2,6-Dichloro-4-nitroaniline –loaded Electrospun Cellulose Acetate Fiber Mats and Their Release Characteristics

https://doi.org/10.22146/ajche.50088

Patcharaporn Thitiwongsawet(1*), Paweena Ouykul(2), Akkarin Khaoroppan(3)

(1) Department of Chemical Engineering, Faculty of Engineering, Thammasat University, Klong-Luang, Pathumthani, 12120, Thailand
(2) Department of Materials Science and Technology, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand
(3) Department of Materials Science and Technology, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand
(*) Corresponding Author

Abstract


Mats of cellulose acetate (CA) nanofibers containing 2,6-dichloro-4-nitroaniline (DCNA) were successfully fabricated by electrospinning from the neat CA solution (17% w/v in 2:1 acetone/dimethylacetamide) containing DCNA in various amounts (i.e. 5-15 wt. % based on the weight of CA). The morphological appearance of both the neat and the DCNA-loaded electrospun CA fibers were smooth and the incorporation of DCNA in the neat CA solution did not affect the morphology of the resulting fibers. The average diameters of the neat and the DCNA-loaded electrospun CA fibers ranged between 241-320 nm. The integrity of the as-loaded DCNA in the DCNA-loaded CA fiber mats was intact as verified by the 1H-nuclear magnetic resonance spectroscopic method. The amount of water retention, the amount of weight loss, and release characteristics of the DCNA-loaded CA fiber mats and the DCNA-loaded as-cast films in distilled water at 30°C were studied. The release characteristics were investigated by the total immersion method. The DCNA-loaded CA fiber mats exhibited greater amount of water retention, weight loss, and DCNA released than the DCNA-loaded as-cast films.

Keywords


Drug delivery, Electrospinning, Cellulose Acetate, 2,6-Dichloro-4-nitroaniline

Full Text:

PDF


References

  1. Beckman, K.M., and Parsons, J.E. (1965). Fungicidal control of sclerotinia wilt in green beans, Plant Dis. Rep., 49. 357.
  2. Bottcher, H., Jagota, C., Trepte, J., Kallies, K.H., and Haufe, H. (1999). Sol–gel composite films with controlled release of biocides, J. Control. Release, 60. 57.
  3. Deitzel, J.M., Kleinmeyer, J., Harris, D., and Beck Tan, N.C. (2001). The effect of processing variables on the morphology of electrospun nanofibers and textiles, Polymer, 42. 261.
  4. Doshi, J., and Reneker, D.H. (1995). Electrospinning process and applications of electrospun fibers, J. Electrost., 35. 151.
  5. Kenawy, E.R., Bowlin, G.L., Mansfield, K., Layman, J., Simpson, D.G., Sanders, E.H., and Wnek, G.E. (2002). New Drug Delivery System: Control Release of Tetracycline Hydrochloride as a Model Drug from Electrospun Fibers of Poly(lactic acid) and Poly(ethylene vinyl acetate), J. Control. Release, 81(1-2). 57.
  6. Liu, H., and Hsieh, Y.L. (2002). Ultrafine fibrous cellulose membranes from electrospinning of cellulose acetate, J. Polym. Sci.-Polymer Physics, 40. 2119.
  7. Rujiravanit, R., Kruaykitanon, S., Jamieson, A.M., and Tokura, S. (2003). Preparation of crosslinked chitosan/silk fibroin blend films for drug delivery system, Macromol. Biosci., 3. 604.
  8. Singh, B., Sharma, D.K., and Gupta, A. (2008). In vitro release dynamics of thiram fungicide from starch and poly(methacrylic acid)-based hydrogels, J. Hazard. Mater., 154. 278.
  9. Suwantong, O., Opanasopit, P., Ruktanonchai, U., and Supaphol, P. (2007). Electrospun Cellulose Acetate Fiber Mats Containing Curcumin and Release Characteristic of the Herbal Substance, Polymer, 48. 7546.
  10. Taepaiboon, P., Rungsardthong, U., and Supaphol, P. (2006). Drug-Loaded Electrospun Mats of Poly(vinyl alcohol) Fibres and Their Release Characteristics of Four Model Drugs, Nanotechnology, 17. 2317.
  11. Taepaiboon, P., Rungsardthong, U., and Supaphol, P. (2007). Vitamin-Loaded Electrospun Cellulose Acetate Nanofiber Mats as Transdermal and Dermal Therapeutic Agents for Vitamin A Acid and Vitamin E, Eur. J. Pharm. Biopharm., 67. 387.
  12. Tungprapa, S., Jangchud, I., and Supaphol, P. (2007). Release Characteristics of Four Model Drugs from Drug-Loaded Electrospun Cellulose Acetate Fiber Mats, Polymer, 48. 5030.
  13. Wells, J.M. (1972). Heated wax-emulsions with benomyl and 2,6-dichloro-4-nitroaniline for control of postharvest decay of peaches and nectarines, Phytopathology, 62. 129.
  14. Zeng, J., Aigner, A., Czubayko, F., Kissel, T., Wendorff, J.H., and Greiner, A. (2005). Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings, Biomacromolecules, 6. 1484.



DOI: https://doi.org/10.22146/ajche.50088

Article Metrics

Abstract views : 1419 | views : 1066

Refbacks

  • There are currently no refbacks.


ASEAN Journal of Chemical Engineering  (print ISSN 1655-4418; online ISSN 2655-5409) is published by Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada.