
2019-01-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/28560
10.19106/JMedScie/005004201805
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 4 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/28560/pdf
Copyright (c) 2019 Nanda Qoriansas, Dede Renovaldi, Juwita Raditya, Puji Lestari, Nur Signa Gumilas, . Suharno, Didik Setyo Heriyanto, Neneng Ratnasari, Sofia Mubarika H
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/28665
2019-05-22T07:08:09Z
bik:ART
Life style risk factors for femoral neck fracture in Dr. Sardjito Hospital
Fahry, Helmiza
Yuwana, Sugeng
femoral neck fracture, corticosteroid, coffee, visual acuity, sport
As life expentancy improved, the incidence of femoral neck fracture, as one of the mostcommon traumatic injuries in the elderly, has also increased. Risk for fracture is not onlydetermined by age and sex but also by the degree of osteoporosis and certain life-styles.The purpose of this study was to investigate life-style risk factors for femoral neck fracturein Dr. Sardjito General Hospital, Yogyakarta. In this case-control study, all patients withfemoral neck fractures admitted to the Orthopedic Division and Traumatology, Departmentof Surgery in 2013 – 2014 was included as cases. Controls were subjects withoutfracture of similar age and sex. Data of corticosteroid use, habitual coffee consumption,visual acuity disorders, habitual use of slippers and engagement in routine sport activitywere collected with questionnaires. We invited 63 patients (51 females and 12 males)and 63 controls. Corticosteroid use, habitual coffee consumption, visual acuity disorderand habitual use of slippers were risks factors for fractures, OR (95% CI) = 7.5 (2.9-21.6), p < 0.001; 7.5 (2.9-21.6), p < 0.001; 3.2 (1.6-6.8), p < 0.001 and 5.7 (2.7-12.6), p < 0.001, respectively. Engagement in routine sport activity was a protectingfactor, OR (95% CI) = 0.10 (0.02-0.33), p < 0.001. In conclusion, corticosteroid use,habitual coffee consumption, visual acuity disorder and habitual use of slippers are riskfor fractures, while engagement in routine sport is a protecting factor
Universitas Gadjah Mada
2018-11-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/28665
10.19106/JMedSci005002201812
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/28665/pdf
Copyright (c) 2018 Helmiza Fahry, Sugeng Yuwana
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/28875
2019-08-08T06:04:08Z
bik:ART
Non infectious risk factors in pediatric sensorineural hearing loss
Rianto, Bambang Udji Djoko
Herwindo, Bondan
Prasetyo, Ashadi a
Radity, Anggoro Eka
pediatric sensorineural hearing loss – risk factors – non infectious risk factors – low birth weight - asphyxia
Pediatric sensorineural hearing loss can cause delay in speech and daily socialcommunication. The causative factors are infectious or non infecious. The role ofinfectious risk factors in pediatric sensorineral hearing loss has been proven. However,the role of non infectious factors has not been reported, yet. The aim of the study was toevaluate the role of non infectious factors in pediatric sensorineural hearing loss (SNHL).This was a case control study using data collected from outpatients and medical recordsin Dr. Sardjito General Hospital, Yogyakarta from June to December 2015. The inclusioncriteria of case group were children with SNHL and aged 0 – 5 years old, whereasthe inclusion criteria of control group was children with normal hearing and aged 0-5years old. The exclusion criteria were children with history of infectious risk factors andhead trauma. Hearing status were determined by Otoacoustic Emission Testing (OAE)and Brainstem Evoked Response Auditory (BERA), based on a= 5%, b = 20%; ORasumption = 3.0. Sixty two subjects were selected with 31 subjects in each group.Multivariate analysis showed that low birth weight (LBW) (p=0.018; OR=6.553; 95%CI=1.38 – 31.13) and asphyxia (p= 0.041; OR=6.448; 95% CI=1.077 – 38.595)were risk factors, while hyperbilirubinemia (p= 0.382; OR=2.46; 95% CI=0.365 –13.805) and gestation (p=0.876; OR=0.831; 95% CI=0.081 – 8.483) were not riskfactors for pediatric SNHL. In conclusion, LBW and asphyxia are risk factors for pediatricSNHL, whereas prematurity and hyperbilirubinemia are not risk factors.
Universitas Gadjah Mada
2017-12-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/28875
10.19106/JMedSci004904201703
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 175-182
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 4 (2017); 175-182
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/28875/pdf_1
Copyright (c) 2017 Bambang Udji Djoko Rianto, Bondan Herwindo, Ashadi a Prasetyo, Anggoro Eka Radity
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/28947
2019-05-21T07:24:38Z
bik:ART
Hearing treshold before and after middle ear surgery in chronic suppurative otitis media (CSOM)
Rianto*, Bambang Udji Djoko
Suwardi, .
Samodra, Edhie
chronic suppurative otitis media – hearing threshold – middle ear surgery – tympanoplasty - audiometry
Hearing loss is a common symptom in chronic suppurative otitis media (CSOM),often cause social communication disturbance. Canal wall up tympanoplastyand canal wall down tympanoplasty are surgery procedures for managing thisdisease that no response to convensional treatment. These surgery proceduresshould consider to hearing function impact. The aim of this study was to evaluatethe difference hearing threshold between before and after middle ear surgeryon CSOM patients. It was an historical cohort study conducted from January2015 to December 2016 involving CSOM patients who underwent canal wall uptympanoplasty surgery and canal wall down tympanoplasty in The Otology Division,Departement of Ear, Nose, Throat, Head and Neck Health, Dr. Sardjito GeneralHospital, Yogyakarta. The inclusion criteria included basic data, diagnostics,surgery reports, and audiometry results before and 3 months postoperatively,while the exclusion criteria were not complete medical record data. Total of 64patients with CSOM were involved in this study consisting of 32 patients whounderwent canal wall up tympanoplasty and 32 patients who underwent canal walldown tympanoplasty. Significantly different in the increasing of hearing thresholdbetween before and after canal wall up tympanoplasty surgery compared to thecanal wall down tympanoplasty was observed (p = 0.021). In addition, surgicaltechnique was the main factor affecting postoperative hearing threshold in CSOMpatients (p < 0.05). In conclusion, the increasing of hearing threshold in CSOMpatients underwent canal wall up tympanoplasty surgery is better than those underwentcanal wall down tympanoplasty.
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/28947
10.19106/JMedSci005002201811
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/28947/pdf
Copyright (c) 2018 Bambang Udji Djoko Rianto*, . Suwardi, Edhie Samodra
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/30304
2019-11-27T01:26:56Z
bik:ART
The analysis of cell damage of liver and kidney among alcoholics in Yogyakarta, Indonesia
Suhartini, S
Widagdo, Hendro
Nurhantari, Yudha
Wiraagni, Idha Arfianti
alcohol; liver; kidney cell damage
Alcohol tends to disrupt the organs function of human body, even can cause serious and chronic damage. In Indonesia, the data on cell damage taken from organs including the livers and kidneys among alcoholics are still practically unknown. The aim of this study was to compare the differences of organs’ cell disturbance between alcoholics and non-alcoholics in Yogyakarta, Indonesia. A crosssectional study was conducted among 197 people in Yogyakarta, including 96 alcoholics and 101 non-alcoholics. The material of the study was taken from venous blood samples. A kinetic photometric test was conducted to obtain data on blood-chemical markers’ value of livers (SGOT, SGPT, and GGT), and kidneys (BUN and serum creatinine). The data werethen analyzed by Chi square test.From a total of 96 alcoholics, 83.6% are males and 16.4% are females who consumed alcohol for an average of 16 years, with 51.6% routinely consuming it daily. The kind of alcohol they consumed was single-brand (59.8%). Based on 25th percentile (GGT), on 50th percentile (SGOT, GGT), and on 75th percentile (SGPT, GGT), the alcoholics had higher proportion value of liver marker disturbance than non-alcoholics which was statistically significant (p<0.05). Based on the 50th and 75th percentiles, the alcoholics also had higher proportion value on kidney marker (BUN) damage than non-alcoholics which was statistically significant (p<0.05). There were significant differences in GFR values between males and females (p<0.05), males had kidney cell damage 7.9 times more than females. There was no significant difference in the value of GFR between alcoholics and non-alcoholics. In conclusion, the alcoholics hassignificantly higher proportion value of blood-chemical markers than that non-alcoholics. The GFR values between males and females are also significantly different, and males had kidney cell damage 7.9 times more than that of females.
Universitas Gadjah Mada
Faculty of Medicine UGM
2019-08-20
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/30304
10.19106/JMedSci005103201908
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 246-257
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 246-257
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/30304/pdf
Copyright (c) 2019 S Suhartini, Hendro Widagdo, Yudha Nurhantari, Idha Arfianti Wiraagni
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/30665
2019-08-05T07:20:12Z
bik:ART
Correlation between Toxoplasma gondii and Cytomegalovirus infections and somatic symptom in community
Anindya, Isti
Mulyono, Budi
Marchira, Carla R.
Soesatyo, Marsetyawan HNE
Toxoplasma gondii, Cytomegalovirus,SSI, Somatic Symptom
The prevalence of Toxoplasma gondii and Cytomegalovirus (CMV) infections are high in the world. Indonesia is one of the countries with high prevalence of these infections varied from 20 to 63%. The T. gondii and CMV infections infections can be chronic and cause maternal and fetal deatht as well as infant defects. Previous clinical study reported that chronic infections can cause somatic symptoms indicating psychological stress. The aim of this study was to evaluate the correlation between T. gondii and CMV infections with somatic symptoms. This was an observational study with a cross sectional design involving 103 eligible patients with seropositive IgG T. gondii or and CMV from six cities in Java, Indonesia. The presence of somatic symptoms was detected by using somatic symptoms inventory (SSI) questionnaire. Logistic regression analysis was used to evaluate the correlation. The percentage of patients with somatic symptoms (SSI score >48) in seropositive groups of IgG anti- T. gondii, anti-CMV, anti- T. gondii and CMV were 70.0; 62.2 and 36.2%, respectively. In addition, the prevalence ratio (PR) for each group were 1.333, 1.178, and 0.954, respectively. No significantly different in PR was observed in this study (p>0.05). In conclusion, the T. gondii and CMV infections are not correlted with the somatic symptoms.
Universitas Gadjah Mada
2018-07-23
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/30665
10.19106/JMedSci005001201809
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/30665/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/30665/3261
Copyright (c) 2018 Isti Anindya, Budi Mulyono, Carla R. Marchira, Marsetyawan HNE Soesatyo
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/30921
2019-11-26T06:55:19Z
bik:ART
The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report
Poedjomartono, Bagaswoto
Pramiadi, P
imaging adenocarcinoma colorectal; transcatheter arterial chemoinfusion; unresectable adenocarcinoma colorectal; oxaliplatin; bevacizunab
Colorectal cancer (CRC) is the fourth most common cancer in worldwide. In the last 10 years, the mortality rate of CRC decreased by more than 20% and 5-year survival remains approximately 60% due to the rising developments in diagnostic techniques and optimization of surgical, neoadjuvant and palliative therapies. We reported a case of 80-year-old woman with diarrhea, blood in the stool and weight loss for a year. The patient was diagnosed with colonic polyp eight years ago. In double-contrast barium enema (DCBE) showed filling defects in sigmoid with pedunculated form. Optical colonoscopy demonstrated tumor in sigmoid. Computed tomography (CT) abdomen showed circumferential thickening and luminal narrowing of sigmoid colon with stranding of the serosa and mesenteric fat as well as enlarge pericolic nodes without distant metastasis. Based on American Joint Committee on Cancer criteria the stage was T3N1M0. From histopathological diagnosis, the tumor was well differentiated adenocarcinoma. We concluded as unresectable adenocarcinoma colorectal. Patient received transcatheter arterial chemoinfusion (TACI) with oxaliplatin and bevacizunab in three courses every 2 months. After first TACI, symptoms and patient’s performance status improved without systemic side effects. Arteriography imaging showed decrease in tumor staining after third TACI. CT evaluation showed a significant decrease of tumor size, without nodal and distant metastasis.In this case, TACI treatment with oxaliplatin and bevacizumab in unresectable adenocarcinoma colorectaldemonstrated improvement of patient’s performance status, partial response, decrease stage and symptoms, without systemic side effects. It is proven that TACI treatment may be an effective palliative therapy for unresectable colorectal cancer. Further studies should be performed to verify these findings.We reported a case of a woman with unresectable adenocarcinoma colorectal showed good results after received TACI treatment.
Universitas Gadjah Mada
2019-07-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/30921
10.19106/JMedSci005103201910
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 270-281
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 3 (2019); 270-281
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/30921/pdf
Copyright (c) 2019 Bagaswoto Poedjomartono, P Pramiadi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31079
2020-06-01T06:14:03Z
bik:ART
The potential of meropenem and piperacillin-tazobactam combination to Acinetobacter spp clinical isolates in vitro
Diani, Alindya
Arguni, Eggi
Rizki, Ludhang Pradipta
sepsis; acinetobacter spp; paper strip test; meropenem; piperacillin; tazobactam;
Acinetobacter spp is one of the most common causes of nosocomial infection, especiallysepsis. A lot of antibiotics resistance happen related to Acinetobacter-related sepsis treatment. This study aimed to evaluate the potential of meropenem and piperacillin-tazobactam combination against Acinetobacter spp in in vitro by using paper strip test. This was experimental study conducted in September to December 2015 at Departement of Microbiology, Faculty of Medicine, Public health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical isolates of Acinetobacter samples were obtained from collections of the Department of Microbiology. The data were analyzed using post-test analysis which was conducted by observation over 24 h after the paper strip test was applied in bacterial culture. The MIC value of the antibiotic combination was recorded based on observation. The result showed 12 of 17 clinical isolates were synergistic potential (70.59%) and 5 others were indifferent potential (29.41%). Two of five clinical isolates that show indifferent potential were A. baumannii and all of the clinical isolates that show synergistic potential were Acinetobacter spp. It can be concluded that the combination of meropenem and piperacillin-tazobactam showed more synergistic dominantly than the single use of each of them.
Universitas Gadjah Mada
2020-02-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31079
10.19106/JMedSci005201202001
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 1 (2020)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 1 (2020)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31079/27124
Copyright (c) 2020 Alindya Diani, Eggi Arguni, Ludhang Pradipta Rizki
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31085
2020-06-01T06:13:40Z
bik:ART
The association between malaria incidences and air temperature at Kulon Progo District, Yogyakarta Special Province
Nilasari, .
Lazuardi, Lutfan
malaria; air temperature; spatial analysis; Kulon ProgoDistrict; Yogyakarta;
Malaria is still a public health problem in Indonesia including in Kulon Progo District, Yogyakarta Special Province. Kulon Progo District remains become malaria endemic area, with significant number of malaria cases for more than the last ten years. Previous studies proved that malaria transmission is associated with climatic conditions. However, these conditions have never been investigated in Kulon Progo District. The aim of this ecological study was to investigate the association between the distribution of malaria cases and climatic condition in the Kulon Progo District using spatial-temporal approach. A total of 1439 malaria cases were collected during the period of 2005-2015. Time-trend, bivariate analysis, and spatial analysis were performed. The results showed that air temperature lag 0 (p = 0.0000; r = 0.5225), air temperature lag 1 (p = 0.0009; r = 0.2850), air temperature lag 2 (p = 0.0329; r = 0.1858) related to the incidence of malaria. Spatial analysis and time-trend analysis also showed direct relationship pattern between malaria and air temperature. In conclusion, there is a relationship between malaria cases and air temperature in Kulon Progo District. Spatial analysis approach is important for early alert system, to decrease morbidity and mortality due to malaria.
Universitas Gadjah Mada
LPDP (Institute for the Management of Education Funds), Ministry of Finance, District Health Office of Kulon Progo
Indonesian Agency for Meteorological, Climatological and Geophysics Province of Yogyakarta,etc
2020-05-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31085
10.19106/JMedSci005202202007
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 2 (2020)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 52, No 2 (2020)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31085/pdf
https://jurnal.ugm.ac.id/bik/article/downloadSuppFile/31085/4092
Copyright (c) 2020 . Nilasari, Lutfan Lazuardi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31173
2018-06-19T00:17:00Z
bik:ART
Prevalence and Distribution of Thalassemia Trait Screening
Husna, Nailil
Sanka, Imanuel
Al Arif, Ahmad
Putri, Chintya
Leonard, Elory
Handayani, Niken Satuti Nur
Thalassemia is an inherited disorder of autosomal recessive gene caused by decrease or absent production of one or two type of globin chain. This disorder will affect the quality and quantity of blood production. In Indonesia, thalassemia is not concerned as urgency, although it lies in thalassemia belt area. Thalassemia is classified according to the particular globin chain which affected such as α-thalassemia and β-thalassemia. Besides thalassemia, there are variant hemoglobinopathy called HbE. The aim of this study was to assess the prevalence of thalassemia carriers among the volunteer of screening in province DI Yogyakarta from 2012 until 2015. The thalassemia carrier screening was conducted by collaborating with Indonesian Association of Parents of Children with Thalassemia (POPTI) Yogyakarta. The hematological measurement and High-Performance Liquid Chromatography (HPLC) were performed on Prodia Laboratory Yogyakarta. The analysis of carriers prevalence was conducted in Laboratory of Genetics and Breeding, Faculty of Biology, Universitas Gadjah Mada. From 241 volunteers, we found 44 volunteers was diagnosed as β-thalassemia carrier, 30 volunteers as α-thalassemia carrier as well as HbE disorder carrier, and 1 volunteer was diagnosed as α-β-thalassemia carrier. The number of thalassemia carrier shows no significant difference each year. The prevalence of thalassemia carrier was high, even though the distribution is limited by the location where the screening took place.Keywords : Thalassemia trait screening - α-thalassemia - β-thalassemia – HbE – HPLC
Universitas Gadjah Mada
2017-07-07
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31173
10.19106/10.19106/JMedSci004903201702
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 49, No 3 (2017)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31173/pdf
Copyright (c) 2017 Nailil Husna, Imanuel Sanka, Ahmad Al Arif, Chintya Putri, Elory Leonard, Niken Satuti Nur Handayani
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31254
2019-05-21T07:14:41Z
bik:ART
Neonatal outcomes in In vitro fertilization (IVF) pregnancies
Buchori, Muhammad
Patria, Suryono Yudha
Wibowo, Tunjung
Hanoum, Ita Fauzia
in vitro fertilization – preterm - small for gestational age - low birth weight – relative risk
small-for-gestational age (SGA), and low birth weight (LBW) rates are approximately twiceas high in IVF pregnancies than in natural pregnancies. The IVF procedures have becomemore routine in recent years in Indonesia, but there have been few assessments ofneonatal outcomes. The study aimed to evaluate the risk of preterm birth, SGA, and LBWin IVF infants. This was a retrospective cohort study performed in Dr. Sardjito GeneralHospital, Yogyakarta from January 2012 to December 2016. Pre-coded questionnaireswere used to collect data from medical records. The relative risk of preterm birth, SGA,and LBW among IVF infants were calculated and compared to naturally conceived infants.A total sampling method was used for the IVF infants and a simple random samplingmethod was used for naturally conceived infants, who were born on the same day as aninfant in the IVF group.A total of 108 infants were recruited, consisting of 54 IVF infants and 54 naturallyconceived infants. The IVF infants had increased risk of preterm birth (RR = 2.0; 95%CI0.52 - 7.58) and LBW (RR = 1.25; 95%CI 0.53 - 2.92). However, the IVF infants didnot have an increased risk of SGA (RR = 1.0; 95%CI 0.21 - 4.73). In conclusion, therisk of preterm birth and LBW in IVF infants are higher than in naturally conceived infants,but not statistically significant. However, there is no increased risk of SGA in IVF infants.
Universitas Gadjah Mada
2018-10-09
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31254
10.19106/JMedSci005002201805
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31254/pdf
Copyright (c) 2018 Muhammad Buchori, Suryono Yudha Patria, Tunjung Wibowo, Ita Fauzia Hanoum
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31553
2019-05-21T07:16:55Z
bik:ART
The Impact of Malaria in Pregnancy on Infant Susceptibility to Malaria Infection
Indrawanti, Ratni
Wijayanti, Mahardika
Hakimi, Mochamad
Juffrie, Mohammad
Kenangalem, Enny
Burdam, Faustina Helena
Triyanti, Leily
Noviyanti, Rintis
Syafruddin, Din
Ahmed, Rukhsana
ter Kuile, Feiko
Poespoprojo, Jeanne Rini
Malaria - pregnancy - infant susceptibility - Timika Papua – risk factors
Malaria infection during pregnancy is a significant global health problem with substantialrisks for pregnant women, her foetus, and the newborn child. Infant malaria is a majorpublic health concern in Timika, Papua. The aim of the study was to investigate the impactof malaria during pregnancy on infant’s susceptibility to malaria infections, the timing ofits occurrence, the number of malaria infections during pregnancy. This was a cohortprospective study conducted in Timika, Papua from October 2013 to September 2016.Malaria investigation was done by microscopic and PCR methods. Demographic data andmalaria status of mother-infant pairs were collected and analyzed by SPSS 22.0 version.One hundred seventy-eight infants consisting of 95 (53.37%) infants born to motherswith malaria and 83 (46.63%) without malaria 91 (51.12%) boys and 87 (48.88%) girlswere involved in the study. The mean of mothers’ ages were 25.35 ± 6.30 vs. 26.0 ±5.69 years. At the ages of 6 and 12 months, infants born to malaria positive motherswere more susceptible to malaria infections compared to infants born to malaria negativemothers with RR = 3.49; 95%CI: 1.02-11.96; p = 0.03 and RR = 8.74; 95%CI: 1.14-66.81; p = 0.01, respectively. Independent risk factors of infant susceptibility to malariainfection during the first year of life were malaria in pregnancy (MiP) in 2nd trimester (RR= 4.50; 95%CI: 1.5-13.49; p = 0.07), pregnant women who only got malaria infection1 time during pregnancy (RR=2.95; 95%CI: 1.04-8.33; p = 0.04), and Papuan ethnicity(RR=3.58; 95%CI: 1.22-10.59; p = 0.02). In conclusion, infant susceptibility to malariais associated with maternal malaria status during pregnancy. MiP in second trimester,pregnant women who only had malaria once and Papuan ethnicity were independent riskfactors for infant’s increased susceptibility to malaria infection.
Universitas Gadjah Mada
2018-04-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31553
10.19106/JMedSci005002201807
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31553/pdf
Copyright (c) 2018 Ratni Indrawanti, Mahardika Wijayanti, Mochamad Hakimi, Mohammad Juffrie, Enny Kenangalem, Faustina Helena Burdam, Leily Triyanti, Rintis Noviyanti, Din Syafruddin, Rukhsana Ahmed, Feiko ter Kuile, Jeanne Rini Poespoprojo
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31586
2018-07-26T06:18:52Z
bik:ART
S. epidermidis : how to turn from commensal to be a pathogen lifestyle
Nuryastuti, Titik
Staphylococcus epidermidis; commensal; pathogen; virulence factor; biofilm
Staphylococcus epidermidis normally is a commensal inhabitant of healthy human skin and mucosa, but also a common nosocomial pathogen in immunocompromised patients, neonates, and patients with indwelling medical devices. To distinguish the pathogen and commensal strain is a big challenge when identifying this agent with its related infection. This mini-review aims to summarize recent research in this area with a special emphasis on the virulence factor of generating genotypic and phenotypic diversity in S. epidermidis.By living between a commensal and pathogen, S. epidermidis needed to establish many strategies to face different clinical environments, including the new ecological niche of biomaterials. In addition, the growing number of immunocompromised patients increased the risk for a very sensitive host. However, further exploration of the relationship between virulence factor and in vivo pathogenesis is still needed. According to the virulence factor of these bacteria, which are considered as a real pathogen, strict control measures should be taken for S. epidermidis infection.
Universitas Gadjah Mada
2018-04-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31586
10.19106/JMedSci005001201813
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31586/pdf
Copyright (c) 2018 Titik Nuryastuti
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31714
2018-08-01T07:20:03Z
bik:ART
Surgical Management for Resistant Gestational Throphoblastic Neoplasia: Yogyakarta Experience
Gulo, Greta S
Darmawan, Nirwan
Irsan, Bob
Prabowo, Wisnu
Kusumanto, Ardhanu
chemotherapy. hysterectomy. gestational trophoblastic neoplasia. GTN
Gestational trophoblastic neoplasia (GTN) is a highly responsive to chemotherapy, but sometimes can be resistant, or relapse and require salvage chemotherapy with or without surgery. We use descriptive studies with case series to determine prognosis patient GTN with chemotherapy resistant manage with surgical procedure in Sardjito Hospital, Yogyakarta. GTN-resistant chemotherapy patients that undergoing hysterectomy showed significant decreases in hCG levels. Hysterectomy also help us to stop vaginal bleeding. However, complications from continuous bleeding can worsen patient condition. The decision to take a hysterectomy action varies depending on the patient's condition. At the Sardjito hospital, the patient was diagnosed with the fastest hysterectomy within the first 12 hours of treatment due to continuous bleeding, and shortly after 4 years of treatment with 5 different types of chemotherapy.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31714
10.19106/JMedScieSup005001201803
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31714/pdf
Copyright (c) 2018 Greta S Gulo, Nirwan Darmawan, Bob Irsan, Wisnu Prabowo, Ardhanu Kusumanto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31905
2018-08-01T07:20:03Z
bik:ART
Relationship Factors Physical Environment and Behavior house Respondents with incidence of Dengue Hemorrhagic Fever in Depok 2016
Ranggauni, Fathinah
Kiptiyah, Nuning Maria
Dengue, Home Physical Environment, Public Behavior
AbstractDepok City is one of the endemic areas of dengue disease in Indonesia. An increase and spread of dengue cases was likely caused by the high mobility of the population, urban development, climate change, changes in population density and distribution. This research is an analytic study with case control design. This study found that in bivariate analysis, the variables associated with the incidence of dengue in the city of Depok are variable lighting (OR = 2.857, 95% CI = 1.179 to 7.175), variable cleaning TPA (OR = 2.210, 95% CI = 0.972 to 5.103), variable educational level (OR = 24.375 (95% CI = 3.540 to 1030.606). On multivariate analysis, the home environment variables that individuals with home lighting ineligible risk of 3.369 (95% CI: 1.418 to 8.005) compared to individuals exposed to dengue home lighting qualify as controlled by confounding variables, namely the habit of cleaning water reservoirs and jobs. On multivariate analysis, behavioral variables respondent is an individual who cleans water reservoirs are not routinely <1 time a week are at risk of 3.293 (95% CI: 1.321 to 8.212) DHF compared with individuals who have the habit of cleaning water reservoirs regularly after confounding variables are controlled by environmental conditions and education of home lighting. For Depok City Health Department inspection home lighting conditions and larvae regularly, fogging and improve health promotion to respondents on how to prevent dengue by conducting 3M plus especially on variable bathtub drain in order to suppress the incidence of dengue in the working area. For respondents in order to join and participate in efforts to Mosquito Nest Eradication of Dengue Hemorrhagic Fever (PSN-DBD).
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31905
10.19106/JMedScieSup005001201802
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31905/pdf
Copyright (c) 2018 Fathinah Ranggauni, Nuning Maria Kiptiyah
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31908
2018-08-01T07:20:03Z
bik:ART
LDL/HDL ratio association with out-patient NIHSS score and Dyslipidemic Drug intake status as Metabolic Syndrome Criteria of ischemic stroke patients at RSUP Dr. Sardjito, Yogyakarta
Elberta, Felicia
Ghofir, Abdul
Rusdi, Imam
HDL/LDL ratio, NIHSS, ischemic stroke, cut off point, dyslipidemic drug status
LDL-C/HDL-C ratio (numeric) is a more significant predictor of the progression of IMT than LDL-C or HDL-C alone (2). The Objective is to check whether being dyslipidemic or metabolic syndrome shown by the ratio, affects the data of NIHSS results obtained to measure functional outcome. the data was analyzed using Pearson Chi-square with contingency table post-hoc analysis and Spearmann’s Correlation with additional simple-linear regression.Out of 189 subjects, only 156 data are complete and valid. 70 patients were dyslipidemic, 65 were non-dyslipidemic and the rest were unknown. There is a significant association of LDL/HDL ratio cut off point above 2,3 with dyslipidemic drug intake likely to produce a mild NIHSS outcome category (z score 2,1) (calculator is P value = 0,035729), but not with other NIHSS categories. There is significant association of patients that do not take dyslipidemic drug with whatever LDL/HDL cut off point to the predictor outcome of Mild NIHSS category, but not with other NIHSS categories. The correlations are also insignificant between the LDL/HDL ratio and NIHSS score in one tailed (p<0,36) and at two tailed (p<0,72).Moreover, simple linear regression reveal that LDL/HDL ratio predicts 16% of NIHSS score, while taking anti dyslipidemic drugs which mean the person is dyslipidemic, and LDL/HDL ratio predict 31% of NIHSS outcome. Therefore LDL/HDL ratio have weak predictor value to NIHSS outcome, should not be an independent predictor.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31908
10.19106/JMedScieSup005001201804
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31908/pdf
Copyright (c) 2018 Felicia Elberta, Abdul Ghofir, Imam Rusdi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31909
2018-08-01T07:20:03Z
bik:ART
Coronary Artery Calcium Score Improved Cardiovascular Disease Risk Prediction in Asymptomatic Patients
Wirawan, I Md Ady
Wu, Rodney
Abernethy, Malcolm
Aldington, Sarah
Larsen, Peter
: assessment tool, CACS, Framingham risk score, asymptomatic people, risk stratification
This study examined whether coronary artery calcium score (CACS) has a betteraccuracy than the cardiovascular risk prediction chart (CRPC), and evaluate thereclassification improvement of CACS if it isused as a screening tool compared withthe CRPC. CACS has a better accuracy than the CRPC and reclassified a considerableproportion (39%) of a symptomatic patient into correct cardiovascular risk categories.CACS should be assessed in asymptomatic people with5-year CVD risk score of5-10% and 10-15%.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31909
10.19106/JMedScieSup005001201805
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31909/pdf
Copyright (c) 2018 I Md Ady Wirawan, Rodney Wu, Malcolm Abernethy, Sarah Aldington, Peter Larsen
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31923
2018-08-01T07:20:03Z
bik:ART
Cervical cancer screening coverage in urban and rural areas: its determinants
Saimin, Juminten
Wicaksono, Satrio
Ashaeryanto, .
distance of service facilities, education, knowledge, VIA
Cervical cancer is a woman’s health problem that is still widespread throughtout the world, especially in developing country such as Indonesia. The high incidence of cervical cancer related with early detection program. Visual inspection of acetic acid (VIA) is used as an alternative screening method because it is easier, cheaper and effectiveness is not much different from the Pap test. The most participant in urban and rural areas was the age group 31-40 years old, low parity, and first intercourse at ≥ 17 years old. There was asscociation between cervical cancer screening coverage with education level, knowledge and distance of service facilities. There were significant difference of education level (p = 0.000), knowledge (p = 0.000) and distance of service facilities of urban and rural participant (p = 0.000). There was no significant differences in family support of urban and rural participant (p = 0.224).
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31923
10.19106/JMedScieSup005001201806
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31923/pdf
Copyright (c) 2018 Juminten Saimin, Satrio Wicaksono, . Ashaeryanto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31924
2018-08-01T07:20:03Z
bik:ART
Trends of Rotavirus Diarrhea in Hospitalized Children in Yogyakarta Year 2013 –2015
Mulyani, Nenny Sri
Anggraini, Dian
Baroto, Retno Palupi
Erlin Mulyadi, Asal Wahyuni
Anindita, Rizki
Soenarto, Yati
rotavirus diarrhea, vaccine, children under five, Indonesia
Diarrhea, together with pneumonia, is accountable for 25% death of children under five globally (IVAC, 2017). In Indonesia, diarrhea is also among the top ten diseases of cause of death in children under five (WHO, 2015). Rotavirus diarrhea is responsible for 60% in 2006 (Soenarto et al, 2009) of children diarrhea in Indonesia. Rotavirus vaccine in Indonesia was introduced commercially in 2011, nonetheless its use was reportedly low. Despite the declining rate of rotavirus incidence, surveillance is important to show the burden of rotavirus diarrhea in children. Thus, this study aims to describe the incidence of rotavirus diarrhea in hospitalized children under five in Yogyakarta province. This was a prospective study, conducted in two participating hospitals in Yogyakarta: RSUP Sardjito Yogyakarta and RSUD Wates from January 2013 – December 2015. This study is a part of the Indonesia surveilance entitled “Hospital-based surveillance of rotavirus diarrhea in children in Indonesia”, enrolling children under five hospitalized due to acute watery diarrhea. The questionare was modified from the WHO generic protocol of rotavirus surveillance (WHO, 2002). Data collection was perfomed after informed consent was signed by parent or guardian. The stool samples were tested for rotavirus with the EIA test and tested for genotyping with RT-PCR. The data were analysed and presented using descriptive analytic method. Of 684 eligible patients hospitalized with acute watery diarrhea, 557 subjects were enrolled with 518 feces were tested for rotavirus. The percentage of rotavirus incidence in year 2013, 2014, and 2015 were 37%, 41% and 61 % respectively. The predominant rotavirus genotyping was G3P [8]. Rotavirus mostly found in children age 6 – 23 months (55 %), and was identified more in male than female (62 % vs 38%). During the 3 years study period, rotavirus occurred all year round, and showed to reach its peak on January 2015. Rotavirus positive diarrhea commonly presented with dehydration (79%) compare to negative rotavirus diarrhea (55%). It indicated that the incidence rate of rotavirus diarrhea in Yogyakarta is quite high and rotavirus diarrhea remains as significant contributor to hospitalized children with diarrhea. The trend of rotavirus diarrhea in children under 5 years increased over the years’ period. The rotavirus diarrhea mostly presented with dehydration, thus rotavirus diarrhea remains as significant contributor to hospitalized children with diarrhea. This shows an evidence that the burden of rotavirus diarrhea in children under 5 years remains prominent.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31924
10.19106/JMedScieSup005001201807
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31924/pdf
Copyright (c) 2018 Nenny Sri Mulyani, Dian Anggraini, Retno Palupi Baroto, Asal Wahyuni Erlin Mulyadi, Rizki Anindita, Yati Soenarto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31928
2018-08-01T07:20:03Z
bik:ART
Food poisoning at a Javanese wedding tradition at Wirogunan Building on July 23rd 2017
Prihastuti, Rieski
Depo, Meliana
Wibowo, Trisno Agung
Misinem, .
outbreak, food poisoning
suspected food poisoning outbreak of 5 cases was reported from Mergangsan primary health care to the Yogyakarta Health Office on July 24th 2017. Objective of this study were to ensure food poisoning outbreak and identify source and route of transmission. A total of 166 respondent was included. All of 83 cases got diarrhea. Epidemic curve showed a common source with incubation period 1-23,5 hours and median incubation was 12 hours. Based on its clinical symptoms and incubation period, this outbreak suspected caused by S.aureus contamination. Statistical analysis showed that the greatest attack rate ratio and odds ratio was found in rendang (AR 3,15 and OR 6,6135; 95% CI 2,7812-16,874). Limitation of this study was there were no sample of food/feces/vomit to confirm the agent.
Universitas Gadjah Mada
Lembaga Pengelola Dana Pendidikan (LPDP)
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31928
10.19106/JMedScieSup005001201809
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31928/pdf
Copyright (c) 2018 Rieski Prihastuti, Meliana Depo, Trisno Agung Wibowo, . Misinem
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31933
2018-08-01T07:20:03Z
bik:ART
Child tuberculosis in Respira Lung Hospital, Yogyakarta: demographic and clinical profiles
Firmanti, Stefani Candra
Triasih, Rina
children, tuberculosis, clinical, demographic
Tuberculosis (TB) remains a significant source of morbidity and mortality among children in endemic settings. Demografic and clinical profiles of children with TB in Yogyakarta have not been well documented. A total of 80 children with TB were diagnosed with TB during the study period. There were 41 (51.2%) females and 39 (48.8%) males. The case findings of child TB cases has been increasing from 20 cases in 2014, 28 cases in 2015, and 32 cases in 2016. The majority of the children (89.3%) aged less than 5 years. The most common symptoms were cough 50 (62.5%), followed by weight loss 45 (56.3%), and fever 28 (35%). Contact with a TB case was identified in 46 (57.5%) children. Mantoux test was done in 76 (95%) children with positive result documented in 61(76.3%) children. Chest X-ray was done in 54 (67.5%) children, of which 52 (65%) chest X- rays showed suggestive of TB. Confirmed diagnosis (bacteriology) was only documented in one child (1.25%).
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31933
10.19106/JMedScieSup0050012018010
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31933/pdf
Copyright (c) 2018 Stefani Candra Firmanti, Rina Triasih
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31934
2018-08-01T07:20:03Z
bik:ART
AAssociation between migraine and ischaemic stroke in Prof. Dr. Margono Soekarjo Hospital, Purwokerto, Indonesia
Razanah, Yahdiyani
Migraine, Ischaemic Stroke
Headache especially the migraine type has been correlated with various disease, such as stroke. There are some controversies in studies that reported association between migraine and ischaemic stroke. Thus, study that investigate the association between migrain – stroke andalso identify stroke risk factor are needed. Study showed there is no statistically significant relationship between migraine and ischaemic stroke in RSUD Prof. Dr. Margono Soekarjo Purwokerto (p=0,235). Analysis of confounding variables such as hypertension, smoking, diabetes, obesity, alcohol consumption, and oral contraceptive shows that hypertension is a predictor for stroke.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31934
10.19106/JMedScieSup0050012018011
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31934/pdf
Copyright (c) 2018 Yahdiyani Razanah
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31935
2018-08-01T07:20:03Z
bik:ART
Onset to Hospital Admission Time and Disability in Patients with Ischemic Stroke
Dharmawan, Andre
Pinzon, Rizaldy Taslim
ischemic stroke, onset to admission time, disability
The predictive factors of disability in stroke patients are still varied and subject to debate. Lower onset to admission time has been known produces excellent outcomes with significantly lower rates of morbidity and mortality. Previous study about the onset admission time in patients with stroke ischemic in Indonesia is very limited. This was a retrospective cohort study using secondary data from electronic medical record and electronic stroke registry of Bethesda Hospital Yogyakarta Indonesia. A total of 1657 patients with ischemic stroke was admitted between 2015-2017 and 313 patients were included in this study adjusted by inclusion and exclusion criteria. Factors such as age, gender, onset, previous stroke, comorbidities and complications were assessed. Multiple logistic regression analysis showed onset > 6 hour (RR: 4.567; 95% CI: 2.372-8.792;p: 0.000), age (RR: 2.366; 95% CI: 1.357-4.125;p:0.002) and patients with complications (RR: 12.403; 95% CI:2.443-62.968;p:0.002) were independently significant increasing the risk of disability in patient with ischemic stroke. Onset to hospital admission time > 6 hour was significantly increasing disability on ischemic stroke patients. Giving treatment less than 6 hours could save the patient from disability.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31935
10.19106/JMedScieSup0050012018012
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31935/pdf
Copyright (c) 2018 Andre Dharmawan, Rizaldy Taslim Pinzon
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31946
2018-08-01T07:20:03Z
bik:ART
Risk Factors for Acute Otitis Media in Children at Dr.Soedono Hospital
Abror, Jeem Yaltafit
Novita, Andriani Russy
Slamet, Suwondo
Acute otitis media, children, risk factor
Acute otitis media (OMA) was the most common ear infection in children. Because of Tuba Eustachius was not developed yet, shorter and flatter / horizontal in children so the secretions of nasopharynx were easier to enter the middle ear. OMA can cause many complications such as subperiosteal abscess to severe complications like meningitis and brain abscess. Epidemiological studies of OMA in developing countries were still rare. The prevalence of OMA was different in many country, ranging from 2.3 - 20%. The result of study showed that the prevalence of OMA in children in East Jakarta was 5.38%, and the highest prevalence was on group among 2-5 years old. 179 patients analyzed were 50.8% male and 49.2% female. The mean age of this study subjects was 4.75 years (SD 4.54). 31.3% were diagnosed with OMA. There was no difference in the location of the OMA occurrence between the right and left ear. There was a significant correlation between age factor and the incidence of OMA (p = 0.014) and subjects which under 5 years of old became a risk factor for OMA. The results also showed that there was a correlation between treatment and the incidence of OMA (p = 0.000), ARI patients without treatment was being a risk factor for the incidence of OMA in children. There was no correlation between sex, type factor and health insurance against the occurrence of OMA.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31946
10.19106/JMedScieSup0050012018013
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31946/pdf
Copyright (c) 2018 Jeem Yaltafit Abror, Andriani Russy Novita, Suwondo Slamet
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31983
2018-08-01T07:20:03Z
bik:ART
The quality of live of patients’ allegic rhinitis after posterior nasal neurectomy at Dr Sardjito General Hospital Yogyakarta, Indonesia 2016
Kusdaryanto, Wahyu Dwi
Isminarsih, Windarti
Indrawati, Luh Putu Lusy
Allergic Rhinitis (AR), SNOT-20, Posterior Nasal Neurectomy
Allergic rhinitis (AR) is disease by incidence and prevalence of high and is expected to rise to load against the economy and lowering the quality of life of patients.with AR involved many factors and an impact of highly significant on the quality of life and affect the economy. The quality of life patients done to assess the effects and result of surgery.Sino nasal outcome test-20 ( snot-20 ) was one of the instruments specific measurement the quality of life of patients AR. 10 patients who surgery action , obtained improving the quality of life based on snot- 20 observed 28 days after done the act of surgery. Rate the SNOT-20 before surgically obtained 37,3 with DS ± 7,87 and 28 days after done surgically obtained rata-rata snot-20 is 6 with DS ± 2,49. The SNOT-20 pre and post action there are different of significant (p = 0,024 ) .
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31983
10.19106/JMedScieSup0050012018014
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31983/pdf
Copyright (c) 2018 Wahyu Dwi Kusdaryanto, Windarti Isminarsih, Luh Putu Lusy Indrawati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31985
2018-08-01T07:20:03Z
bik:ART
The quality of patients chronic rhinosinusitis after functional endoscopicsinus surgery at Dr Sardjito General Hospital, Yogyakarta, Indonesia
Kusdaryanto, Wahyu Dwi
Isminarsih, Windarti
Indrawati, Luh Putu Lusy
Chronic Rhinosinusitis, SNOT-20, Functional Endoscopic Sinus
Chronic Rhinosinusitis (CR) is disease by incidence and prevalence of high and is expected to rise to load against the economy and lowering the quality of life of patients.with CR involved many factors and an impact of highly significant on the quality of life and affect the economy.The quality of life patients done to assess the effects and result of surgery.Sino nasal outcome test-20 ( snot-20 ) was one of the instruments specific measurement the quality of life of patients CR. 10 patients who surgery action , obtained improving the quality of life based on snot-20 observed 28 days after done the act of surgery. Rate the SNOT- 20 before surgically obtained 37,3 with DS ± 7,87 and 28 days after done surgically obtained rata-rata snot-20 is 6 with DS ± 2,49. The SNOT-20 pre and post action there are different of significant (p = 0,024 ) .
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31985
10.19106/JMedScieSup0050012018015
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31985/pdf
Copyright (c) 2018 Wahyu Dwi Kusdaryanto, Windarti Isminarsih, Luh Putu Lusy Indrawati
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31987
2018-08-01T07:20:03Z
bik:ART
Immunohistochemical Profile Of Breast Cancer Patients On Oncology Department, Moewardi Hospital, Surakarta, Indonesia
Wahid, Dian Ibnu
Yarsa, Kristanto Yuli
Immunohistochemical profile, breast cancer
Immunohistochemical is used to show hormone receptors on their surface. The aim of this study were to find information about immunohistochemical profile of breast cancer patient on oncology department, Moewardi Hospital, Surakarta Indonesia. A total 1.395 cases of breast carcinoma with Her2 profile were reviewed. The mean age of the patients was 45.7 (Ranged 23-73 years old). At time of diagnosis 739 (53%) patients were under 50 years of age. In this group the frequency of Her2 positive was higher than other. The incidence of patients above 50 years of age were significancy higher in Her2 positive with 363 (47%). Ductal invasive carcinoma is the most common type of breast carcinoma (86.9%). HER-2 Positive subtype was the most common subtype in the woman breast carcinoma (43.6%), which was followed by Basal like (31.3%), Luminal A (16.8%) and (8.3%). For tumor grading, the highest on G3 with the results 764 (54.7%). G3 got the highest results on Her2 positive with 535. We just divide the type of tumor consist of three parts (ductal, lobular, and other). In tumor type obtained the most data on ductal carcinoma with 878 (63%).
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31987
10.19106/JMedScieSup0050012018016
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31987/pdf
Copyright (c) 2018 Dian Ibnu Wahid, Kristanto Yuli Yarsa
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31990
2018-08-01T07:20:03Z
bik:ART
Epidemiological Correlation Between Her-2 Expression With Histological Type and Grade Breast Carcinoma On Oncology Department, Moewardi Hospital, Surakarta, Indonesia
Wahid, Dian Ibnu
Soewoto, Widyanti
Her-2 expression, hystological type, grade, breast carcinoma
Some woman have breast tumors with higher level of HER-2. HER-2 receptor is is a member of the epidermal growth factor receptor family which one such gene that can play a role in the development of breast carcinoma. Normally, HER-2 receptors control breast cell grows, divides, and repair breast cell. But in pathologic conditions it make too many copies. The aim of this study was to evaluated the expression of HER-2 in woman breast carcinoma and to compare it with Histological Type and Grade. We Observed 1.395 patients with breast carcinoma. The mean age of the patients was 45.7 (Ranged 23-73 years). In this group the frequency of Her2 positive was higher than other. The incidence of patients above 50 years of age were significancy higher in Her2 positive with 363 (47%). For tumor grading, the highest on G3 with the results 764 (54.7%). G3 got the highest results on Her2 positive with 535. We just divide the type of tumor consist of three parts (ductal, lobular, and other). In tumor type obtained the most data on ductal carcinoma with 878 (63%). The difference did not achieve stastitical significance , when calculated with chi square got results >0.05. From the results can be concluded there is no relationship between Her2 with histological type and grade breast cancer.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31990
10.19106/JMedScieSup0050012018017
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31990/pdf
Copyright (c) 2018 Dian Ibnu Wahid, Widyanti Soewoto
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/31992
2018-08-01T07:20:03Z
bik:ART
Comparison of Quality of Life For Breast Conserving Surgery And Mastectomy In Early Stage Breast Cancer In Breast Cancer Survivors Community
Wahid, Dian Ibnu
Yarsa, Kristanto Yuli
Quality of life, breast cancer, breast conserving surgery, mastectomy, early stage
Breast cancer surgery can impact patients psychologically as well as organically, which can manifest as Quality of life (QOL). Thirty patients, the age ranged between 25 and 60 years and the mean age 41 years. Twenty seven patients have married, a widow, and two unmarried. There was not found a difference in health related quality of life. No differences were seen in level of pain, skin sensitivity and related problems in surgical area. Woman in mastectomy group reported stastitically more problem with their body image. Beyond that, they also have a complaint about the feelings of sexual attractiveness than woman in breast conserving surgery (BCS). Women undergoing breast conserving surgery experience more positive outcomes than women undergoing mastectomy. Women in the mastectomy groups also reported experiencing more physical problems related to their surgery. The score of CES-D is above 16 both breast conserving surgery’s group and mastectomy’s groups. Higher scores are associated with more symptoms. There were also no differences seen among them as measured by the MOS, four main poins consists of emotional support, real support, affection support and good social interactions. There were also no differences seen among them as measured by the RDAS consists of three aspects (concensus, satisfaction, cohession). This can happen because the doctors give well support and education to all patients. Despite, the patients, their families, their partners also give support each other. The women sight of their body images was considered making well social interaction. Most of the study showed the declining of social interactions after the surgery. This happened beacuse they were apprehensive about rejection in social life.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/31992
10.19106/JMedScieSup0050012018018
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/31992/pdf
Copyright (c) 2018 Dian Ibnu Wahid, Kristanto Yuli Yarsa
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/32021
2018-08-01T07:20:03Z
bik:ART
Expression of Tumor Necrosis Factor - α (TNF-α) and Interleukin 1-β (IL1-β) in Chronic Tubotympanic Suppurative Otitis Media
Darmawan, Anton Budhi
Soesatyo, Marsetyawan HNE
Restuti, Ratna Dwi
Surono, Agus
Chronic Tubotympanic Suppurative Otitis Media, Tumor Necrosis Factor-α, Interleukin 1-β
Chronic Suppurative Otitis Media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment. It is also one of the neglected disease especially in developing countries. Cytokines are a group of glycoproteins that play a role in strengthening the immune and inflammatory reactions in various diseases, including inflammation of the middle ear. Some of the important inflammatory mediators found in middle ear fluids are Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β). Cytokines are thought to play a role in the ongoing inflammatory regulation. The aim of this study was to compare the expression of TNF-α and IL-1β in tubotympanic CSOM and in healthy control group. The mean of TNF-α serum level in tubotympanic CSOM was 0,553±1,59 pg/ ml, and 0,587±2,13 pg/ ml in control group. There was no statistically different of TNF-α between two groups (P > 0,05). Mean of IL-1β serum level in the tubotympanic CSOM and control group were 0,633±0,92 and 0,302±0,48, respectively. Although IL-1β levels were higher in the patient group, the difference was not statistically significant (P > 0,05).
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/32021
10.19106/JMedScieSup0050012018020
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/32021/pdf
Copyright (c) 2018 Anton Budhi Darmawan, Marsetyawan HNE Soesatyo, Ratna Dwi Restuti, Agus Surono
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/32022
2018-08-01T07:20:03Z
bik:ART
Effectiveness of Pyridoxin in Reducing Symptoms of Anxiety Pre Menstrual Syndrome in Adolescent
Nurunniyah, Siti
Nurinda, Eva
Pre Menstrual Syndrome (PMS), Pyridoxin, PMS Type A
Pre Menstrual Syndrome (PMS) affects women’s quality of life, social and economic performance. The other study discovered that 23- 31 % of reproductive aged women experience PMS to a degree that affects their daily acivity Symptoms of Pre Menstrual Syndrome (PMS) are divided into 4 types, namely type A for Anxiety (Anxiety), type C for Craving (Hungry), type D for Depression and Type H for Hyperhydration (Liquid Stockpiling). Type A is commonly unrecognnized in indonesia. Symptoms of type A consist of anxiety, irritability, labilty and nerves tense. So it is important to know how to reduce the symptoms This study aims to determine the effectiveness of pyridoxin in reducing symptoms of Pre Menstrual Syndrome (PMS) and type of symptoms that can be most resolved. There is an effect of using pyridoxine to reduce PMS. It is known from the significance value of t-test that is 0.000. The type of PMS with the highest symptom reduction is in PMS Type A (Anxiety), because pyridoxine can increase stability estrogen and progesterone activity. Anxiety Pre Menstrual Syndrome probably caused by unstable hormone.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/32022
10.19106/JMedScieSup0050012018021
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/32022/pdf
Copyright (c) 2018 Siti Nurunniyah, Eva Nurinda
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/32152
2018-08-01T07:20:03Z
bik:ART
Risk Factors of Malaria Incidence in Endemic Area of Central Java
Mahkota, Renti
Nurcandra, Fajaria
Anggraini, Fitria Dewi Puspita
Putri, Annisa Ika
Wispriyono, Bambang
Malaria incidence, risk factor, endemic area
Malaria caused 212 million cases worldwide in 2015 which associated to environmental factors, ecology, and the presence of vectors. Annual paracite incidence (API) in Indonesia in 2011-2015 decreased. Unfortunately, malaria incidence always exist in Purworejo District which known as one of endemic area in Central Java. This research aimed to determine risk factors of malaria incidence in endemic area especially in Purworejo, Central Java. Logistc regression showed that period of residency 19-34 years (OR=1.612; 95% CI 0.853-3.046), period of residency >34 years (OR=2.050; 95% CI 1.036-4.060), male (OR=2.349; 95% CI 1.365-4.043), and education level less than junior high school (OR=1.677; 95% CI 0.976-2.882) as contributing risk factor to malaria incidence in Purworejo District.
Universitas Gadjah Mada
2018-03-24
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/32152
10.19106/JMedScieSup005001201808
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 1 (2018): SUPPLEMENT
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/32152/pdf
Copyright (c) 2018 Renti Mahkota, Fajaria Nurcandra, Fitria Dewi Puspita Anggraini, Annisa Ika Putri, Bambang Wispriyono
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/32213
2019-05-21T07:23:30Z
bik:ART
The correlation between occurrence of dental caries and oral health-related quality of life (OHRQoL) of elderly population in Yogyakarta Special Region
Agustina, Dewi
Hanindriyo, L
Widita, E
Widyaningrum, R
dental caries - DMFT index – oral health – elderly – quality life
Dental caries is the most common oral disease affecting humans. Based on the Indonesia Basic Health Research (Riskesdas) 2013, prevalence of dental caries in 2013 increased up to 53.2% from 43.4% in 2007. One of the two most increasing prevalence occurred in population of more than 65 years. This disease might affect oral health-related quality of life (OHRQoL) since it causes pain, physical and psychological discomfort. The aim of the study was to evaluate the correlation between occurrence of dental caries and OHRQoL in elderly population in Yogyakarta Special Region. One hundred and eighteen people aged 60 – 80 years consisting 73 female and 45 male involved in the study. The occurrence of dental caries and OHRQoL were determined using decay-missing-filling teeth (DMFT) index, whereas geriatric oral health assessment index (GOHAI) instruments, respectively. The data then were classified into very low, low, moderate and high DMFT and low, moderate and high GOHAI. Spearman’s rank correlation test was conducted to determine correlation between occurrence of dental caries and OHRQoL. Mean scores ofDMFT index and GOHAI were 16.61 ± 7.16 and 47.97 ± 9.03, respectively. Very low, low, moderate, and high DMFT index were experienced by 4 (3.38%), 13 (11.02%), 25 (21.19%) and 76 (64.41%) of 118 elderly, respectively. Low, moderate and high GOHAI were experienced by 71 (60.17%), 25 (21.19%) and 22 (18.64%) of 118 elderly, respectively. Spearman’s rank correlation test showed that the correlation coefficient (r) was -0.263 (p=0.004). There is a negative moderate significant correlation between the occurrence of dental caries and OHRQoL of elderly population in Yogyakarta Special Region.
Universitas Gadjah Mada
2018-04-10
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/32213
10.19106/JMedSci005002201808
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 2 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/32213/pdf
Copyright (c) 2018 Dewi Agustina, L Hanindriyo, E Widita, R Widyaningrum
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/32342
2019-08-08T05:40:18Z
bik:ART
The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
Asnindari, Lutfi Nurdian
Soejono, Sri Kadarsih
Hariyadi, .
physical exercise - serum estrogen - estrogen β receptor - fibroblast - dermis - epidermis.
The decline of estrogen level causes various skin changes including amount of fibroblast, the thickness of epidermis and dermis. Physical exercise is believed can increase the estrogen level and give benefit impacts on skin. It mechanism is often associated with the increase of extragonadal aromatization and estrogen serum, the activation of insulin-like growth factor (IGF), and the expression of estrogen receptor (ER). This study was conducted to investigate the effect of physical exercise in ovariectomized rat on the amount of fibroblast, the thickness of epidermis and dermis, the levels of ER β in skin and serum estrogen. Eight female Sprague Dawley rats aged 3 months were used in this study. Rats were divided into two groups i.e. Group 1 consisted of ovariectomized rats without physical exercise and Group 2 consisted of ovariectomized rats and given measurable and regular physical exercise. Rats ran on treadmill with the speed 18 m/min, the tilt of 5%, duration for 60 min/experiment/day, 5 times a week for 12 weeks. The amount of fibroblast, the thickness of epidermis and dermis, the levels of ERβ in skin and serum estrogen were measured after physical exercise. The result showed that there was a significant difference amount of fibroblast between group 1 and group 2 (p<0.05). However, no significant difference the levels of serum estrogen, ERβ, and the thickness of epidermis and dermis between Group 1 and Group 2 (p>0.05). There was a significant positive correlation between the level of serum estrogen and the thickness of epidermis (p<0.05), and negative correlation between the serum estrogen level and the level of ERβ (p<0.05), and negative significant correlation between the level of ERβ and the thickness of epidermis (p<0.05). In conclusion, the amount of dermal fibroblast of ovariectomized rats increase after underwent measurable and regular exercise. There is correlation between the serum estrogen level and the thickness of epidermis as well as ERβ.
Universitas Gadjah Mada
2018-10-05
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/32342
10.19106/JMedScie/005003201803
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 50, No 3 (2018)
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/32342/pdf
Copyright (c) 2018 Lutfi Nurdian Asnindari, Sri Kadarsih Soejono, . Hariyadi
http://creativecommons.org/licenses/by-nc/4.0
oai:jurnal.ugm.ac.id:article/32479
2019-11-27T00:49:27Z
bik:ART
Longevity and development of Aedes aegypti larvae to imago in domestic sewage water
Martini, M
Triasputri, Yuniar
Hestiningsih, Retno
Yuliawati, Sri
Purwantisasi, Susiana
Ae. aegypti; larvae; breeding places; DHF; EBP
Dengue Hemorrhagic Fever (DHF) caused by dengue virus transmitted by Aedes aegypti (Ae. Aegypti) that lives and breeds in clean water. The aim of the study was to analyze the difference of the longevity and development of Ae. aegypti larva in the difference pH of domestic sewage water. This experimental used post only control group design to analyze population of Ae. aegypti instar III larvae which was bred in the Entomology Laboratory of the Faculty of Public Health, Diponegoro University, Semarang, Central Java. The number of tested larvae was 25 per media with six replications. Thus, the total number of larvae was 750. Data were analyzed using Kruskal Wallis and followed by Mann Whitney test. The result showed that Ae. aegypti larva could survive and breed to be mosquitos in the domestic sewage water with various pH levels. There was significant difference between the number of larvae transforming to pupa (p=0.002), pupa to imago (p=0.001), and the number of survival imago until second week (p<0.001) in the domestic waste water with various pH levels. Other findings revealed that people tended to wash away larvae they found in the water, but still used the water for daily live. As a result, the larvae bred in the domestic sewage water. Therefore, elimination breeding place (EBP) program needs to be socialized to make people aware of either domestic waste water or domestic clean water.
Universitas Gadjah Mada
2019-09-17
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://jurnal.ugm.ac.id/bik/article/view/32479
10.19106/JMedSci005104201906
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 325-332
Journal of the Medical Sciences (Berkala Ilmu Kedokteran); Vol 51, No 4 (2019); 325-332
2356-3931
eng
https://jurnal.ugm.ac.id/bik/article/view/32479/pdf
Copyright (c) 2019 M Martini, Yuniar Triasputri, Retno Hestiningsih, Sri Yuliawati, Susiana Purwantisasi
http://creativecommons.org/licenses/by-nc/4.0
e7d87d82b6fb54f1b7af449f99a133e4