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Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the Potential as Noodle for Type 2 Diabetes Mellitus Treatment


 
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1. Title Title of document Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the Potential as Noodle for Type 2 Diabetes Mellitus Treatment
 
2. Creator Author's name, affiliation, country Fitriyani Fitriyani; Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia
 
2. Creator Author's name, affiliation, country Salsabila E.S. Ningrum; Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia
 
2. Creator Author's name, affiliation, country Rohiatul Mutiah; Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia
 
2. Creator Author's name, affiliation, country Larasati Sekar Kinasih; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Chypotes Noodle; Hydroxycinnamic Acids; Network Pharmacology; Tamarillo; Type 2 DM
 
4. Description Abstract

Consuming noodles excessively is not good for health because it contains high trans fat, which can cause diabetes mellitus (DM) as a disease with a high prevalence, especially type 2 DM, as much as 95% in Indonesia. Tamarillo (Chypomandra betacea Cav.) can potentially reduce blood glucose levels and restore adipokine regulation to prevent insulin resistance in type 2 DM. This study aims to determine the formulation and potential of tamarillo compounds into noodle products named "Chypotes (Chypomandra Antidiabetes) Noodle" as an alternative food for type 2 DM patients.  The methods used are noodle formulation, organoleptic test, hedonic test, and network pharmacology.  Based on the results of an organoleptic test, Chypotes Noodle has a chewy texture, a distinctive smell, yellow colour, and a slightly sour tasteless taste typical of Tamarillo. Based on the results of the hedonic test, 30 respondents chose the like and very like options in filling out the questionnaire with a percentage of 80-90%. Based on the Network Pharmacology of Tamarillo shows that 150 of the 365 target proteins of Tamarillo are involved in the biological processes and signaling pathways of type 2 diabetes mellitus, with 75 target proteins locking and interacting. Compound Molecules of Tamarillo, such as six bioactive components of the hydroxycinnamic acids group, have activity in type 2 DM and affect the biological processes and signaling pathways of type 2 DM against ADIPOQ, TNF, and INS. Therefore, Tamarillo can potentially be used as an alternative food product in the form of noodles for type 2 DM treatment.

 
5. Publisher Organizing agency, location Faculty of Pharmacy, Universitas Gadjah Mada
 
6. Contributor Sponsor(s) Prof. Apt. Roihatul Mutiah, S.Farm., M.Kes.
 
7. Date (YYYY-MM-DD) 2023-11-30
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://jurnal.ugm.ac.id/TradMedJ/article/view/84655
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.22146/mot.84655
 
11. Source Title; vol., no. (year) Majalah Obat Tradisional; Vol 28, No 3 (2023)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2023 Majalah Obat Tradisional
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