Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the Potential as Noodle for Type 2 Diabetes Mellitus Treatment
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1. | Title | Title of document | Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the Potential as Noodle for Type 2 Diabetes Mellitus Treatment |
2. | Creator | Author's name, affiliation, country | Fitriyani Fitriyani; Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia |
2. | Creator | Author's name, affiliation, country | Salsabila E.S. Ningrum; Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia |
2. | Creator | Author's name, affiliation, country | Rohiatul Mutiah; Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia |
2. | Creator | Author's name, affiliation, country | Larasati Sekar Kinasih; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim Islamic State University of Malang, East Java; Indonesia |
3. | Subject | Discipline(s) | |
3. | Subject | Keyword(s) | Chypotes Noodle; Hydroxycinnamic Acids; Network Pharmacology; Tamarillo; Type 2 DM |
4. | Description | Abstract | Consuming noodles excessively is not good for health because it contains high trans fat, which can cause diabetes mellitus (DM) as a disease with a high prevalence, especially type 2 DM, as much as 95% in Indonesia. Tamarillo (Chypomandra betacea Cav.) can potentially reduce blood glucose levels and restore adipokine regulation to prevent insulin resistance in type 2 DM. This study aims to determine the formulation and potential of tamarillo compounds into noodle products named "Chypotes (Chypomandra Antidiabetes) Noodle" as an alternative food for type 2 DM patients. The methods used are noodle formulation, organoleptic test, hedonic test, and network pharmacology. Based on the results of an organoleptic test, Chypotes Noodle has a chewy texture, a distinctive smell, yellow colour, and a slightly sour tasteless taste typical of Tamarillo. Based on the results of the hedonic test, 30 respondents chose the like and very like options in filling out the questionnaire with a percentage of 80-90%. Based on the Network Pharmacology of Tamarillo shows that 150 of the 365 target proteins of Tamarillo are involved in the biological processes and signaling pathways of type 2 diabetes mellitus, with 75 target proteins locking and interacting. Compound Molecules of Tamarillo, such as six bioactive components of the hydroxycinnamic acids group, have activity in type 2 DM and affect the biological processes and signaling pathways of type 2 DM against ADIPOQ, TNF, and INS. Therefore, Tamarillo can potentially be used as an alternative food product in the form of noodles for type 2 DM treatment. |
5. | Publisher | Organizing agency, location | Faculty of Pharmacy, Universitas Gadjah Mada |
6. | Contributor | Sponsor(s) | Prof. Apt. Roihatul Mutiah, S.Farm., M.Kes. |
7. | Date | (YYYY-MM-DD) | 2023-11-30 |
8. | Type | Status & genre | Peer-reviewed Article |
8. | Type | Type | |
9. | Format | File format | |
10. | Identifier | Uniform Resource Identifier | https://jurnal.ugm.ac.id/TradMedJ/article/view/84655 |
10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.22146/mot.84655 |
11. | Source | Title; vol., no. (year) | Majalah Obat Tradisional; Vol 28, No 3 (2023) |
12. | Language | English=en | en |
13. | Relation | Supp. Files | |
14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
15. | Rights | Copyright and permissions |
Copyright (c) 2023 Majalah Obat Tradisional![]() This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |